Palmitoyl-protein thioesterase 1 mediated depalmitoylation regulates lipid accumulation in the oleaginous fungus Mucor circinelloides [0.03%]
棕榈酰蛋白硫酯酶 1 介导的去棕榈酰化调控产油真菌穆氏腐皮壳中脂质积累
Hequn Li,Zhen Wang,Hongjuan Yuan et al.
Hequn Li et al.
Palmitoyl-protein thioesterase 1 (PPT1), a key depalmitoylating enzyme, modulates substrate protein function and lipid metabolism through enzymatic thioester bond hydrolysis of the palmitoyl-thioester bond. While PPT1 may regulate lipid met...
ABHD6 suppression attenuates pro-inflammatory responses in mice and promotes anti-inflammatory polarization of macrophages during endotoxin stress [0.03%]
ABHD6抑制可减轻小鼠内毒素应激下的促炎反应并促进巨噬细胞向抗炎表型极化
P Poursharifi,C Schmitt,I Chenier et al.
P Poursharifi et al.
α/β-hydrolase domain-containing-6 (ABHD6) hydrolyzes various lipids, including monoacylglycerols (MAGs). Pharmacological inhibition of ABHD6 with WWL70 is anti-inflammatory in animal models. However, because of the multiple substrates of ...
Physiological role of plasmalogen homeostasis in the liver - A link to cholesterol metabolism [0.03%]
肝脏磷脂类稳态的生理作用——与胆固醇代谢的关系
Masanori Honsho,Fabian Dorninger,Johannes Berger et al.
Masanori Honsho et al.
In mammals, plasmalogens are enriched in the brain, kidney, and heart, while the lowest amounts of plasmalogens are found in the liver. The physiological significance of the low level of plasmalogens in the liver remains unknown. Here, we u...
Integrated proteomic and metabolomic analysis reveals lipid metabolic dysregulation and ferroptosis as potential drivers of placental dysfunction in intrahepatic cholestasis of pregnancy [0.03%]
整合蛋白质组学和代谢组学分析揭示了妊娠期肝内胆汁淤积胎盘功能障碍的潜在驱动因素为脂质代谢调节异常和铁死亡
Ruirui Dong,Gaoying Wang,Yingxian Shi et al.
Ruirui Dong et al.
Intrahepatic cholestasis of pregnancy (ICP) is associated with adverse fetal outcomes, while current biomarkers such as total bile acid remain suboptimal. This study aimed to identify novel biomarkers and clarify metabolic pathways underlyi...
John Z Chan,Michelle V Tomczewski,Antonia N Berdeklis et al.
John Z Chan et al.
Barth Syndrome (BTHS) is an ultra-rare, X-linked mitochondrial disorder caused by a variety of different mutations in the cardiolipin remodeling gene TAFAZZIN that results in cardiac and skeletal myopathy, as well as immunological deficits....
ApoB: The intracellular protein detection dilemma in lipoprotein biology [0.03%]
APOB：细胞内蛋白质检测的困境及脂蛋白生物学中的作用
Ankia Visser,Floris A Feiner,Willemien Heerema-van Zwol et al.
Ankia Visser et al.
Hypertriglyceridemia impairs HDL functionality, promotes macrophage metabolic activation and exacerbates antigen-induced rheumatoid arthritis in mice which can be reversed by fenofibrate treatment [0.03%]
高甘油三酯血症损害HDL功能，促进巨噬细胞代谢活化并加剧抗原诱导的小鼠类风湿性关节炎且苯扎贝特处理可逆转上述作用
Isidoros Axiotis,Asimina Kakale,Despina Lazaridou et al.
Isidoros Axiotis et al.
Rheumatoid arthritis (RA) is associated with increased cardiovascular disease (CVD) risk, partly attributed to altered lipid metabolism. Apolipoprotein C-III (ApoC-III), a key regulator of triglyceride-rich lipoproteins in the plasma, has b...
Pulmonary surfactant protein SP-C regulates lipid vesicle uptake by alveolar type II cells and macrophages: Role of lipids, palmitoylation, and environment [0.03%]
肺表面活性物质蛋白SP-C通过脂质、棕榈酰化和环境调节肺泡II型细胞及巨噬细胞的脂质囊泡内吞作用及其机制研究
Mishelle Morán-Lalangui,Marta Villoslada-González,Carmen Hevia-Lorenzo et al.
Mishelle Morán-Lalangui et al.
Pulmonary surfactant protein C (SP-C) may play a key role in alveolar homeostasis by modulating vesicle uptake in alveolar cells. This study explores how SP-C regulates internalization of model unilamellar lipid vesicles by type II alveolar...
Age-related changes in cardiolipin profile and functional consequences of altered fatty acid supply [0.03%]
与年龄相关的线粒体四烯酸卡尼汀水平下降及脂肪酸组成变化导致的心肌收缩功能受损
Philipp W Weiß,Philip P Kaltenborn,Christiane Frahm et al.
Philipp W Weiß et al.
Cardiolipins (CLs) are primarily expressed in the inner mitochondrial membrane where they play essential roles in membrane architecture and mitochondrial functions. CLs have a unique structure characterized by four acyl chains with differen...
Molecular basis for regulation of the class I phosphoinositide 3-kinases (PI3Ks), and their targeting in human disease [0.03%]
调控I类磷脂酰肌醇3-激酶（PI3K）的分子机制及其在人类疾病中的靶向作用
Alexandria L Shaw,Isobel Barlow-Busch,John E Burke
Alexandria L Shaw
The class I phosphoinositide 3-kinase pathway (PI3K) is a master regulator of cellular growth, and plays essential roles in controlling immune cell function, metabolism, chemotaxis and proliferation. Activation of class I PI3Ks generates th...