Mechanistic evaluation of liposome-amyloid composite nanocarriers for doxorubicin delivery: Linking release kinetics with pharmacokinetic behavior [0.03%]
用于多柔比星递送的脂质体-淀粉样复合纳米载体的机制评价：结合释放动力学与药代动力学行为
Valeriya Trusova,Uliana Malovytsia,Olga Zhytniakivska et al.
Valeriya Trusova et al.
The present study extends our previous experimental investigation of liposome-amyloid composite nanocarriers for doxorubicin (DOX) delivery by providing a mechanistic analysis of how experimentally observed loading and release parameters in...
Erick J Dufousrc,Burkhard Bechinger
Erick J Dufousrc
Effect of Ca2+ and Mg2+ on the conformational dynamics of membrane-anchored Bcl-xL [0.03%]
Ca²⁺和Mg²⁺对膜锚定的Bcl-xL构象动力学的影响
Quynh Nguyen,J Alfredo Freites,Alexey S Ladokhin et al.
Quynh Nguyen et al.
Mg2+ and Ca2+ are involved in nearly every aspect of cellular function. These divalent cations can bind to the same protein binding sites, often with significantly binding affinities, resulting in distinct conformational changes in proteins...
Compositional analysis and functional insights of the cell envelope in Synechocystis sp. PCC 6803 [0.03%]
鞘氨醇甘油二脂质合成酶PgDgs3在集胞藻细胞壁中的定位及分泌型鞘氨醇甘油二脂质合成酶的挖掘与鉴定
Dario Piano,Patrycja Haniewicz,Domenica Farci
Dario Piano
The cell envelope of Synechocystis sp. PCC 6803 has a Gram-negative-like organization, with inner and outer membranes and an outermost surface layer. A comprehensive characterization of its layered structure, considering the presence of pig...
From membrane disruption to intracellular targets: A solid-state NMR perspective on antimicrobial peptide mechanism [0.03%]
从膜破坏到细胞内靶点——抗菌肽作用机制的固态NMR研究视角
Yijin Zhang,Yajing Zou,Jun Yang
Yijin Zhang
Antimicrobial peptides (AMPs) are promising alternatives to conventional antibiotics due to their broad-spectrum activity and low tendency to induce resistance. Based on their modes of action, AMPs are generally classified as membrane-activ...
The human adenosine A2A receptor co-isolates with anionic phospholipids in SMALPs from Pichia pastoris membranes [0.03%]
酿酒酵母膜中的SMALP分离的人类腺苷A2A受体与阴离子磷脂共隔离
Idoia Company Marín,Andrew R Pitt,Corinne M Spickett
Idoia Company Marín
The adenosine A2A receptor (A2AR) is a GPCR that binds adenosine, leading to modulation of inflammation, platelet aggregation and vasodilation of coronary arteries. It is known that phospholipids surrounding GPCRs affect their activity but ...
Michael F Brown
Michael F Brown
Cellular lipids are wonders of biomolecular self-organization whose structure and dynamics are intimately connected with their functionality. Here we review the development and use of NMR spectroscopy in the study of lipid membranes. For li...
Exposure to the antimicrobial peptides LL-37 and ATRA-1 induces a lipidome response in Staphylococcus aureus that alters membrane biophysical properties [0.03%]
抗菌肽LL-37和ATRA-1对金黄色葡萄球菌脂质组的影响及其改变细胞膜生物物理性质的作用机制研究
Christian Fuertes-Chaves,Juan E Gonzalez,Elizabeth Suesca et al.
Christian Fuertes-Chaves et al.
Staphylococcus aureus (S. aureus) is an opportunistic pathogen that is a global health concern for its ability to cause a wide spectrum of clinical infections ranging from minor skin abscesses to systemic conditions such as sepsis and pneum...
Lysine is more effective than arginine in two tryptophan-rich antimicrobial peptides [0.03%]
赖氨酸比精氨酸更有效于两种富含色氨酸的抗菌肽中
Ashley Hackney,Logan Hartmann,Rohan Parasnis et al.
Ashley Hackney et al.
We compare biophysical and microbiological results to link structure and function in determining the mechanism of bacterial killing by two antimicrobial peptides (AMPs). Two 14-mer peptides were compared, each containing 6 tryptophans, in a...
Comparative analysis of nucleic acid delivery systems based on benzimidazolium surfactants: impact of auxiliary lipids on lipoplex internalization and functional gene delivery in cancer cells [0.03%]
基于苯并咪唑𬭩表面活性剂的核酸递送体系的比较分析：辅助脂质对癌细胞中脂质复合物内吞及功能基因递送的影响
Darya A Kuznetsova,Denis M Kuznetsov,Anna P Lyubina et al.
Darya A Kuznetsova et al.
The design of effective non-viral nucleic acid delivery systems based on cationic amphiphilic compounds remains a major challenge in biomedical research. In this study, cationic benzimidazolium surfactants (BI-n) and cationic liposomes comp...