Bacosine triggers NRF2-TFEB-autophagy axis to attenuate arecoline-induced oxidative stress and inflammasome activation [0.03%]
巴可辛通过激活NRF2-TFEB-自噬轴减轻Areca素诱导的氧化应激和炎性小体活化
Priyadarshini Mishra,Rakesh Kumar Kar,Soumya Ranjan Mishra et al.
Priyadarshini Mishra et al.
Arecoline, the principal constituent of areca nut, triggers oxidative stress and inflammasome activation, leading to chronic inflammation and oral cancer development. The aim of this study was to investigate the antioxidant and anti-inflamm...
Cellular responses to morpholinated curcumin derivatives in human muscle-invasive bladder cancer cells [0.03%]
一类新型茋类衍生物对人类肌肉浸润性膀胱癌细胞的细胞作用研究
Paulina Kobylka,Marek Murias,Pawel Bakun et al.
Paulina Kobylka et al.
Curcumin is a well-known compound with anticancer properties, as demonstrated in preclinical studies. However, its clinical potential is limited by several drawbacks. Medicinal chemistry, therefore, offers the opportunity to develop curcumi...
Cellular toxicity assessment of common plasticizers: Implications for musculoskeletal and cardiovascular health [0.03%]
常见增塑剂的细胞毒性评估：对肌肉骨骼和心血管健康的影响
Cassandra Bradley,Ramon Lavado
Cassandra Bradley
The cardiovascular toxicity of plasticizers remains insufficiently characterized, despite increasing evidence linking environmental chemical exposures to vascular dysfunction and cardiometabolic disease. Regulatory restrictions on legacy pl...
Orthogonal viability assays and high-content phenotyping identify enhanced cytotoxicity of SLN-pDNA complexes and heightened sensitivity in PC-3 cells [0.03%]
正交活力测定和高内涵表型分析识别出SLN-pDNA复合物的增强细胞毒性以及PC-3细胞中较高的敏感性
Thaís Moraes-Lacerda,Fernanda Garcia-Fossa,Marcelo Bispo de Jesus et al.
Thaís Moraes-Lacerda et al.
Solid lipid nanoparticles (SLNs) have emerged as a versatile platform for the intracellular delivery of therapeutic molecules being widely used in drug and gene delivery owing to their biocompatibility, scalability, and long-term stability....
Ultrafine particles induce ferroptosis-like stress features in human dopaminergic LUHMES cells via the p53/xCT/GSH/cGPx4 axis [0.03%]
超细颗粒物通过p53/xCT/GSH/cGPX4轴诱导人类多巴胺能LUHMES细胞出现铁死亡样应激特征
Emma Theerens,Aurélie Jonneaux,Lydia Nikasinovic et al.
Emma Theerens et al.
Parkinson's disease (PD) involves progressive loss of dopaminergic neurons in the Substantia Nigra pars compacta, with regulated cell death (RCD) pathways - ferroptosis and apoptosis - contributing to neurodegeneration. Ferroptosis, an iron...
Context-dependent effects of high-frequency pulsed electromagnetic fields on cytokine responses in human THP-1 monocytes in vitro [0.03%]
高频脉冲电磁场对体外培养的人THP-1单核细胞细胞因子反应的调节作用及机制研究
Samir Dekali,Nicolas Jolly,Suzanne De Araujo et al.
Samir Dekali et al.
High-frequency pulsed electromagnetic fields (HF-EMF) are increasingly encountered in modern environments, yet their potential immunomodulatory effects remain unclear. Here, we investigated whether L-band pulsed HF-EMF modulate cytokine res...
18-β-Glycyrrhetinic-loaded poly(lactic-co-glycolic) (PLGA) nanoparticles downregulate the expression LPS-induced proteins mediating tissue remodelling in vitro [0.03%]
甘草酸载药聚乳酸-羟基乙酸纳米粒下调LPS诱导的介导组织重塑蛋白质的表达
Gabriele De Rubis,Vyoma K Patel,Dinesh Kumar Chellappan et al.
Gabriele De Rubis et al.
Inflammation is a central pathophysiological feature of numerous chronic diseases. While acute inflammation serves to neutralize and eliminate harmful stimuli such as pathogens and toxins, failure to resolve these stimuli can lead to chroni...
Transcriptomic analysis suggests ferroptosis as a potential mechanism of fipronil-induced cytotoxicity in human glioblastoma cells [0.03%]
转录组学分析提示铁死亡可能是氟虫腈诱导的人脑胶质母细胞瘤细胞毒性的潜在机制
Yu-Chia Chen,Yu-He Li,Po-Ming Chen et al.
Yu-Chia Chen et al.
Fipronil (FPN), a widely used phenylpyrazole insecticide, has been associated with neurotoxicity. However, the precise molecular mechanisms underlying its effects on human neural cells, particularly glioblastoma, remain poorly understood. T...
Effects of quantum dots on integrin expression and cellular responses in DU145 prostate cancer cells [0.03%]
量子点对DU145前列腺癌细胞中整联蛋白表达及细胞反应的影响
Berta Fal,Magdalena Matysiak-Kucharek,Krzysztof Sawicki et al.
Berta Fal et al.
Quantum dots (QDs) are extensively investigated for biomedical applications, including cancer diagnostics and therapy; however, their potential subcytotoxic effects on cancer cell behavior remain incompletely understood. The aim of this stu...
Sublethal concentrations of PFOS and PFDA differentially impact brood size and gene expression in Caenorhabditis elegans [0.03%]
全氟辛烷磺酸和全氟丁二酸在 subtletal浓度下对秀丽隐杆线虫繁殖力及基因表达的影响不同
Wouter Bakker,David van de Klashorst,Derek Schoots et al.
Wouter Bakker et al.
Although banned in many countries, per- and polyfluorinated alkylated substances (PFAS) persist in the environment, where they pose significant health risks to humans and animals, yet the molecular mechanisms of toxicity remain largely unkn...