A brief history of phosphatidylinositol transfer proteins: from the backwaters of cell biology to prime time in lipid signaling [0.03%]
磷脂酰肌醇转移蛋白的简史：从细胞生物学的边缘到脂质信号传导的核心
Vytas A Bankaitis,Danish Khan,Xiao-Ru Chen et al.
Vytas A Bankaitis et al.
How lipids are sorted between intracellular compartments and what mechanisms support inter-organellar lipid transport define questions that have enjoyed long-standing interest in the cell biology community. Despite tantalizing evidence to t...
Phosphoinositide-specific phospholipase C enzymes: Recent advances in a long journey [0.03%]
磷脂酶C家族蛋白的最新研究进展
Calum Macrae,Damjan Lalović,Tom D Bunney et al.
Calum Macrae et al.
A journey that started with the discovery of phospholipase C catalysed inositol-lipid hydrolysis as a receptor-controlled signalling event, culminated in defining molecular properties and roles of phosphoinositide-specific phospholipase C (...
Maria Antonietta De Matteis,Marianna Fico,Rossella Venditti
Maria Antonietta De Matteis
Fifty years after Bob Michell's visionary prediction, phosphatidylinositol 4-phosphate (PI4P) has emerged as a central regulator of Golgi function, influencing membrane trafficking, lipid metabolism, and signaling. PI4P homeostasis is tight...
Advances in lipid research: From bench to bedside: A special issue dedicated to the 63rd International Conference on the Bioscience of Lipids [0.03%]
脂质研究进展：从实验台到病床——第六届国际脂质生物科学大会特刊
Gwendolyn Barceló-Coblijn,Jesús Balsinde
Gwendolyn Barceló-Coblijn
Endogenous LC-PUFA biosynthetic capability in dwarf surf clam Mulinia lateralis: characterization and functional analysis of fatty acyl elongases and a desaturase [0.03%]
凡纳短指樱蛤内源性LC-PUFA生物合成能力研究：脂肪酰基延长酶和脱氢酶的鉴定与功能分析
Zhenghua Zheng,Na Liu,Weiping Ren et al.
Zhenghua Zheng et al.
Elongases of very long-chain fatty acids (Elovls) and fatty acyl desaturases (Fads) are two key enzymes in the biosynthesis of long-chain polyunsaturated fatty acids (LC-PUFAs). Here, we identified and characterized five Elovl genes (MulElo...
Loss of the acyltransferase TMEM68 leads to growth delay and dysregulation of triacylglycerol and glycerophospholipid homeostasis in the mouse brain [0.03%]
酰基转移酶TMEM68的丧失导致小鼠大脑生长迟缓及三酰甘油和甘油磷脂稳态失调
Chunyan Zhang,Tingting Li,Christoph Heier et al.
Chunyan Zhang et al.
Lipid droplets (LDs) are ubiquitous cellular storage organelles for triacylglycerol (TAG) that have recently been implicated in brain development and aging, and the progression of neurodegenerative diseases. However, the enzymes responsible...
Lipidome plasticity in medium- and long-chain fatty acid oxidation disorders: Insights from dried blood spot lipidomics [0.03%]
中链和长链脂肪酸氧化障碍中的脂质组可塑性：来自干血斑脂质组学的见解
Inês M S Guerra,Hugo Rocha,Sónia Moreira et al.
Inês M S Guerra et al.
Fatty acid (FA) oxidation disorders (FAOD) are characterized by accumulation of specific acylcarnitines (CAR) and FA and can lead to potentially severe complications. In this study, dried blood spots (DBS) combined with LC-MS lipidomics ana...
Luteolin, as a bidirectional ROS regulator, elevates mouse beige adipocyte browning [0.03%]
黄酮类化合物山柰素通过双向调节ROS提高小鼠米色脂肪细胞褐变效应
Zhixin Zhang,Linli Zhao,Jiahui Wang et al.
Zhixin Zhang et al.
In beige adipocytes, UCP1-dependent thermogenesis can be driven by intracellular reactive oxygen species (ROS) generation. While ROS elevation also induces mast cell activation, serotonin synthesis and release from mast cells inhibits beige...
Wafa&#x;a Hajeer,Amparo Blanco,Anthony P Miller et al.
Wafa&#x;a Hajeer et al.
Carotenoids are a class of pigments with antioxidant properties synthesized by photosynthetic and heterotrophic organisms. Humans can store carotenoids in their intact form or cleave them enzymatically to apocarotenoids such as vitamin A, a...
Methyl-end desaturases determine the capability for de novo biosynthesis of polyunsaturated fatty acids in bivalves [0.03%]
甲基末端去饱和酶决定双壳纲动物从头合成多不饱和脂肪酸的能力
Naoki Kabeya,Marc Ramos-Llorens,Yo Nakano et al.
Naoki Kabeya et al.
Recent studies have shown that many invertebrate species possess methyl-end desaturases (herein referred to as 'ωx'), enabling biosynthesis of polyunsaturated fatty acids (PUFA). However, the phylogenetic distribution of these enzymes acro...