Effect of extraction vehicles on medical device sensitization testing by LuSens assay [0.03%]
提取介质对LuSens医疗设备致敏性测试的影响
L Svobodova,E Pacalova,K Kejlova et al.
L Svobodova et al.
Skin sensitization risk of medical devices (MDs) has to be assessed before their marketing and clinical use. The obligatory methods (ISO 10993-10:2021) include exclusively in vivo tests, however, validated non-animal methods might be utiliz...
Corrigendum to "The pesticide fungicide difenoconazole modulates the biophysical properties of sodium channel Nav1.5" [Toxicology in vitro, 2025, 106152] [0.03%]
关于“杀菌剂difenoconazole调节钠通道Nav1.5的生物物理特性”[In Vitro毒理学，2025，106152]的勘误表
V Fogaça-Santos,F S Alcântara,M R L Conceição et al.
V Fogaça-Santos et al.
Neuromodulatory efficacy of Bacopa monniera extract against streptozotocin-induced neuronal dysfunction in SH-SY5Y cells: Implications for diabetic neuropathy [0.03%]
Bacopa monniera提取物调节神经干细胞分化改善糖尿病神经病变的电生理功能障碍：对神经元的作用机制研究
H S Bhumika,M D Pandareesh
H S Bhumika
Diabetic neuropathy (DN), a major complication of diabetes mellitus, is characterized by progressive neuronal damage driven by hyperglycemia-induced oxidative stress, mitochondrial dysfunction, and advanced glycation end product (AGE) accum...
Thymoquinone attenuates poly(I:C)-induced cellular stress via PKR/ATF4/CHOP signaling and autophagy modulation in human alveolar epithelial cells [0.03%]
鼠李素通过PKR/ATF4/CHOP信号通路和自噬调节缓解聚肌苷酸C诱导的人肺泡上皮细胞的内质网应激
Umut Kerem Kolac,Bakiye Goker Bagca,Gizem Donmez Yalcin et al.
Umut Kerem Kolac et al.
Alveolar type II (ATII) epithelial cells are essential for maintaining pulmonary homeostasis and defending against viral pathogens. Polyinosinic:polycytidylic acid [Poly(I:C)], a synthetic analog of viral double-stranded RNA, activates prot...
Liposomal nanoparticles containing adenosine triphosphate targeted by heart-specific peptide ligands as antidotes for aluminum phosphide poisoning in isolated rat cardiomyocyte cell line [0.03%]
心肌细胞系中特异性富集ATP的载药脂质体用于治疗磷化铝中毒的研究
Roghayeh Jahani,Hamidreza Mohammadi,Mohammad Seyedabadi et al.
Roghayeh Jahani et al.
Aluminum phosphide (ALP) poisoning remains a critical challenge because of the limited number of treatment options. ALP disrupts the electron transport chain, causing ATP depletion, oxidative stress, and cytotoxicity. This study developed i...
Metabolic stability and effects of microsomal enzymes on the activity of the sonic hedgehog pathway inhibitor piperonyl butoxide [0.03%]
pipernyl但氧对声波刺猬信号通路抑制作用及代谢稳定性与微粒体酶的作用研究
Kenneth S Rivera-González,Cameron O Scarlett,Robert J Lipinski
Kenneth S Rivera-González
The pesticide synergist piperonyl butoxide (PBO) is a methylenedioxy compound used in many pesticide formulations. Previous studies identified PBO as an inhibitor of the Sonic hedgehog (Shh) signaling pathway and linked prenatal PBO exposur...
Effects of heated tobacco products and conventional cigarettes on oxidative stress and inflammation in alveolar macrophages [0.03%]
加热烟草产品和常规卷烟对肺泡巨噬细胞氧化应激和炎症的影响
Ok Joo Sul,Hye Won Choi,Seo Hee Park et al.
Ok Joo Sul et al.
Oxidative stress in macrophages is a major factor contributing to smoking-induced chronic respiratory diseases. However, the oxidative stress induced by heat-not-burn tobacco products (HTP) and conventional cigarettes (3R4F) in macrophages ...
Tributyltin propionate and tributyltin salicylate represent novel RXR ligands: Effects on transcriptional activity of thyroid hormone receptor and vitamin D3 receptor [0.03%]
三正丁基锡丙酸酯和三正丁基锡水杨酸盐是新颖的RXR配体：对甲状腺激素受体和维生素D3受体转录活性的影响
Dana Macejova,Jakub Kollar,Zdenek Dvorak et al.
Dana Macejova et al.
Several organometallic trialkyltins or triaryltins are known to act as retinoid X receptor (RXR) agonists, which were also reported to exert eminent cytotoxic properties. In the present study, binding properties of tributyltin propionate (T...
First toxicity profile of aminoindane-based new psychoactive substances: 2-aminoindane (2-AI, CAS: 2975-41-9) and N-Methyl-2-aminoindane (NM-2-AI, CAS: 24445-44-1) - comprehensive prediction of toxicological endpoints important from clinical and forensic perspective using in silico multi- approach [0.03%]
首个人工合成大麻素类精神活性物质2-氨基茚（2-AI）及其甲基衍生物N-甲基-2-氨基茚（NM-2AI）的毒性谱分析：从临床及法医毒理学角度预测其重要毒性终点的多学科计算毒理学研究
Kamil Jurowski,Adrian Frydrych
Kamil Jurowski
This study provides the first toxicity profile of two aminoindane-based new psychoactive substances (NPS): 2-aminoindane (2-AI) and N-methyl-2-aminoindane (NM-2-AI), using a multi-method in silico approach. Tools including Percepta, ProTox ...
The pesticide fungicide difenoconazole modulates the biophysical properties of sodium channel Nav1.5 [0.03%]
杀菌剂difenoconazole调节钠通道Nav1.5的生物物理性质
V Fogaça-Santos,F S Alcântara,Conceição Mrl et al.
V Fogaça-Santos et al.
Difenoconazole (DIF) is a widely used fungicide in agriculture, but it is unknown if it can modulate the excitability of the heart tissue. Thus, we investigated the acute effect of DIF on the electrical properties of heart tissue, with a pa...