Martina Beretta,Elizabeth J New,Kelsey H Fisher-Wellman et al.
Martina Beretta et al.
Uncontrolled adipose lipolysis is a defining feature of insulin resistance and metabolic disease. Although insulin potently suppresses lipolysis, the mechanisms that override antilipolytic control in insulin resistance remain poorly defined...
Broadcasting live: a genetic proximity labelling mouse model to map cell-specific secretomes [0.03%]
现场直播：构建遗传性接近标记小鼠模型绘制细胞特异性分泌组地图
Cooper T Bowring,Matthew J Watt
Cooper T Bowring
Secreted proteins regulate a range of physiological functions and pathologies; however, identifying these in vivo has been technically challenging. The article by Plucińska et al. introduces a genetically encoded proximity labelling mouse ...
FGF21 [0.03%]
FGF21素ınd;charset=utf-8
Jing Gan,Fan Wu,Zhuofeng Lin
Jing Gan
Sean Y Ng,Christoph Handschin
Sean Y Ng
Exercise stimulates the release of bioactive factors, termed exerkines, that contribute to local and systemic adaptation. Circulating exerkines are often interpreted as direct readouts of muscle secretion, overlooking regulatory processes w...
Calculated free testosterone: rightful heir to the free thyroxine index? [0.03%]
计算所得的游离睾酮：自由甲状腺素指数的正当继承者吗？
Nick Narinx,Leen Antonio,Bruno Lapauw et al.
Nick Narinx et al.
Diagnosis of male hypogonadism relies on combining clinical features and total testosterone (T) measurement. Yet, androgen assessment stands at a familiar crossroads, reminiscent of the thyroxine (T4) era, when total T4 gave way to the free...
Wataru Katano,Atsuki En,Kohta Ikegami
Wataru Katano
Tissue stiffening is widespread in pathology. A new study by Vite et al. reveals a mechanistic link between tissue stiffness and impaired glucose uptake in cardiac muscle cells. The study bridges glucose metabolism and mechanobiology and su...
A multistakeholder call for belzutifan biomarker data in advanced pheochromocytoma and paraganglioma [0.03%]
多利益攸关方呼吁公布Belzutifan在晚期嗜铬细胞瘤和副神经节瘤中标志物数据
Rodrigo A Toledo,Carlota Arenillas,Patricia L M Dahia;Supporting authors
Rodrigo A Toledo
The HIF-2α inhibitor belzutifan was recently U.S. Food and Drug Administration (FDA)-approved for advanced pheochromocytoma/paraganglioma. This multistakeholder article calls for clinical-trial genomic correlates and outcome data to clarif...
Exercise-evoked immunometabolic niches coordinate context-dependent muscle metabolism [0.03%]
运动诱发的免疫代谢生态位协调肌肉代谢的环境依赖性
Makoto Kanzaki
Makoto Kanzaki
Exercise improves metabolic health; yet paradoxically, many exercise-responsive myokines and immune mediators are also implicated in chronic inflammation and metabolic dysfunction. In this opinion article, we propose that these immune respo...
Kisspeptin [0.03%]
亲吻肽素
João R Neves,Joana Gonçalves
João R Neves
Charles Brenner
Charles Brenner
National Institutes of Health aims to prioritize groundbreaking work that challenges existing views with rigor and reproducibility, and shows potential for translation. Increasingly, however, reviewers penalize applicants for novelty, criti...