Marlon R Schneider
Marlon R Schneider
Basal metabolism is classically described in terms of oxidative energy expenditure. Here, we propose material-bound energy export as a complementary metabolic fate of biosynthetic products. This framework distinguishes substrate oxidation f...
Giuseppe Maltese,Theocharis Koufakis,Djordje S Popovic
Giuseppe Maltese
Glucagon-like peptide-1 receptor agonists are transforming cardiometabolic care, yet their expanding use in older adults raises an overlooked question: can cardiovascular and renal protection come at the expense of muscle mass, nutritional ...
Helena L Fisk
Helena L Fisk
Obesity leaves a lasting epigenetic imprint on adaptive immunity. A recent work by Niven et al. demonstrates that obesity-associated DNA methylation in CD4+ T lymphocytes persists after weight loss, sustaining inflammatory memory and delayi...
Calcitonin [0.03%]
降钙素
Debbie L Hay,Michael L Garelja
Debbie L Hay
Martina Beretta,Elizabeth J New,Kelsey H Fisher-Wellman et al.
Martina Beretta et al.
Uncontrolled adipose lipolysis is a defining feature of insulin resistance and metabolic disease. Although insulin potently suppresses lipolysis, the mechanisms that override antilipolytic control in insulin resistance remain poorly defined...
Broadcasting live: a genetic proximity labelling mouse model to map cell-specific secretomes [0.03%]
现场直播：构建遗传性接近标记小鼠模型绘制细胞特异性分泌组地图
Cooper T Bowring,Matthew J Watt
Cooper T Bowring
Secreted proteins regulate a range of physiological functions and pathologies; however, identifying these in vivo has been technically challenging. The article by Plucińska et al. introduces a genetically encoded proximity labelling mouse ...
FGF21 [0.03%]
FGF21素ınd;charset=utf-8
Jing Gan,Fan Wu,Zhuofeng Lin
Jing Gan
Sean Y Ng,Christoph Handschin
Sean Y Ng
Exercise stimulates the release of bioactive factors, termed exerkines, that contribute to local and systemic adaptation. Circulating exerkines are often interpreted as direct readouts of muscle secretion, overlooking regulatory processes w...
Calculated free testosterone: rightful heir to the free thyroxine index? [0.03%]
计算所得的游离睾酮：自由甲状腺素指数的正当继承者吗？
Nick Narinx,Leen Antonio,Bruno Lapauw et al.
Nick Narinx et al.
Diagnosis of male hypogonadism relies on combining clinical features and total testosterone (T) measurement. Yet, androgen assessment stands at a familiar crossroads, reminiscent of the thyroxine (T4) era, when total T4 gave way to the free...
Wataru Katano,Atsuki En,Kohta Ikegami
Wataru Katano
Tissue stiffening is widespread in pathology. A new study by Vite et al. reveals a mechanistic link between tissue stiffness and impaired glucose uptake in cardiac muscle cells. The study bridges glucose metabolism and mechanobiology and su...