Molecular dynamics study of SP-B fragment interactions with model lung surfactant bilayers [0.03%]
SP-B片段与肺表面活性剂模型双层相互作用的分子动力学研究
Vahid Sheigani,Abinu Jyothini,Yimiao Zhao et al.
Vahid Sheigani et al.
Respiration depends on a lung surfactant layer to facilitate changes in surface area at the air-water interface. The 79-amino acid lung surfactant protein SP-B, normally present in dimer form, is essential to the functioning of lung surfact...
Phase coexistence in multilayer phospholipid films treated with certain cryoprotectants [0.03%]
某些冻存保护剂处理的多层磷脂薄膜中的相共存现象
Yulia V Zaytseva,Konstantin A Okotrub,Nikolay V Surovtsev
Yulia V Zaytseva
The interaction of cryoprotective agents (CPAs) with complex phospholipid bilayers, crucial for cryopreservation, remains understudied beyond single-component models. We applied Raman mapping to multilayer films of DOPC/DPPC-d62/Chol = 1/3/...
How receptor conformation depends on lipid nanodisc size: Adenosine A2A receptor and implications for class-A GPCR proteins [0.03%]
受体构象依赖脂质纳米盘大小：腺苷A2A受体及其对A类G蛋白偶联受体的启示
Veera Hägg,Ilya Levental,Shreyas Kaptan et al.
Veera Hägg et al.
Nanodiscs have become an exceptionally valuable tool to explore membrane proteins in an environment resembling native membranes. However, it remains unclear how well the lipid nanodisc environment matches the conditions under which membrane...
Heme signaling through the cytochrome c-like domain of the human BK channel [0.03%]
人BK通道的细胞色素c样结构域介导的血红素信号转导
Fidan Gudratova,Nicoletta Savalli,Aysel Aliyeva et al.
Fidan Gudratova et al.
Large-conductance voltage- and Ca2+-activated potassium channels (BK channels) are key regulators of cellular excitability and are modulated by various signaling molecules, including heme. However, direct evidence for heme binding to BK cha...
Membrane composition and osmotic conditions jointly regulate encapsulation and translation efficiency in GUV based artificial cells [0.03%]
人工细胞中包裹效率和翻译效率由膜组成及渗透条件共同调节
Gakushi Tsuji
Gakushi Tsuji
Giant unilamellar vesicles (GUVs) are widely used as cell-sized compartments for artificial cell models that encapsulate transcription and translation reactions. Although isotonic sugar conditions between inner and outer aqueous phases are ...
Alpha synuclein variants significantly influence the propensity for clustering and pore formation in giant unilamellar vesicles [0.03%]
α-突触核蛋白变异体显著影响巨单层脂质体聚集和孔道形成的倾向性
Surajit Das,Rajeev Jain,Krishnananda Chattopadhyay et al.
Surajit Das et al.
Alpha-synuclein (α-syn), a presynaptic neuronal protein, is believed to play significant roles in Parkinson's disease (PD), the second most common neurodegenerative disorder. An aberrant aggregation of fibrillar form within Lewy bodies is ...
Georg Pabst,Carolyn Vargas,Sandro Keller
Georg Pabst
Biological membranes are among the most complex and functionally versatile structures in living cells. In this Perspective, dedicated to the memory of Joachim Seelig, we explore ten questions that, in our view, define the current frontiers ...
Bicelles stabilize a compact conformation of opsin with enhanced α-helical packing [0.03%]
双层液晶体膜稳定视黄醛脱辅酶 Opsin 紧凑的构象并增强其α-螺旋状包合
Patryk Kamil Bielski,Justyna Bożek,Valerio Marino et al.
Patryk Kamil Bielski et al.
Bicelles form a disc-like planar lipid bilayer surrounded by short-chain lipids at the peripheral rim. Therefore, they are well-suited to study purified transmembrane proteins in a more native-like environment. In this study, we investigate...
CATpie: A Python tool for quantifying membrane curvature, area, and geometrically faithful normal-line thickness from molecular dynamics simulations [0.03%]
CATpie：一种从分子动力学模拟量化膜曲率、面积和几何上忠实的法线厚度的Python工具
Ali Asghar Hakami Zanjani
Ali Asghar Hakami Zanjani
Membrane shape is commonly described by curvature, area, and thickness, which underpin bilayer mechanics and protein-membrane interactions. In molecular dynamics (MD) simulations, these quantities must be inferred from discrete coordinates,...
Pore-level quantitative structure-activity relationship (QSAR) for water permeation rate in aquaporins [0.03%]
水通道蛋白中水分渗透率的孔水平定量结构活性关系（QSAR）研究
Juan José Galano-Frutos,Luca Bergamasco,Paolo Vigo et al.
Juan José Galano-Frutos et al.
Aquaporins (AQPs) and aquaglyceroporins (AQGPs) play a crucial role in regulating water transport and solute selectivity across biological membranes. Besides their biological relevance, AQPs have attracted growing interest as models for the...