Molecular basis for regulation of the class I phosphoinositide 3-kinases (PI3Ks), and their targeting in human disease
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The class I phosphoinositide 3-kinase pathway (PI3K) is a master regulator of cellular growth, and plays essential roles in controlling immune cell function, metabolism, chemotaxis and proliferation. Activation of class I PI3Ks generates the signalling lipid P... ...
