Structural modification of lipid membranes by polyphenols: A fluorescence spectroscopy study [0.03%]
利用荧光光谱法研究多酚对脂质膜的结构修饰作用
Valeriya M Trusova,Uliana K Tarabara,Mette H Thomsen et al.
Valeriya M Trusova et al.
The present study investigates the molecular mechanisms of polyphenol-lipid interactions and their impact on membrane properties. Using pyrene and DPH as reporter molecules, we examined the impact of quercetin, curcumin, gallic, and salicyl...
Differential effects of endo- and exopolyphosphatase expression on the induction of the mitochondrial permeability transition pore [0.03%]
内聚磷酸酶和外切聚磷酸酶表达对线粒体渗透性转换孔诱导的不同影响
Yaw Akosah,Vedangi Hambardikar,Maria Neginskaya et al.
Yaw Akosah et al.
Inorganic polyphosphate (polyP) is a polymer that consists of a series of orthophosphates connected by high-energy phosphoanhydride bonds, like those found in ATP. In mammalian mitochondria, polyP has been linked to the activation of the mi...
Improving the antimicrobial potential of the peptide CIDEM-501 through acylation: A computational approach [0.03%]
酰化改进肽CIDEM-501的抗菌潜力：一种计算方法
Daniel Alpízar-Pedraza,Adrian Romero-Rivero,Rolando Perdomo-Morales et al.
Daniel Alpízar-Pedraza et al.
Acylation is a common method used to modify antimicrobial peptides to enhance their effectiveness. It increases the interactions between the peptide and the bacterial cell membranes. However, acylation can also reduce the selectivity of the...
Elucidating the structure and function of a membrane-active plant protein domain using in silico mutagenesis [0.03%]
基于计算机的突变分析阐释植物膜活性蛋白结构域的功能及作用机制
Lennie K Y Cheung,Sebastian Thallmair,Rickey Y Yada
Lennie K Y Cheung
The Solanum tuberosum (common potato) plant specific insert (StPSI) is an antimicrobial protein domain that exhibits membrane-disrupting and membrane-fusing activity upon dimerization at acidic pH, activity proposed to involve electrostatic...
Differential insertion of arginine in saturated and unsaturated lipid vesicles [0.03%]
精氨酸在饱和及不饱和脂质囊泡中的不同插入行为
Hugo A Perez,María A Brandan,Aníbal Disalvo et al.
Hugo A Perez et al.
In this work, the effects of L- Arginine (L-Arg) insertion on saturated and unsaturated lipid membranes were assessed by fluorescence spectroscopy, dynamic light scattering (DLS) and monolayer measurements. The studied systems were composed...
Characterization of intact FeoB in a lipid bilayer using styrene-maleic acid (SMA) copolymers [0.03%]
基于聚苯乙烯马来酸共聚物的脂质双层中完整FeoB蛋白的表征研究
Mark Lee,Candice M Armstrong,Aaron T Smith
Mark Lee
The acquisition of ferrous iron (Fe2+) is crucial for the survival of many pathogenic bacteria living within acidic and/or anoxic conditions such as Vibrio cholerae, the causative agent of the disease cholera. Bacterial pathogens utilize ir...
Identification of a sorting motif for Tspan3 to MHCII compartments in human B cells [0.03%]
人类B细胞中Tspan3至MHCII区室的分选基序鉴定
Fabian Schwerdtfeger,Martin Ter Beest,Cesar A Perez-Martinez et al.
Fabian Schwerdtfeger et al.
Tetraspanins are four-transmembrane proteins that play fundamental roles in the immune system by enabling processes like migration, proliferation, signaling and protein trafficking. While the importance of cell surface tetraspanins has been...
Phase-separated cationic giant unilamellar vesicles as templates for the polymerization of tetraethyl orthosilicate (TEOS) [0.03%]
相分离的阳离子大单层囊泡作为四乙氧基硅烷(TEOS)聚合的模板
Kohei Shiomi,Keita Hayashi,Haruyuki Ishii et al.
Kohei Shiomi et al.
Unlike homogeneous liposomes, phase-separated liposomes have the potential to be attractive soft materials because they exhibit different properties for each phase. In this study, phase separation was observed when liposomes were prepared u...
Nanodomains enriched in arachidonic acid promote P2Y12 receptor oligomerization in the platelet plasma membrane [0.03%]
富含花生四烯酸的纳米域促进血小板质膜中P2Y12受体寡聚化
Florentin Allemand,Semen Yesylevskyy,Jennifer Lagoutte-Renosi et al.
Florentin Allemand et al.
P2Y12 receptors on the platelet plasma membrane are targeted by several antiplatelets drugs. Although oligomerization and functioning of P2Y12 receptors depend on the membrane environment, little is known about their preferred membrane loca...
Bea Berner,Georgia Daoutsali,Emilia Melén et al.
Bea Berner et al.
ATP-binding cassette (ABC) transporters are proteins responsible for active transport of various compounds, from small ions to macromolecules, across membranes. Proteins from this superfamily also pump drugs out of the cell resulting in mul...