Gallic acid attenuates LPS-induced hepatic injury via SIRT-1-dependent immunomodulation and anti-apoptotic mechanisms in rats [0.03%]
没食子酸通过SIRT-1依赖的免疫调节和抗凋亡机制缓解脂多糖诱导的大鼠肝损伤
Ahmet Bindal,Halil Aşçı,Pınar Karabacak et al.
Ahmet Bindal et al.
Sepsis-related hepatic injury arises from intertwined inflammatory, oxidative, and apoptotic mechanisms. This study aimed to evaluate the hepatoprotective effects of gallic acid (GA), a natural polyphenol, in a lipopolysaccharide (LPS)-indu...
miR-3099-5p alters cellular lipid levels and induces mitochondrial dysfunction by targeting FACL4 in mouse hepatic cells [0.03%]
miR-3099-5p通过靶向FACL4改变细胞脂质水平并诱导线粒体功能障碍小鼠肝细胞中发生的事件
Shalu Rathore,Ashima Rizvi,Radhika Kansal et al.
Shalu Rathore et al.
Aberrant endoplasmic reticulum (ER) and mitochondria function mediated by deregulated levels of tethering proteins at the mitochondria-associated ER membranes (MAM) sites is a hallmark of several diseases, yet very little is known of the re...
ADARB1 inhibits glycolysis and progression of cervical cancer through the HMGB1/PFKFB3 axis [0.03%]
ADARB1通过HMGB1/PFKFB3轴抑制宫颈癌的糖酵解和进展
Xuelian Liu,Anjin Wang,Min Su et al.
Xuelian Liu et al.
Cervical cancer (CC) remains one of the most prevalent gynecological malignancies worldwide, with patients diagnosed at advanced stages often facing poor prognoses due to the lack of effective therapeutic options. ADARB1 (Adenosine Deaminas...
Urinary microbiome and metabolomic profiling reveal propionic acid as an enhancer of BCG immunotherapy in bladder cancer [0.03%]
基于泌尿系统微生物组和代谢组的分析发现丙酸可增强膀胱癌中BCG免疫治疗的作用
Jing Liu,Yizhao Luo,Lu Chen et al.
Jing Liu et al.
Bladder cancer (BC) is the tenth most common malignancy worldwide, with non-muscle invasive bladder cancer (NMIBC) accounting for approximately 75% of cases, and Bacillus Calmette-Guérin (BCG) remaining the standard intravesical therapy. I...
Mesenchymal stem cells derived from human bone marrow ameliorate monosodium urate crystal-induced inflammation [0.03%]
人骨髓来源的间充质干细胞改善尿酸盐晶体诱导的炎症反应
Ahyoung Choi,Narae Park,Hyerin Jung et al.
Ahyoung Choi et al.
Mesenchymal stem cells (MSCs) have anti-inflammatory properties and have been implicated in several inflammatory diseases. Acute gout is initiated by IL-1β produced by monosodium urate crystal (MSU)-stimulated macrophages via activation of...
Corrigendum to "Nuclear receptor coactivator 4 linked to follicular dysplasia in polycystic ovary syndrome: A key regulator that aggravates ovarian granulosa cells ferritinophagy and ferroptosis" [Biochim Biophys Acta Mol Basis Dis. 1871 (7) (Oct 2025) 167955 (BBADIS 167955)] [0.03%]
关于“核受体辅活化剂4与多囊卵巢综合征滤泡异常相关：一个关键调节因子，加剧卵巢颗粒细胞铁死亡”的勘误[BBA-分子病理机制疾病卷1871期(2025年10月)167955页]
Dejian Chen,Yu Wang,Xiaomin Wang et al.
Dejian Chen et al.
Exploring the intersection of Alzheimer's disease and comorbidities: a review of the interplay between multiple chronic conditions [0.03%]
阿尔茨海默病及其合并症的交汇点：多发慢性疾病的相互作用综述
Sumaiya Khan,Ali Imam,Sunidhi Singh et al.
Sumaiya Khan et al.
Alzheimer's disease (AD) represents degenerative brain disorder that impairs both cognitive functions and daily living activities gradually. It is frequently linked with other disorders such as psychosis, cardiovascular disorders, diabetes,...
Novel VARS1 variants define new clinical and molecular subtypes of a rare neurodevelopmental syndrome [0.03%]
VARS1新突变定义了罕见神经发育障碍的新临床和分子亚型
Busra Aynekin,Tracy Lau,Rauan Kaiyrzhanov et al.
Busra Aynekin et al.
Purpose: We aimed to broaden the understanding of autosomal recessive neurodevelopmental disorders caused by VARS1 by describing new clinical and molecular findings and assessing the predicted structural impact of identif...
RTN4IP1 drives breast tumorigenesis: Molecular mechanisms linking elevated expression to enhanced proliferation, suppressed apoptosis, and therapeutic resistance [0.03%]
RTN4IP1驱动乳腺肿瘤发生：连接表达升高与增殖增强、凋亡抑制和治疗抵抗的分子机制
Weijie He,Yiling Jiang,Baohong Jiang et al.
Weijie He et al.
Abnormal expression of RTN4IP1 is implicated in diverse pathologies, including malignant tumors, yet its role in breast cancer (BC) remains insufficiently defined. This study integrated TCGA-based bioinformatics analysis with experimental v...
NADPH oxidase 5 promotes adhesion and infiltration of immune cells in the brain. Implications in ischemic stroke [0.03%]
NADPH氧化酶5促进免疫细胞在脑内的黏附和浸润及其缺血性卒中后的意义
Javier Marqués,Leyre Basurco,Elena Ainzúa et al.
Javier Marqués et al.
Blood-brain barrier (BBB) disruption and immune cell infiltration increase the pathological outcomes present in aging, neurodegenerative diseases, and stroke. NADPH oxidase 5 (NOX5) is a ROS-producing enzyme that promotes BBB-permeability i...