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Prophylactic systemic low-dose pirfenidone attenuates intrauterine adhesion by inhibiting the TGF-β1/Smad3 pathway

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Background: Intrauterine adhesion (IUA) is a severe fibrotic disorder lacking effective non-surgical treatments. This study explored pirfenidone (PFD), an antifibrotic drug approved for treating lung fibrosis, as a potential ther... ...