Molecular dynamic studies on the interaction of a TatA oligomer with Tat translocon substrates [0.03%]
TatA寡聚体与转录激活物-like效应因子AT家族效应蛋白动态相互作用研究
Vinh Tran,Terry M Bricker,Steven M Theg
Vinh Tran
The Tat translocon directly utilizes the Proton Motive Force to transport folded proteins from the n-side to the p-side of energized membranes. In most organisms the translocon consists of three subunits, TatA, TatB and TatC exhibiting a st...
Effects of N-glycosylation on the transport kinetics of organic anion transporting polypeptide (OATP) 1B1 [0.03%]
N-连接糖基化对有机阴离子转运多肽(OATP) 1B1运载动力学的影响
Manami Tanino,Kazunari Tsujii,Hiroki Kataoka et al.
Manami Tanino et al.
Organic anion transporting polypeptide (OATP) 1B1 is crucial for hepatic drug uptake. Three N-glycosylation sites, Asn134, Asn503, and Asn516, have been identified, and substituting the amino acid at these sites with glutamine reduces the e...
Mechanistic insights of arginine-based surfactant interaction with bacteria and mammalian model lipid membranes [0.03%]
基于精氨酸的表面活性剂与细菌和哺乳动物模型脂质膜相互作用的机制见解
Alejandro E Sabatie,Melisa Hermet,María Elisa Fait et al.
Alejandro E Sabatie et al.
Arginine-based surfactants exhibit antimicrobial activity attributed to their positive net charge and amphiphilic nature. These compounds typically disrupt cytoplasmic membranes, leading to cell leakage. We studied the mechanism of action o...
Nanodomain formation in lipid bilayers II: The influence of mixed-chain saturated lipids [0.03%]
混合链饱和脂质对双层脂质纳米域形成的影响II
Deeksha Mehta,Emily H Chaisson,Averi M Cooper et al.
Deeksha Mehta et al.
An important class of lipids found in biological membranes is composed of two structurally different hydrocarbon chains. Among these, low-melting lipids possessing both a saturated and unsaturated chain have been intensely studied because o...
Anke Mautner-Culetto,Marcel Huhn,Simon Schwarz et al.
Anke Mautner-Culetto et al.
The binding of local anesthetics (LAs) to cell membranes is required for LAs to reach the target ion channels, but lipid interactions may also play a role in a purely membrane-mediated mode of activity. Here, we used solid-state NMR and fur...
Reverse micelles produce hydroxyapatite nanoparticles as more efficient gene delivery carriers than regular micelles [0.03%]
反转米勒尔生产羟基磷灰石纳米颗粒作为更有效的基因传递载体而非常规米勒尔
Vuk Uskoković
Vuk Uskoković
Hydroxyapatite (HAp) is an effective inorganic gene delivery carrier due to its ability to transport genetic cargo across cell membranes, protect it from proteolysis, and enable escape from late endosomes via pH-controlled dissolution. Howe...
Nanodomain formation in lipid bilayers I: Quantifying the nanoscopic miscibility transition with FRET [0.03%]
脂质双层中的纳米域形成（一）：用FRET定量表征纳米级互溶度的转变
Emily H Chaisson,Deeksha Mehta,Frederick A Heberle
Emily H Chaisson
We present a robust and easy-to-use methodology for determining the nanoscopic miscibility transition temperature, nm-Tmix, of lipid bilayer mixtures from FRET measurements. The method relies on the use of freely diffusing fluorescent donor...
Effect of ice recrystallization inhibition on hydrogen bonding interactions and membrane leakage of liposomes [0.03%]
冰再结晶抑制对氢键相互作用和脂质体膜泄漏的影响
Dejia Liu,Harriëtte Oldenhof,Harald Sieme et al.
Dejia Liu et al.
In this study effects of ice recrystallization on membrane stability of liposomes were investigated using liposomes encapsulating a fluorescent dye. Membrane leakage was studied after freezing and storage at varying storage temperatures in ...
NMR structural analysis and peptidoglycan binding properties of the peptidoglycan associated lipoprotein (PAL) from Escherichia coli [0.03%]
大肠杆菌肽聚糖结合蛋白(PAL)的核磁共振结构分析及肽聚糖结合性质研究
Ishrat M Jalal,Hiroaki Ishida,Hans J Vogel
Ishrat M Jalal
The peptidoglycan associated lipoprotein (Pal) is crucial in Gram-negative bacteria, participating in outer-membrane integrity and septal wall constriction during cell division. It is also implicated in pathogenesis by mediating sepsis and ...
Blood coagulation protein binds to Ca2+-induced phosphatidylserine nanodomains as revealed by atomic force microscopy [0.03%]
原子力显微镜揭示血液凝固蛋白结合到由Ca2+诱导的磷脂酰丝氨酸纳米区城中
Jie Cheng,Junhong Lü,Xueling Li
Jie Cheng
The interaction between coagulation factor VIII (FVIII) and phospholipid membranes is a critical aspect of the blood clotting process. While it is known that FVIII binds to negatively charged phospholipids, the role of calcium ions (Ca2+) i...