Combination of hydroxycitric acid and capsaicin regulates IRS-1/AMPK-mTOR-SREBP-1c Axis/NLRP3-NF-κB/Nrf-2-ARE signaling pathways to ameliorate the two-hit process in high-fat diet-induced hepatic steatosis [0.03%]
羟基柠檬酸和辣椒素通过调节IRS-1/AMPK-mTOR-SREBP-1c轴/NLRP3-NF-κB/Nrf-2-ARE信号通路缓解高脂饮食诱导的二次打击肝脂肪变性过程
V V Sathibabu Uddandrao,Deepthi Krishna,M N Vasantha et al.
V V Sathibabu Uddandrao et al.
Metabolic (Dysfunction) Associated Steatotic Liver Disease (MASLD) is a complex metabolic condition, the progression of which toward steatohepatitis can be explained by the 'two-hit' hypothesis: the first hit involves lipid accumulation, an...
Modulation of lipid droplet biogenesis by p38 MAPK and caspase-1 in docosahexaenoic acid-induced EA.hy926 endothelial cell apoptosis [0.03%]
花生四烯酸诱导的内皮细胞凋亡中p38MAPK和Caspase-1对脂滴生物发生的作用
Youjia Du,Xucheng Lv,Yan Shen et al.
Youjia Du et al.
Endothelial cells form a single layer of endothelium that lines the inner surface of the blood vessels. Healthy endothelial cells play important roles in the maintenance of the circulation homeostasis, while endothelial cell apoptosis has b...
Sterol analysis of MARCHF6-deficient cells reveals a new pinch point in the cholesterol biosynthesis pathway [0.03%]
sterol分析揭示了MARCHF6缺陷细胞中胆固醇生物合成途径中的一个新的瓶颈点
Nicole M Fenton,Laura J Sharpe,Andrew M Jenner et al.
Nicole M Fenton et al.
Echinacoside suppresses macrophage lipid accumulation and attenuates atherosclerosis via the MDM2/PPARγ/ABCA1 signaling axis [0.03%]
雷公藤内酯通过MDM2/PPARγ/ABCA1信号轴抑制巨噬细胞脂质积累和动脉粥样硬化形成
Qin-Yi Zhou,Jing Zhou,Zhao-Bing Li et al.
Qin-Yi Zhou et al.
Macrophage cholesterol efflux, a critical step in reverse cholesterol transport, plays a pivotal role in the attenuation of atherosclerosis. Echinacoside, a natural compound with anti-inflammatory, antioxidant, and antitumor properties, has...
Lipid metabolic adaptations of multi-donor mesenchymal stem cells during osteodifferentiation [0.03%]
多供者间充质干细胞成骨分化的脂代谢适应性研究
Daniela S C Bispo,Inês Graça,Catarina S H Jesus et al.
Daniela S C Bispo et al.
Mesenchymal stem cell (MSC) osteodifferentiation is accompanied by important lipid metabolic adaptations, which may reveal relevant biomarkers and potential osteoinductive species. However, high donor variability remains a challenge for bio...
Distinct lipidomic profiles in breast cancer cell lines relate to proliferation and EMT phenotypes [0.03%]
与增殖和上皮间质转化表型相关的乳腺癌细胞系具有不同的脂质组学谱型
Hanneke Leegwater,Zhengzheng Zhang,Xiaobing Zhang et al.
Hanneke Leegwater et al.
Rewiring of lipid metabolism is a hallmark of cancer, supporting tumor growth, survival, and therapy resistance. However, lipid metabolic heterogeneity in breast cancer remains poorly understood. In this study, we systematically profiled th...
Galectin-3 gene deletion alters lipid profile in healthy and cardiomyopathy mouse hearts [0.03%]
半乳糖凝集素-3基因缺失可改变健康及心肌病小鼠心脏脂质谱特征
Xiao-Jun Du,Kevin Huynh,Mark Ziemann et al.
Xiao-Jun Du et al.
Galectin-3 (Gal3) is known to interact with glycans of proteins and lipids. In cardiovascular disease, the elevated expression of Gal3 mediates inflammation, hypertrophy and fibrosis. We explored the effect of Gal3 on the cardiac lipid prof...
The influence of soluble epoxide hydrolase inhibition and their PUFA-derived epoxides in osteoblast bone metabolism: an in vitro study [0.03%]
可溶性环氧合酶抑制剂及其多不饱和脂肪酸衍生物对成骨细胞骨代谢影响的体外实验研究
Duilio Benicio E Silva-Junior,Ney Robson Bezerra Ribeiro,David Martins Nunes Junior et al.
Duilio Benicio E Silva-Junior et al.
EpFAs are crucial mediators in resolving inflammation and regulating various biological processes. However, their activity is constrained by the rapid metabolism mediated by the soluble epoxide hydrolase (sEH), which converts EpFAs into ina...
Recombinant hirudin prevents against nonalcoholic fatty liver disease by modulating PAR1/JAK2/STAT5/STAT3/CD36 pathway [0.03%]
重组水蛭素通过调节PAR1/JAK2/STAT5/STAT3/CD36信号通路预防非酒精性脂肪肝病
Y U Xiaoyu,Yi Sun,Changyuan Wang et al.
Y U Xiaoyu et al.
Background: Non-alcoholic fatty liver disease (NAFLD) has become a common liver disease. Recombinant hirudin (R-Hirudin) is an manufactured product produced by genetic engineering technology which possesses antithrombotic...
The individual isoforms of ORMDL, the regulatory subunit of serine palmitoyltransferase, have distinctive sensitivities to ceramide [0.03%]
ORMDL的各个同种型（丝氨酸棕榈酰转移酶调控亚基）对鞘氨醇具有特异敏感性
Usha Mahawar,Deanna L Davis,Muthukumar Kannan et al.
Usha Mahawar et al.
Sphingolipids play crucial roles in cell membrane structure and in multiple signaling pathways. Sphingolipid de novo biosynthesis is mediated by the serine palmitoyltransferase (SPT) enzyme complex. Homeostatic regulation of this complex is...