The pivotal role of cholesterol metabolism in peripheral nerve regeneration [0.03%]
胆固醇代谢在周围神经再生中的关键作用
Kun Guo,ShuLang He,Di Song et al.
Kun Guo et al.
Peripheral nerve injury (PNI) remains a significant clinical challenge due to the difficulty in achieving complete structural and functional recovery after injury. Recent studies have demonstrated that cholesterol metabolism serves not only...
Decreased 13-HODE as a metabolic signature of enhanced lipid peroxidation in hypertriglyceridemic pancreatitis [0.03%]
高甘油三酯血症性胰腺炎中13-HODE降低作为脂质过氧化增强的代谢标志物
Qi Qiu,Wanmeng Li,Jing Chen et al.
Qi Qiu et al.
The global incidence of hypertriglyceridemic pancreatitis (HTGP) is increasing, particularly in China, highlighting the urgent need to understand its pathogenesis. Given the metabolic basis of HTGP, this study aimed to define its specific m...
Remodeling of lipid metabolism orchestrates human adipose-derived mesenchymal stem cells osteodifferentiation [0.03%]
脂质代谢重塑调控人脂肪源间充质干细胞成骨分化
Daniela S C Bispo,Jennifer H Haggarty,Inês Graça et al.
Daniela S C Bispo et al.
Mesenchymal stem cell (MSC) osteodifferentiation involves adaptations of lipid metabolism but the specific regulatory roles of lipid species remain underexplored. We use a global metabolomics approach, comprising LC-MS lipidomics and NMR me...
Lipidomic and transcriptomic reveals glycerophospholipid and sphingolipid disorders in CVB3 induced viral myocarditis [0.03%]
脂质组学和转录组学揭示了CVB3诱导的心肌炎中甘油磷脂和鞘脂代谢紊乱
Mengying Zhang,Hongyan Yao,Zhiyong Zhao et al.
Mengying Zhang et al.
Lipids, which possess a variety of physiological functions, have been demonstrated to be involved in the development of CVB3-induced viral myocarditis (VM). Nevertheless, the dynamic changes of lipid in VM, along with the underlying mechani...
Diverse methyl-end desaturases enable LC-PUFA biosynthesis across Annelida [0.03%]
甲壳素末端去饱和酶多样性使环节动物长链多不饱和脂肪酸生物合成成为可能
Wen-Xuan Xu,Marc Ramos-Llorens,Naoki Kabeya et al.
Wen-Xuan Xu et al.
Recent studies have demonstrated that annelids possess front-end desaturases and elongases involved in the biosynthesis of physiologically important long-chain polyunsaturated fatty acids (LC-PUFA). However, methyl-end desaturases (ωx desa...
Futile cycles in metabolic flexibility: The energetic cost of regulatory precision [0.03%]
代谢灵活性中的无用循环：调控精确性的能耗成本
Radhika Khandelwal,Lianggong Ding,Anand Kumar Sharma
Radhika Khandelwal
Futile cycles (FCs), also known as substrate cycles, are a pair of opposing biochemical reactions that continually convert a substrate into a product and back. In doing so, FCs waste ATP without producing a tangible metabolic output (thus t...
Fructooligosaccharides ameliorate hepatic and renal lipid accumulation and intestinal barrier dysfunctions in a pre-diabetic rat model [0.03%]
低聚果糖通过改善肠道屏障功能障碍减轻糖尿病前期大鼠肝肾脂质蓄积效应
Nattavadee Pengrattanachot,Onanong Jaruan,Sasivimon Promsan et al.
Nattavadee Pengrattanachot et al.
Consumption of a high-fat diet (HFD) diet is a factor associated with several diseases including obesity and its associated complications, especially liver and kidney dysfunction via promoting derangement of lipid metabolism. It has been re...
YAP/TAZ knockdown reduces lipid droplet accumulation in hepatic cells through a putative SBDSP1/miR-29a-5p/LDLR regulatory axis [0.03%]
YAP/TAZ敲低通过疑似SBDSP1/miR-29a-5p/LDLR调节轴减少肝细胞脂滴聚集
Merna H Hamad,Fabian Rose,Manon Ragheb et al.
Merna H Hamad et al.
Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are central downstream effectors of the Hippo pathway and play key roles in hepatic metabolic regulation. However, the molecular mechanisms by which ...
Moderate-altitude hypoxia is associated with attenuated diet-induced liver injury and coordinated carbon-metabolic and lipid remodeling [0.03%]
中等海拔缺氧可减轻饮食引起的肝损伤并协调碳代谢和脂质重塑
Yanyan Ma,Erwa Hao,Tao Zhang et al.
Yanyan Ma et al.
Chronic mild hypoxia at moderate altitude (2260 m) has been linked to improved systemic metabolism, but its liver-specific associations under high-energy diets remain incompletely defined. In this study, age-matched male C57BL/6 J mice were...
The gut microbial lauroyl tryptamine antagonizes oxysterol-GPR183 signaling to modulate lipid-sensitive metabolic pathways in a sex-dependent manner [0.03%]
肠道微生物十四烷酰色胺通过对抗氧化固醇-GPR183信号通路以性别依赖性方式调节脂敏感代谢途径
Liv von Voss,Viktoria M S Kjær,Mark M Smits et al.
Liv von Voss et al.
Objectives: GPR183, a G protein-coupled receptor activated by oxysterols, regulates immune and metabolic signaling in a sex-dependent manner. Lauroyl tryptamine (LT), a lipid-modified microbial metabolite, was recently id...