Quantitative in vitro to in vivo extrapolation (QIVIVE) of atrazine's effects on phosphodiesterase and aromatase mRNA expression in vitro to the rat in vivo based on pharmacokinetic
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This study investigated the effects of atrazine (ATZ) and its metabolites on phosphodiesterase (PDE) activity ex vivo and aromatase mRNA expression in two steroidogenic cell lines (H295R and JEG-3). The pharmacokinetics of ATZ and its chlorometabolites were ch... ...
