Jian-Peng Teoh,Xiaosa Li,Tommaso Simoncini et al.
Jian-Peng Teoh et al.
Gender difference is well recognized as a key risk factor for cardiovascular disease (CVD). Estrogen, the primary female sex hormone, improves cardiovascular functions through receptor (ERα, ERβ, or G protein-coupled estrogen receptor)-in...
Jens Lund,Zachary Gerhart-Hines,Christoffer Clemmensen
Jens Lund
Food intake and energy expenditure are the typical determinants of body weight. Yet, recent observations underscore that a third and often-neglected factor, fecal energy loss, can influence energy balance. Here, we explore how macronutrient...
Sébastien J Dumas,Melissa García-Caballero,Peter Carmeliet
Sébastien J Dumas
Angiogenesis is crucial for the development of the blood vasculature during embryogenesis, but also contributes to cancer and other diseases. While therapeutic targeting of endothelial cells (ECs) through growth factor inhibition is limited...
R Vigneri,L Sciacca,P Vigneri
R Vigneri
In addition to being a major metabolic hormone, insulin is also a growth factor with a mitogenic effect on all cells, more marked in malignant cells that often overexpress the insulin receptor. In patients with metabolic diseases characteri...
Obesity/Metabolic Syndrome and Diabetes Mellitus on Peri-implantitis [0.03%]
肥胖/代谢综合征与糖尿病对 peri-implantitis 的影响
Paula Gabriela Faciola Pessôa de Oliveira,Estevam A Bonfante,Edmara T P Bergamo et al.
Paula Gabriela Faciola Pessôa de Oliveira et al.
Literature has reported that up to 50% of dental implants may be affected by peri-implantitis, a bacteria-induced chronic inflammatory process, which promotes osteoclast-mediated bone resorption and inhibits bone formation, leading to progr...
Ning Dai
Ning Dai
The human insulin-like growth factor 2 (IGF2) mRNA binding protein family (IMPs/IGF2BPs) is involved in a spectrum of biological processes, including development, tumorigenesis, and stemness. IMPs play a major role in post-transcriptional r...
Through the Looking-Glass: Reevaluating DHEA Metabolism Through HSD3B1 Genetics [0.03%]
透过镜子重新评估HSD3B1遗传学中的DHEA代谢
Bryan D Naelitz,Nima Sharifi
Bryan D Naelitz
Dehydroepiandrosterone (DHEA) and DHEA sulfate together are abundant adrenal steroids whose physiological effects are mediated through their conversion to potent downstream androgens. 3β-Hydroxysteroid dehydrogenase isotype 1 (3βHSD1) fac...
Experimental Models of Impaired Hypoglycaemia-Associated Counter-Regulation [0.03%]
实验性低血糖相关反调节功能障碍模型
Adhithya Sankar,Tansi Khodai,Alison D McNeilly et al.
Adhithya Sankar et al.
Impaired awareness of hypoglycaemia (IAH) affects around a quarter of patients with diabetes who receive insulin treatment. This condition is characterised by a progressive reduction in symptomatic and behavioural responses to hypoglycaemia...
Polyphenols as Caloric Restriction Mimetics Regulating Mitochondrial Biogenesis and Mitophagy [0.03%]
多酚作为限制卡路里模拟物调节线粒体生物合成和自噬作用
Sergio Davinelli,Diego De Stefani,Immaculata De Vivo et al.
Sergio Davinelli et al.
The tight coordination between mitochondrial biogenesis and mitophagy can be dysregulated during aging, critically influencing whole-body metabolism, health, and lifespan. To date, caloric restriction (CR) appears to be the most effective i...
Interplay between Clonal Hematopoiesis of Indeterminate Potential and Metabolism [0.03%]
不确定潜能克隆性造血与代谢之间的相互作用
Man K S Lee,Dragana Dragoljevic,Camilla Bertuzzo Veiga et al.
Man K S Lee et al.
Clonal hematopoiesis of indeterminate potential (CHIP), defined as a clone of hematopoietic cells consisting of a single acquired mutation during a lifetime, has recently been discovered to be a major risk factor for atherosclerotic cardiov...