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Alpha synuclein variants significantly influence the propensity for clustering and pore formation in giant unilamellar vesicles

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Alpha-synuclein (α-syn), a presynaptic neuronal protein, is believed to play significant roles in Parkinson's disease (PD), the second most common neurodegenerative disorder. An aberrant aggregation of fibrillar form within Lewy bodies is the main neuropatho... ...