Diesel exhaust nanoparticles: Cellular adaptation in lung epithelial and fibroblast cells - An in vitro study [0.03%]
柴油尾气纳米颗粒对人体肺上皮细胞和纤维母细胞的体外研究
Gabriel Martínez-Razo,Ruth Angélica Lezama,Armando Vega-López et al.
Gabriel Martínez-Razo et al.
Diesel exhaust particles (DEnP) represent a major urban air pollutant with known adverse effects on human health, yet detailed cellular interactions at the nanoscale are poorly understood. This study aims to elucidate the cellular responses...
Barriergel formulations and coated gloves to reduce skin permeation of nicotine and protect against green tobacco sickness [0.03%]
屏障凝胶配方和涂布手套可减少尼古丁的皮肤渗透并预防烟草病
Abhay U Andar,Youcheng Liu,Dana C Hammell et al.
Abhay U Andar et al.
Tobacco harvesting workers may have high levels of skin exposure to nicotine that can lead to green tobacco sickness. Current exposure reduction methods are often infeasible. The purpose of this work was to develop and evaluate the effectiv...
Interactions of neocryptotanshinone and human cytochrome P450 in silico and in vitro [0.03%]
基于新型丹参茋类成分新隐丹参素与人肝微粒体CYP450的药物相互作用研究
Xiu Chen,Xiaoyi Pan,Jieping Zhao et al.
Xiu Chen et al.
Neocryptotanshinone (NCTS), an ingredient of Salviae Miltiorrhizae Radix et Rhizoma, is a promising compound for development since it exhibits various pharmacological effects including hypoglycemic and anti-inflammatory activities. In this ...
Activation of Toll-like receptor 2 reveals microbial contamination beyond endotoxins on micro- and nanoplastics [0.03%]
激活Toll样受体2揭示了微塑料和纳米塑料上内毒素以外的微生物污染
Øyvind P Haugen,Itziar Polanco-Garriz,Victor Alcolea-Rodriguez et al.
Øyvind P Haugen et al.
Current literature on health hazards associated with micro- and nanoplastics (MNPs) is largely influenced by studies that insufficiently account for potential microbial contamination of their test materials. This may lead to misinterpretati...
Cisplatin adducts at DNA or RNA do not affect their cellular isolation efficiencies using column-based kits or manual Trizol-based purification methods [0.03%]
顺铂DNA或RNA加合物不会影响其使用基于柱的试剂盒或手动Trizol基纯化方法的细胞分离效率
Ketaki Sandu,Dirk Theile
Ketaki Sandu
In experimental toxicology, evaluating cisplatin adducts at DNA or RNA is often required but can be complicated by methodological aspects. For instance, the cross-linking might affect the nucleic acid isolation efficiencies, which in turn c...
Optimisation of ultrafine particle exposure in an alveolar tri-culture model at the air-liquid interface [0.03%]
基于空气液体界面的肺泡立体三维模型中超细颗粒物暴露的优化研究
Anna-Katharina Hensel,Henri Hakkarainen,Mo Yang et al.
Anna-Katharina Hensel et al.
Air-liquid interface (ALI) systems have emerged as a physiologically relevant in vitro platform for evaluating the toxicological impact and potential health effects of airborne pollutants. When utilizing collected ultrafine particles (UFPs)...
Alternatives to animal testing in cosmetic products: A patent applications review and future perspectives [0.03%]
化妆品动物试验替代方法的专利申请回顾及未来展望
Carine Cassimiro Cedrola,Clara Cassimiro Cedrola,Ana Cláudia Chagas de Paula et al.
Carine Cassimiro Cedrola et al.
Ethical concerns, high costs, and scientific limitations associated with animal testing have accelerated the search for alternative methods to evaluate the safety and efficacy of topical cosmetic formulations. This study provides a comprehe...
Corrigendum to 'Particulate matter exposure-induced holesterol metabolism dysregulation in lung epithelial cells' [Toxicology in Vitro 111 (2026) 106164] [0.03%]
关于“颗粒物暴露引起的肺上皮细胞胆固醇代谢紊乱”的勘误(《体内毒理学》第111卷(2026)页106164)
Huanxiang Li,Yimin Li,Xiaozhen Wang
Huanxiang Li
Quercetin mitigates pro-inflammatory effects of polyvinylpyrrolidone-coated silver nanoparticles on human intestinal epithelial cells [0.03%]
檞皮素可减轻聚乙烯吡咯烷酮包覆的银纳米粒子对人肠上皮细胞促炎症的影响
Adelaide Sousa,Inês Santos,Rui Fernandes et al.
Adelaide Sousa et al.
Extended oral intake of silver nanoparticles (AgNP) may result in significant exposure of intestinal cells, which could trigger intestinal inflammation, an effect that requires deep comprehension and the development of mitigation measures. ...
Quantitative in vitro to in vivo extrapolation (QIVIVE) of atrazine's effects on phosphodiesterase and aromatase mRNA expression in vitro to the rat in vivo based on pharmacokinetic [0.03%]
基于药代动力学的阿特拉津在体外和体内对磷酸二酯酶和芳香化酶mRNA表达的影响的定量外推（QIVIVE）
James W Simpkins,Ralph L Cooper,Charles Breckenridge
James W Simpkins
This study investigated the effects of atrazine (ATZ) and its metabolites on phosphodiesterase (PDE) activity ex vivo and aromatase mRNA expression in two steroidogenic cell lines (H295R and JEG-3). The pharmacokinetics of ATZ and its chlor...