Reduced cholesterol alters the biophysical properties of repaired myelin [0.03%]
胆固醇降低可改变修复髓鞘的生物物理特性
Estephanie L Nottar Escobar,Nishama De Silva Mohotti,Mara Manolescu et al.
Estephanie L Nottar Escobar et al.
The myelin sheath is a lipid-rich membrane that ensheathes axons and is required for healthy and efficient signal transduction. Myelin is damaged in neurological diseases like multiple sclerosis, but remyelination can occur through the acti...
Rapamycin induced autophagy enhances lipid breakdown and ameliorates lipotoxicity in Atlantic salmon cells [0.03%]
雷帕霉素诱导的自噬能增强大西洋鲑鱼细胞脂质分解并缓解脂毒性
Kanchan Phadwal,Jennifer Haggarty,Dominic Kurian et al.
Kanchan Phadwal et al.
Autophagy is a highly conserved cellular recycling process essential for homeostasis in all eukaryotic cells. Lipid accumulation and its regulation by autophagy are key areas of research for understanding metabolic disorders in human and mo...
Lauric acid ameliorates excessive linoleic acid induced macrophage inflammatory response and oxidative stress in large yellow croaker (Larimichthys crocea) [0.03%]
月桂酸缓解卵磷脂过量诱导大黄鱼巨噬细胞炎症反应和氧化应激损伤
Yuhang Tang,Yanan Shen,Wencong Lai et al.
Yuhang Tang et al.
Macrophages are particularly prone to inflammation and oxidative stress upon exogenous stimulus. Previous investigations have shown that lauric acid (LRA) exerts anti-inflammatory and antioxidant effects, however, the molecular mechanism re...
DHA suppresses hormone-sensitive and castration-resistant prostate cancer growth by decreasing de novo lipogenesis [0.03%]
二十二碳六烯酸通过减少从头生成脂类合成抑制雄激素敏感性和去势抵抗性前列腺癌生长
G H Tamarindo,C F Ribeiro,S Rodrigues et al.
G H Tamarindo et al.
Objective: De novo lipogenesis (DNL) is associated with prostate cancer (PCa) progression, while fatty acid synthase (FASN) overexpression is a hallmark of DNL. Palmitate, its main product, is a saturated fatty acid that ...
Alterations of asparagus (Asparagus officinalis L.) divinyl ether synthase (CYP74H2) catalysis by site-directed mutagenesis [0.03%]
定点突变改变芦笋(CYP74H2)分歧醇合酶催化的反应性质
Svetlana S Gorina,Natalia V Lantsova,Yana Y Toporkova et al.
Svetlana S Gorina et al.
Divinyl ether synthases (DESs) are the enzymes catalyzing the dehydration of fatty acid hydroperoxides to divinyl ether oxylipins. DESs, along with allene oxide synthases (AOSs), hydroperoxide lyases (HPLs), and epoxyalcohol synthases (EASs...
Targeted lipidomic reveals dietary LA/n-3 PUFAs regulate inflammation and redox status via oxylipins in bivalves [0.03%]
靶向脂质组学揭示饮食中的LA/n-3 PUFA通过双壳类动物的环氧二十烷来调节炎症和氧化状态
Yuxiang Zhu,Kai Liao,Yang Liu et al.
Yuxiang Zhu et al.
Oxylipins are bioactive lipid mediators derived from fatty acids; however, a comprehensive investigation of oxylipin profiles is absent in bivalves. Moreover, the physiological functions and bioactivities of PUFA-derived oxylipins warrant f...
Adiponectin receptor agonist AdipoRon regulates glucose and lipid metabolism via PPARγ signaling pathway in hepatocytes of large yellow croaker (Larimichthys crocea) [0.03%]
脂肪细胞素受体激动剂AdipoRon通过PPARγ信号通路调节大黄鱼肝细胞糖脂代谢
Xiang Xu,Xiao Tang,Renlei Ji et al.
Xiang Xu et al.
Activation of adiponectin receptors (AdipoRs) has been shown to regulate glucose and lipid metabolism in mammalian hepatocytes. However, much less is known for their roles in fish. The current study demonstrated that AdipoRon, a small-molec...
The effect of perinatal supplementation of DHA on specialized pro-resolving lipid mediators in the brain of offspring [0.03%]
围产期DHA补充对后代脑组织中特异性促-resolution脂质介质的影响
Stephanie Dubrof,Jillien G Zukaitis,Ishfaque Ahmed et al.
Stephanie Dubrof et al.
The perinatal period is crucial for fetal neurological development, relying on omega-3 polyunsaturated fatty acids (PUFAs) for essential processes. Omega-3 PUFA, including docosahexaenoic acid (DHA), are precursors to a novel class of bioac...
Oroxylin A ameliorates non-alcoholic fatty liver disease by modulating oxidative stress and ferroptosis through the Nrf2 pathway [0.03%]
黄芩素A通过Nrf2途径调节氧化应激和铁死亡从而改善非酒精性脂肪肝病
Yuzi Jiang,Kangwei Jiang,Peilin Sun et al.
Yuzi Jiang et al.
Non-alcoholic fatty liver disease (NAFLD) is a prevalent and progressive liver disorder posing a global health challenge. Oroxylin A, a naturally occurring flavonoid, with a broad spectrum of pharmacological activities. This study aimed to ...
Fatty acid desaturases in non-photosynthetic bacteria: classification, regulation, and roles in plasma membrane function and cellular homeostasis [0.03%]
化脓性细菌中的脂肪酸去饱和酶：分类、调节及其在质膜功能和细胞稳态中的作用
Ye Tao,Yilin Sun,Yidan Chai et al.
Ye Tao et al.
Fatty acid desaturases are key enzymes that catalyze the desaturation of acyl lipid chains by regioselectively introducing double bonds into saturated or pre-existing alkene fatty acids to produce unsaturated fatty acids. While extensive st...