Corrigendum to "Tetrazolium-based colorimetric assays underestimat the direct antitumor effects of bevacizumab" [Toxicology in vitro 91 (2023) 105631] [0.03%]
关于“四唑比色测定法低估了贝伐单抗的直接抗肿瘤作用”的勘误说明（载于《体外毒理学》第91卷（2023年）105631页）
Pei Wei,Min Wang,Mao Lin et al.
Pei Wei et al.
Integrative toxicity assessment of tocotrienol-rich fraction from palm oil using in silico methods and zebrafish embryotoxicity model [0.03%]
基于掌油托可汀醇富集组分的整合毒性评估：结合计算机模拟和斑马鱼胚胎模型的方法
Thenmoly Damodaran,Najib Sani Yahaya,Mohd Nizam Mordi
Thenmoly Damodaran
Tocotrienol-rich fraction (TRF), a natural form of vitamin E derived from palm oil, possesses antioxidant properties. However, its potential embryonic developmental toxicity remains unclear. This study investigated TRF's toxicity using in s...
Ozone and particulate matter co-exposure at the air-liquid interface: Establishing an approach to assess pollutant interactions in vitro [0.03%]
臭氧和颗粒物联合暴露的空气液体界面模型：建立一种体外评估污染物相互作用的方法
Andres Henriquez,Marjolaine Godbout-Cheliak,Alain Filiatreault et al.
Andres Henriquez et al.
Background: Air pollution is a complex mixture of gases and particulates that varies spatially and temporally, making attribution of adverse effects to specific individual air pollutants a challenge. To disentangle effect...
The effect of organic solvents on the in vitro transport activity of three OATP isoforms [0.03%]
有机溶剂对三种OATP亚型的体外转运活性的影响
Rina Saito,Takeshi Akiyoshi,Kazunari Tsujii et al.
Rina Saito et al.
Purpose: In vitro studies of transporter activity often require the addition of organic solvents such as dimethyl sulfoxide (DMSO), methanol, and ethanol, to dissolve substrates and/or inhibitors. Although this may attenu...
The cyanobacterial toxins BMAA and 2,4-DAB perturb the l-serine biosynthesis pathway and induce systemic changes in energy metabolism in human neuroblastoma cells: A proteomic study [0.03%]
蓝藻毒素BMAA和2,4-DAB扰动L-丝氨酸生物合成途径并引起人神经母细胞瘤细胞能量代谢的系统变化：蛋白质组学研究
Lisa Pu,Joel R Steele,Connor R Phillips et al.
Lisa Pu et al.
Blue-green algae (cyanobacteria), an ancient phylum of bacteria, produce a wide array of secondary metabolites that are toxic to humans. Rapid growth of cyanobacteria in an aquatic environment can result in algal blooms capable of turning w...
Inhibition of JAK2/STAT3 by pacritinib synergizes with chemotherapy in esophageal carcinoma [0.03%]
JAK2/STAT3的抑制剂pacritinib与化疗药物联用在食管癌治疗中具有协同作用
Lan Han,Yinyin Sun,Kai Yang et al.
Lan Han et al.
The poor outcomes associated with esophageal carcinoma, particularly in advanced stages, necessitate the development of new treatment strategies. This study examines the efficacy of pacritinib, a multi-kinase inhibitor, both alone and in co...
Effects of 17β-estradiol and estrogen receptor subtype-specific agonists on Jurkat E6.1 T-cell leukemia cells [0.03%]
雌二醇和雌激素受体亚型特异性激动剂对Jurkat E6.1 T细胞白血病细胞的影响
Rahul S Nair,Mantavya N Patel,Thangamani Kannan et al.
Rahul S Nair et al.
Background: Estrogen signaling plays a crucial role in immune regulation and cancer metabolism, yet its impact on T-cell leukemia remains unclear. In hematological malignancies, estrogen receptor (ER) activation may influ...
Development of skin corrosion and irritation test methods employing ex vivo porcine skin model [0.03%]
利用体外猪皮模型开发皮肤腐蚀和刺激试验方法的发展
Jeong-Hyun Hong,Kyung-Min Lim
Jeong-Hyun Hong
Skin corrosion and irritation are key local toxicological responses of the skin to chemical exposure. Conventional in vivo methods have limitations such as species difference, ethical concern, and reproducibility issue, necessitating the de...
Prolonged exposure to simvastatin affects coenzyme Q9/10 status leading to impaired mitochondrial respiratory capacity and reduced viability of cultured cardiac cells [0.03%]
辛伐他汀的长期暴露影响辅酶Q9/10的状态，导致培养的心脏细胞线粒体呼吸能力和存活率降低
Sinenhlanhla X H Mthembu,Sithandiwe E Mazibuko-Mbeje,Sonia Silvestri et al.
Sinenhlanhla X H Mthembu et al.
This study investigates the effects of prolonged simvastatin exposure on coenzyme Q9/10 (CoQ9/10) levels, an essential component of antioxidant defense, in cultured cardiac cells. Statins, commonly used to manage dyslipidemia and reduce car...
Effect of serotonin 7 receptors and transcript variants on RIN-5F pancreatic beta cell line [0.03%]
血清素7受体及其转录异构体对RIN-5F胰岛β细胞系的影响
Muhammed Yayla,Erdem Toktay,Bengul Özdemir et al.
Muhammed Yayla et al.
Purpose: The physiological effects of 5-HT7 receptors expressed in pancreatic beta cells have not yet been elucidated. We first aimed to investigate the effect of 5-HT7 receptor agonist (AS19) and antagonist (SB269970) ap...