Editorial: Celebrating 50 Years of Insight-Bob Michell's Legacy in Phosphoinositide Signalling [0.03%]
庆祝《信号转导》创刊50周年：Bob Mitchel爵士在磷脂酰肌醇信号传导领域的影响与传承
Shamshad Cockcroft,Phillip Hawkins,Len Stephens et al.
Shamshad Cockcroft et al.
Roles in physiology and disease of the inositol phosphatase synaptojanin 1 [0.03%]
肌醇磷酸酶synaptojanin 1的生理及病理作用
Pietro De Camilli
Pietro De Camilli
Synaptojanin 1 (Synj1) is a protein highly enriched in the nervous system which comprises tandemly arranged inositol 4-phosphatase and 5-phosphatase domains. Since its discovery as a synaptically enriched binding partner of SH3 domain conta...
Phosphoinositides at 50: From minor lipids to master organizers of polarity [0.03%]
磷脂酰肌醇五十年——从次要脂质到极性调控的主要组织者
Ama Gassama-Diagne
Ama Gassama-Diagne
Phosphoinositides (PIs) have been at the center of cell signaling and membrane biology since Michell's proposal of the PI-cycle in 1975. Over the past fifty years, these quantitatively minor lipids have emerged as versatile molecular organi...
Morgan M C Ricci,Claire C Weckerly,Gerald R V Hammond
Morgan M C Ricci
Phosphoinositides (PPIn) are low-abundance phospholipids that define membrane identity and direct compartment-specific signaling across eukaryotic cells. Marking fifty years since Michell's seminal 1975 review, we re-evaluate how the subcel...
ATGL-mediated lipolysis is essential for myocellular mitochondrial function, mitochondria-lipid droplet interaction and mitochondrial network connectivity [0.03%]
ATGL介导的脂解对维持肌细胞线粒体功能、线粒体-脂滴相互作用及线粒体网络连接是必需的
Anne Gemmink,Tineke van de Weijer,Gert Schaart et al.
Anne Gemmink et al.
Defects in Adipose tissue TriGlyceride Lipase (ATGL)-mediated myocellular lipid droplet (LD) lipolysis results in mitochondrial dysfunction of unknown origin, which can be rescued by PPAR agonists. Here we examine if ATGL-mediated lipolysis...
Sphinganine-induced lysosomal membrane permeabilization: Interplay with subcellular oxidative levels [0.03%]
鞘氨醇诱导的溶酶体膜透化：与亚细胞氧化水平的相互作用
Guodong Cheng,Changxi Qi,Huiling Xu et al.
Guodong Cheng et al.
Sphinganine (SA), a fundamental sphingolipid whose cytotoxicity remains incompletely characterized, has received less attention compared to other sphingoid bases. Here, we demonstrate that SA predominantly triggers cell death via lysosomal ...
Melatonin ameliorates ox-LDL-induced lipid accumulation and enhances ABCA1 expression in VSMCs via inhibition of the TRPV1-Ca2+-calpain signaling pathway [0.03%]
褪黑素通过抑制TRPV1-Ca2+-钙蛋白酶信号途径缓解氧化低密度脂蛋白诱导的血管平滑肌细胞内脂质蓄积并增强其ABCA1表达
Yuehong Tang,Yujiao Peng,Yaling Zhang et al.
Yuehong Tang et al.
Oxidized low-density lipoprotein (ox-LDL) has been shown to induce significant lipid accumulation and disrupt cholesterol homeostasis in vascular smooth muscle cells (VSMCs), which may contribute to the development of atherosclerosis (AS). ...
Functional analysis and regulation mechanism of FGF19 on lipid metabolism in liver of large yellow croaker (Larimichthys crocea) [0.03%]
FGF19对大黄鱼肝脏脂代谢的功能及调控机制分析
Jianlong Du,Yuning Sun,Jinze Zhang et al.
Jianlong Du et al.
Fibroblast growth factor 19 (FGF19) is a key intestinally secreted factor in mammals, its physiological role in teleost remains largely unclear. This study aimed to investigate the function and underlying mechanisms of FGF19 in the regulati...
Regulation of macroautophagy and microautophagic lipophagy by phosphatidylserine synthase Cho1 and external ethanolamine [0.03%]
卵磷脂合成酶Cho1和外源乙醇胺调控巨自噬和微自噬脂自噬作用
Nanaru Mineoka,Rikako Konishi,Yuri Nakashima et al.
Nanaru Mineoka et al.
Phospholipids play crucial roles in autophagy; however, the underlying mechanisms remain elusive. We previously found that the phosphatidylserine (PtdSer) transporter Osh5 is critical for autophagosome formation. Therefore, in this study, w...
Induction of lipid autophagy by chitosan-coated selenium nanoparticles mitigates NAFLD in vitro and in vivo [0.03%]
壳聚糖硒纳米颗粒诱导脂质自噬可改善体外和体内的非酒精性脂肪肝病
Yanqiu Zhu,Yihan Wang,Chenglong Xia et al.
Yanqiu Zhu et al.
Excessive lipid accumulation within the liver is a main factor inducing non-alcoholic fatty liver diseases (NAFLD). Chitosan coated selenium nanoparticles (CS-SeNPs), a new kind of selenium supplement. In vitro study, CS-SeNPs remarkably de...