The neuroprotective role of chlorogenic acid and Fisetin in differentiated neuronal cell line-SHSY5Y against amyloid-β-induced neurotoxicity [0.03%]
氯ogenic酸和Fisetin通过抑制Tau过度磷酸化对抗Aβ诱导神经毒性的作用及其机制研究
Apoorv Sharma,Puneet Kumar,Asimul Islam et al.
Apoorv Sharma et al.
Alzheimer's disease (AD) is a neurodegenerative disorder and characterized by amyloid-beta (Aβ) accumulation, synaptic dysfunction, oxidative stress, and lacks effective therapies. Fisetin and chlorogenic acid (CGA) are natural polyphenols...
Beyond traditional toxicology: The transformative power of PBTK modeling [0.03%]
超越传统毒理学：PBTK建模的变革力量
Anagha Damre,Aniruddha Banerjee
Anagha Damre
Physiologically Based Toxicokinetic (PBTK) modeling has emerged as a crucial tool in toxicokinetics, enabling the quantitative assessment of chemical absorption, distribution, metabolism, and excretion (ADME) across various biological syste...
Inter-laboratory validation study of an in vitro glucocorticoid receptor transactivation assay for testing potential endocrine disrupting chemicals [0.03%]
体外糖皮质激素受体转录激活分析的实验室间验证研究以测试潜在的内分泌干扰素
Andrea Rivero-Arze,Marina Grimaldi,Géraldine Maillet et al.
Andrea Rivero-Arze et al.
The glucocorticoid receptor (GR) belongs to the family of steroid receptors (SRs). These receptors regulate a vast selection of cell-, tissue-, and organism biology, and are also targets of endocrine disrupting chemicals warranting design a...
Lupeol-loaded PLGA particles conserve anti-topoisomerase activity and decrease the cytotoxicity of lupeol [0.03%]
卢泊醇载药PLGA微球使卢泊醇保持拓扑异构酶活性并降低其细胞毒性
Francisco Fabián Razura-Carmona,Mayra Herrera-Martínez,Jorge Alberto Sánchez-Burgos et al.
Francisco Fabián Razura-Carmona et al.
Lupeol (LP), a bioactive triterpene, has been extensively studied for its chemoprotective, anti-inflammatory, and anti-arthritic properties. To enhance its bioavailability, lupeol-loaded polylactic-co-glycolic acid (PLGA) nanoparticles, des...
Testing chemicals for CYP19 inhibition: Comparison of a modified H295R steroidogenesis assay to a commercial fluorometric enzyme inhibition kit [0.03%]
CYP19抑制剂的化学药物检测：改良型H295R固醇合成检测与商用荧光酶联抑制检测试剂盒的比较
Caroline Despicht,Kieu-Mi Tran,Terje Svingen et al.
Caroline Despicht et al.
Aromatase (CYP19A1) is a key enzyme that converts androgens to estrogens. Given its central role in estrogen biosynthesis, aromatase is a target of endocrine disruption. Aromatase disruption can be measured in vitro with cell-free enzyme as...
Impact of gadolinium oxide based nanoparticles on genotoxic, cytotoxic and oxidative stress in human lymphocytes [0.03%]
纳米氧化钆对人淋巴细胞的遗传毒性和细胞毒性的影响
Isela Álvarez-González,Lizbeth Espinosa-García,Felipe de Jesús Carrillo-Romo et al.
Isela Álvarez-González et al.
Gadolinium-based nanoparticles are presently applied in biomedicine and industry, and their potential is increasing. In this report we synthetized three nanoparticles by the sol-gel, supercritical drying method: Gd2O3, Gd2O3 doped with Eu+3...
E171-induced toxicity in human iPSC-derived colon organoids: Effects on cell viability, ROS generation, DNA damage, and gene expression changes [0.03%]
E171诱导的类器官毒性：对人iPSC来源结肠类器官细胞活力，ROS生成，DNA损伤及基因表达变化的影响
Nicolaj S Bischoff,Anna K Undas,Marcel van Herwijnen et al.
Nicolaj S Bischoff et al.
Food-grade titanium dioxide (E171) is a widely used food additive with debated safety, particularly regarding its genotoxic effects. This study assessed the dose-dependent toxicity of E171 in human induced pluripotent stem cell (iPSC)-deriv...
The protective mechanisms of glycyrrhizic acid for deoxynivalenol-induced toxicity in rabbit corneal stroma [0.03%]
甘草酸对DON致兔角膜基质毒性的保护机制研究
Chunlan Liang,Xuewei Xiong,Qi Shi et al.
Chunlan Liang et al.
Objectives: This study aimed to investigate the effects and mechanisms of deoxynivalenol (DON) on rabbit corneal stroma cell culture and observe the protective effect of glycyrrhizic acid (GA) against DON-induced damage. ...
Corrigendum to "Assessing the safety of midazolam: A comprehensive analysis of adverse events from FAERS" [Toxicology in vitro 105 (2025) 106023] [0.03%]
关于“评估咪达唑仑的安全性：来自FAERS的不良事件全面分析”的勘误修正（In Vitro Toxicology 105(2025)106023)）
Jieyuan Chen,Zhaojun Wang,Li Wei et al.
Jieyuan Chen et al.
Dodecyldimethylamine oxide may induce lysosomal-associated cell death: Potential lipotoxicity [0.03%]
十二烷基二甲基氨基氧化物可能诱导溶酶体相关细胞死亡：潜在的脂毒性
Eun-Jung Park,Minseok Seo,Wonkyun Jung et al.
Eun-Jung Park et al.
Dodecyldimethylamine oxide (DDAO) is one of the most commonly used chemicals in household products, including spray types. We identified the potential toxicity mechanism using human bronchial epithelial cells. After 6 h of exposure, DDAO de...