Yuchen Yang,Tjasso Blokzijl,Antonio Miguel da Costa de Pina et al.
Yuchen Yang et al.
Background & aims: Goblet cells produce mucus protecting the intestinal epithelium. Depleted goblet cells and a disrupted mucus layer are observed in inflammatory bowel diseases (IBD). Remarkably, both deficiency and over...
Microglial GLUL loss worsens TBI outcomes by amplifying the arginine-citrulline pathway [0.03%]
微胶质细胞GLUL丢失通过放大精氨酸-瓜氨酸途径恶化脑损伤预后
Jianwei Li,Yuanlin Zhao,Yang Yang et al.
Jianwei Li et al.
Microglial hyperactivation-induced neuroinflammation is a central driver of neurological dysfunction after traumatic brain injury (TBI). Metabolic reprogramming is essential for microglial activation, but the specific metabolic alterations ...
Genetic alterations in SUPT6H are associated with neurodevelopmental disorders [0.03%]
SUPT6H基因的遗传改变与神经发育障碍相关
Bruno Carabelli,Hyung-Goo Kim,Bonsu Ku et al.
Bruno Carabelli et al.
Genetic variants affecting the RNA polymerase II complex have been associated with various neurodevelopmental disorders (NDDs). SUPT6H, an RNA polymerase II-associated elongation factor and a histone chaperone, plays a critical role in tran...
ELK1/NOL3/GRP78 axis regulates proliferation and stemness in TP53-mutant colon cancer by enhancing adaptive endoplasmic reticulum stress [0.03%]
ELK1/NOL3/GRP78轴通过增强适应性内质网应激调节TP53突变型结直肠癌细胞的增殖和干性
Lifen Zhang,Yang Gao,Jingjing Xu et al.
Lifen Zhang et al.
Background: Colon cancer harboring TP53 mutations is highly aggressive and associated with short survival. Adaptive, rather than apoptotic, endoplasmic reticulum (ER) stress endows TP53-mutant tumor cells with enhanced pr...
Xiaoli Zheng,Jing Cheng,Manman Zhang et al.
Xiaoli Zheng et al.
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer and is characterized by high metastatic propensity and poor clinical outcomes. Elucidating the molecular mechanisms underlying ccRCC progression is therefor...
Hepatocyte specific Rab27a knockout aggravates metabolic dysfunction associated fatty liver disease [0.03%]
肝细胞特异性Rab27a基因敲除加重代谢紊乱相关性脂肪肝病
Jia-Ying Hu,Xin-Yi Liao,Rong-Zheng Ran et al.
Jia-Ying Hu et al.
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a leading cause of chronic liver morbidity, yet its molecular pathogenesis remains incompletely elucidated. Exosomes, a distinct class of extrace...
Probiotic Lactobacillus rhamnosus mitigates PBC-like features in Mcpip1-deficient mice via modulation of gut-liver crosstalk [0.03%]
鼠李糖乳杆菌通过调节肠道-肝脏交叉对话缓解Mcpi缺乏小鼠的自身免疫性胆汁淤积特征
Katarzyna Trzos,Tomasz Hutsch,Anastasiia Koval et al.
Katarzyna Trzos et al.
Background: Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by progressive biliary destruction and cholestasis. Current therapies, including ursodeoxycholic acid (UDCA), exhibit limit...
ACE2 acts as a tumor suppressor in breast cancer by inhibiting progression via the TGF-β1/Smad pathway and potentiating immune checkpoint blockade [0.03%]
ACE2通过抑制TGF-β1/Smad通路介导的进程并增强免疫检查点阻断在乳腺癌中起抑癌作用
Jianya Cai,Feijing Wu,Ying Wang et al.
Jianya Cai et al.
Angiotensin-converting enzyme 2 (ACE2) is acknowledged for its crucial function as a receptor in pneumonia. However, emerging evidence suggests that ACE2 also plays a significant role in tumor progression, but its regulatory mechanisms in b...
A control theoretical approach to gene regulation reveals quantitative constraints for dynamic homeostasis in stochastic gene expression [0.03%]
基于控制理论的基因调控研究揭示了随机基因表达中动态稳态的定量约束条件
Guilherme Giovanini,Cyro von Zuben de Valega Negrão,Ammar Alsinai et al.
Guilherme Giovanini et al.
Cell phenotype dynamic homeostasis contrasts with the inherent randomness of intracellular reactions. Although feedback control of regulator genes (RG) is a key strategy for limiting the range of downstream gene expression, understanding th...
Corrigendum to "Novel VARS1 variants define new clinical and molecular subtypes of a rare neurodevelopmental syndrome" [Biochim. Biophys. Acta Mol. Basis Dis. 1872 (2026)/168184] [0.03%]
关于“VARS1新变异定义罕见神经发育综合征的新临床和分子亚型”的勘误[BBA-分子疾病机制，卷1872（2026）/168184]
Busra Aynekin,Tracy Lau,Rauan Kaiyrzhanov et al.
Busra Aynekin et al.