Galectin-3 gene deletion alters lipid profile in healthy and cardiomyopathy mouse hearts [0.03%]
半乳糖凝集素-3基因缺失可改变健康及心肌病小鼠心脏脂质谱特征
Xiao-Jun Du,Kevin Huynh,Mark Ziemann et al.
Xiao-Jun Du et al.
Galectin-3 (Gal3) is known to interact with glycans of proteins and lipids. In cardiovascular disease, the elevated expression of Gal3 mediates inflammation, hypertrophy and fibrosis. We explored the effect of Gal3 on the cardiac lipid prof...
The influence of soluble epoxide hydrolase inhibition and their PUFA-derived epoxides in osteoblast bone metabolism: an in vitro study [0.03%]
可溶性环氧合酶抑制剂及其多不饱和脂肪酸衍生物对成骨细胞骨代谢影响的体外实验研究
Duilio Benicio E Silva-Junior,Ney Robson Bezerra Ribeiro,David Martins Nunes Junior et al.
Duilio Benicio E Silva-Junior et al.
EpFAs are crucial mediators in resolving inflammation and regulating various biological processes. However, their activity is constrained by the rapid metabolism mediated by the soluble epoxide hydrolase (sEH), which converts EpFAs into ina...
Recombinant hirudin prevents against nonalcoholic fatty liver disease by modulating PAR1/JAK2/STAT5/STAT3/CD36 pathway [0.03%]
重组水蛭素通过调节PAR1/JAK2/STAT5/STAT3/CD36信号通路预防非酒精性脂肪肝病
Y U Xiaoyu,Yi Sun,Changyuan Wang et al.
Y U Xiaoyu et al.
Background: Non-alcoholic fatty liver disease (NAFLD) has become a common liver disease. Recombinant hirudin (R-Hirudin) is an manufactured product produced by genetic engineering technology which possesses antithrombotic...
The individual isoforms of ORMDL, the regulatory subunit of serine palmitoyltransferase, have distinctive sensitivities to ceramide [0.03%]
ORMDL的各个同种型（丝氨酸棕榈酰转移酶调控亚基）对鞘氨醇具有特异敏感性
Usha Mahawar,Deanna L Davis,Muthukumar Kannan et al.
Usha Mahawar et al.
Sphingolipids play crucial roles in cell membrane structure and in multiple signaling pathways. Sphingolipid de novo biosynthesis is mediated by the serine palmitoyltransferase (SPT) enzyme complex. Homeostatic regulation of this complex is...
Androgen regulates seasonal changes in triglyceride synthesis through the AR-SREBP1-FASN axis in the scented glands of muskrats (Ondatra zibethicus) [0.03%]
雄激素通过AR-SREBP1-FASN轴调节麝鼠（Ondatra zibethicus）香腺内三酰甘油合成的季节性变化
Xinjing Shi,Qingjing Gao,Wenjing Lu et al.
Xinjing Shi et al.
SREBP1 (sterol regulatory element binding protein 1) plays an important role in maintaining lipid balance in mammals. Previous research showed that androgen significantly regulated the secretion of lipid-rich musky odor substances from the ...
Endogenous synthesis of n-3 PUFAs can reduce lipid synthesis in Fad3 transgenic cattle [0.03%]
内源合成n-3 PUFA可降低转基因fad3牛的脂质合成
Danyi Li,Yuxin Gao,Xiaoyu Zhao et al.
Danyi Li et al.
n-3 polyunsaturated fatty acids (PUFAs) play important roles in the health, development and growth of mammals. However, most mammals, including humans, cannot synthesize n-6 and n-3 PUFAs and can only obtain them from the diet. The fatty ac...
Acetyl-CoA acyltransferase 2 as a metabolic modulator: Unraveling its impact on hepatic lipid dynamics in chicken embryos [0.03%]
乙酰辅酶a酰基转移酶2作为代谢调节因子：其对鸡胚胎肝脂代谢的影响研究
Mengling Peng,Luyao Kan,Xinyu Zhao et al.
Mengling Peng et al.
Despite the established role of acetyl-CoA acyltransferase 2 (ACAA2) in hepatic lipid homeostasis in mammals, its function in regulating hepatic lipid metabolism during the embryonic stage of chickens remains unexplored. This study aimed to...
Different effects of Lorenzo's oil components against very long-chain fatty acid-induced endoplasmic reticulum stress in peroxisome-deficient CHO cells [0.03%]
橄榄油成分对抗极长链脂肪酸诱导的过氧化物酶体缺陷CHO细胞内质网应激的不同的效应
Hanif Ali,Mone Yamanishi,Rumana Yesmin Hasi et al.
Hanif Ali et al.
Adrenoleukodystrophy (ALD) is an X-linked peroxisomal disorder caused by mutations in the ABCD1 gene, leading to the accumulation of very long-chain fatty acids (VLCFAs). The accumulation of saturated VLCFAs, such as C24:0 and C26:0, is bel...
Håvard S Haukaas,Harald Stenmark
Håvard S Haukaas
Membrane contact sites (MCSs) between the different compartments of the cell play important roles in lipid, protein and ion transfer. Phosphoinositides are crucial for the functions of many MCSs, either as membrane anchors for MCS proteins,...
Mateusz Kondratowicz,Ambroise Wu,Ewa Grela et al.
Mateusz Kondratowicz et al.
The plasma membrane, composed mostly of lipids and proteins, is a dynamic structure essential for maintaining cellular homeostasis and signaling. Its composition, organization and molecular dynamics have important functional consequences fo...