The influence of charge and lipophilicity of daunorubicin and idarubicin on their penetration of model biological membranes - Langmuir monolayer and electrochemical studies [0.03%]
多柔比星和伊达比星的电荷和亲脂性对其穿过模型生物膜（Langmuir单层和电化学研究）的影响
Dorota Matyszewska
Dorota Matyszewska
The interactions of two selected anthracyclines, daunorubicin (DNR) and idarubicin (IDA), with phospholipid monolayers used as simple models of cell membranes, were investigated. The results of Langmuir experiments together with Brewster an...
Reversible folding energetics of Yersinia Ail barrel reveals a hyperfluorescent intermediate [0.03%]
耶尔森菌Ail桶状结构可逆折叠热力学及超荧光中间态的发现
Ankit Gupta,Radhakrishnan Mahalakshmi
Ankit Gupta
Deducing the molecular details of membrane protein folding has lately become an important area of research in biology. Using Ail, an outer membrane protein (OMP) from Yersina pestis as our model, we explore details of β-barrel folding, sta...
Hydrogen peroxide permeability of cellular membranes in insulin-producing cells [0.03%]
胰岛素分泌细胞膜过氧化氢通透性研究
Anna Laporte,Stephan Lortz,Christina Schaal et al.
Anna Laporte et al.
Hydrogen peroxide (H2O2) plays a central role in redox signalling and in oxidative stress-mediated cell death. It is generated through multiple mechanisms at various intracellular sites. Due to its chemical stability it can reach distant si...
A comparison of activity, toxicity, and conformation of tritrpticin and two TOAC-labeled analogues. Effects on the mechanism of action [0.03%]
替普汀及其两种TOAC标记类似物的活性、毒性及构象比较研究：对其作用机制的影响
José C Bozelli Jr,Luiz C Salay,Manoel Arcisio-Miranda et al.
José C Bozelli Jr et al.
A strategy that has been gaining increased application for the study of the conformation, dynamics, orientation, and physicochemical properties of peptides is labeling with the paramagnetic amino acid TOAC. This approach was used to gain a ...
Peptide-bicelle interaction: Following variations in size and morphology by a combined NMR-SAXS approach [0.03%]
肽-双胶束相互作用：通过结合NMR-SAXS方法观察大小和形态的改变
E F Dudás,A Wacha,A Bóta et al.
E F Dudás et al.
Changes in membrane properties occurring upon protein interaction are key questions in understanding membrane protein function. To report on the occurring size and shape variation we present here a combined NMR-SAXS method performed under p...
A C-terminal peptide of TFPI-1 facilitates cytosolic delivery of nucleic acid cargo into mammalian cells [0.03%]
一种TFPI-1C端肽促进核酸货物递送至哺乳动物细胞的胞质中
Mobashar Hussain Urf Turabe Fazil,Madhavi Latha Somaraju Chalasani,Yeu Khai Choong et al.
Mobashar Hussain Urf Turabe Fazil et al.
Efficient intracellular nucleic acid delivery into mammalian cells remains a long-standing challenge owing to poor cell permeability and uptake of naked nucleic acids across the cell membrane and limited cargo stability. Conventional delive...
Morphology and dynamics of domains in ergosterol or cholesterol containing membranes [0.03%]
含 Ergosterol 或胆固醇膜中的结构域形态和动力学
Arturo Galván-Hernández,Naritaka Kobayashi,Jorge Hernández-Cobos et al.
Arturo Galván-Hernández et al.
The effect of cholesterol and ergosterol on supported lipid bilayers composed of 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and egg sphingomyelin (eSM) in a 1/1 M ratio was studied using atomic force microscopy. The addition of...
Membrane matters: The impact of a nanodisc-bilayer or a detergent microenvironment on the properties of two eubacterial rhodopsins [0.03%]
膜结构对两种欧菌视紫红质功能和性质的影响：纳米盘与脂双层及去垢剂微环境的比较研究
Srividya Ganapathy,Laura Opdam,Yusaku Hontani et al.
Srividya Ganapathy et al.
Multi-spanning membrane proteins usually require solubilization to allow proper purification and characterization, which generally impairs their structural and functional integrity. We have tested the efficacy of several commonly used deter...
Disruption of palmitate-mediated localization; a shared pathway of force and anesthetic activation of TREK-1 channels [0.03%]
棕榈酸介导定位的干扰；力和麻醉剂激活TREK-1通道的共同途径
E Nicholas Petersen,Mahmud Arif Pavel,Hao Wang et al.
E Nicholas Petersen et al.
TWIK related K+ channel (TREK-1) is a mechano- and anesthetic sensitive channel that when activated attenuates pain and causes anesthesia. Recently the enzyme phospholipase D2 (PLD2) was shown to bind to the channel and generate a local hig...
Investigation of the thermodynamic drivers of the interaction between the high mobility group box domain of Sox2 and bacterial lipopolysaccharide [0.03%]
Sox2高迁移率族盒结构域与细菌脂多糖相互作用的热力学驱动力研究
Patrick H Hewitt,Ernest D Pianim,Nicholas A DiCesare et al.
Patrick H Hewitt et al.
Gastric cancer is associated with high mortality and is preceded by an infection with Helicobacter pylori (H. pylori). H. pylori stimulates inflammation which involves the activation of Toll-like receptor 4 by lipopolysaccharide molecules f...