Effects of N-glycosylation on the transport kinetics of organic anion transporting polypeptide (OATP) 1B1
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Organic anion transporting polypeptide (OATP) 1B1 is crucial for hepatic drug uptake. Three N-glycosylation sites, Asn134, Asn503, and Asn516, have been identified, and substituting the amino acid at these sites with glutamine reduces the expression of the OAT... ...
