Intestinal stearoyl-CoA desaturase-2 is highly expressed and nutritionally regulated but dispensable for energy balance [0.03%]
肠棕榈酰辅酶A脱氢酶-2高度表达且受营养调节，但不参与能量平衡
Matthew Selby,Camille Duchamp,Natalie Burchat et al.
Matthew Selby et al.
The stearoyl-CoA desaturase (SCD) enzymes convert saturated fatty acids to monounsaturated fatty acids (MUFAs). Deletion of intestinal SCD1 confers metabolic benefits upon high-fat diet (HFD) feeding. We report here that mice express a seco...
Lipid cargo of exosomes derived from pancreatic stellate cells and cancer cells: Role in pancreatic cancer-related diabetes [0.03%]
胰腺星状细胞和癌细胞来源的外泌体脂质负荷：在胰腺癌相关糖尿病中的作用
Rohit Sarkar,Patrick Wu,Helen Binang et al.
Rohit Sarkar et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy often accompanied by pancreatic cancer related diabetes (PCRD), a paraneoplastic condition characterised by early metabolic dysfunction. Emerging evidence suggests that f...
Single-cell RNA and ATAC sequencing reveals cell subsets characteristics in adipose-derived stem cells [0.03%]
单细胞RNA和ATAC测序揭示脂肪来源干细胞亚群特征
Qingxi Long,Yi Yuan,Zhenjiang Liu et al.
Qingxi Long et al.
The inherent heterogeneity of adipose-derived stem cells (ADSCs) complicates their characterization, as aggregated data obscure the nuanced states of individual cells and are skewed by dominant functional subpopulations affecting genetic an...
Cadmium-induced ATP6V0A1 destabilization impairs lysosomal function to disrupt hepatic lipid homeostasis [0.03%]
镉通过诱导ATP6V0A1解聚来干扰溶酶体功能并破坏肝脏脂质稳态
Juan Huo,Kongdong Li,Haifeng Shi et al.
Juan Huo et al.
Chronic cadmium (Cd2+) exposure is epidemiologically linked to metabolic disorders like hypertriglyceridemia, but the precise mechanisms disrupting hepatic lipid metabolism are unclear. Lysosomal function, critical for lipid degradation via...
FTO mediates m6A demethylation of HNF1A and drives hepatic steatosis in metabolic dysfunction-associated steatotic liver disease [0.03%]
FTO介导的HNF1A去N6-甲基腺苷修饰在代谢功能异常相关性脂肪肝病发病中的作用机制研究
Jiaorong Tan,Chao Shi,Guangyu Wang et al.
Jiaorong Tan et al.
Objective: Despite advances in understanding metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis, effective therapeutic targets remain limited. This study aimed to identify novel regulatory mecha...
Surfactant nebulization in severe COVID-19: Tracheal aspirate phospholipid turnover and metabolism [0.03%]
新冠肺炎重症患者表面活性物质雾化治疗：气管吸引物中磷脂周转及代谢情况
Anthony D Postle,Howard W Clark,James Fink et al.
Anthony D Postle et al.
COV-SARS-2 targets alveolar type II cells. As these cells synthesise lung surfactant, we hypothesised that surfactant dysfunction may contribute to development of ARDS in COVID-19. Here we report turnover of surfactant delivered to patients...
Targeting peroxisomal fatty acid β-oxidation lowers fasting glucose by suppressing gluconeogenesis [0.03%]
靶向过氧化物酶体脂肪酸β氧化通过抑制糖异生降低空腹血糖水平
Wei Zhang,Yicong Li,Yida Zhang et al.
Wei Zhang et al.
Fatty acids play an important role in regulating gluconeogenesis through the metabolite acetyl-CoA, however, the underlying mechanisms on how fatty acid oxidation provides acetyl-CoA for the stimulation of pyruvate carboxylase and gluconeog...
Palmitoylated STX11 suppresses AMPK to drive lipogenesis and colorectal cancer [0.03%]
棕榈酰化STX11通过抑制AMPK促进脂质合成和结直肠癌发展
Bao Li,Zhongkang Yan,Wenyuan Dang et al.
Bao Li et al.
Syntaxin 11(STX11), a SNARE family protein, regulates vesicular trafficking and cytokinesis, yet its functional role in colorectal cancer (CRC) pathogenesis remains poorly understood. Here, we identify STX11 as a critical regulator that pot...
Palmitic acid and myristic acid promote myogenesis through dual effects on myoblast cell cycle exit and myotube formation [0.03%]
棕榈酸和肉豆蔻酸通过影响肌管形成及肌前体细胞退出细胞周期促进骨骼肌分化
Ruifang Guo,Yining Zhang,Panpan Liu et al.
Ruifang Guo et al.
Myogenic differentiation plays a vital role in embryonic muscle formation, postnatal muscle regeneration and repair processes. Exogenous fatty acids (FAs) influence physiological functions of skeletal muscle. Nevertheless, our grasp of how ...
Palmitoylation of C4BPA in porcine epididymosomes mitigates complement C4-mediated damage to sperm [0.03%]
棕榈酰化修饰的C4BPA在猪附睾小泡中可缓解补体C4介导的精子损伤
Heran Cao,Long Li,Shujuan Liu et al.
Heran Cao et al.
Previous studies have revealed the expression of anti-complement factors on the surface of sperm across various species to resist attacks from complement components in reproductive tracts. Here we show that the anti-complement factor The ca...