Syrosingopine enhances immune checkpoint blockade efficacy by inhibition of MCTs and metabolic reprogramming in triple-negative breast cancer [0.03%]
syrosingopine通过抑制MCTs和代谢重编程增强免疫检查点阻断在三阴性乳腺癌中的疗效
Liu Yang,Cunyu Tang,Xiaorui Cheng et al.
Liu Yang et al.
Immune checkpoint blockade (ICB) provides limited benefit in triple-negative breast cancer (TNBC), partly due to a lactate-rich, immunosuppressive tumor microenvironment (TME). Integrative bulk and single-cell transcriptomics, corroborated ...
Corrigendum to "Orai1 is critical for notch-driven aggressiveness under hypoxic conditions in triple-negative breast cancers" [Biochim Biophys Acta Mol Basis Dis 2018 Apr;1864(4 Pt A):975-986] [0.03%]
“ORAI1是缺氧条件下三阴性乳腺癌NOTCH驱动侵袭性的关键因子”的勘误启事[BBA-分子病生学机制,2018年4月，第1864卷，第4期A，975-986页]
Xiaoyu Liu,Teng Wang,Yan Wang et al.
Xiaoyu Liu et al.
Cepharanthine-mediated PD-L1 autophagic degradation via regulation of TSPO and RILP boosts anti-lung cancer chemo-immunotherapy efficacy [0.03%]
通过调节TSPO和RILP介导的PD-L1自噬降解增强头花蓼碱抗肺癌化疗免疫疗效
Yu-Jie Gao,Si-Yuan Chen,Liu-Gen Li et al.
Yu-Jie Gao et al.
Non-small cell lung cancer (NSCLC) accounts for the second highest incidence and highest mortality rates globally, wherein immune checkpoint molecules such as PD-L1, highly-expressed in malignant cells bind to PD-1 located in immunocytes, l...
Expression of concern for "Carcinogen-induced early molecular events and its implication in the initiation of chemical hepatocarcinogenesis in rats: Chemopreventive role of vanadium on this process' by Malay Chatterjee" [Biochim. Biophys. Acta (BBA) Mol. Basis Dis. 1772 (1) (January 2007) 48-59 https://doi.org/10.1016/j.bbadis [0.03%]
关于《马来·查特吉：论化学致癌剂诱导的早期分子事件及其对大鼠化学性肝细胞癌发生的影响过程中的钒的化学预防作用》一文的表达关注公告
HN1/CEBPB/CCL2 signaling shapes VSIG4+ tumor-associated macrophages in anaplastic thyroid carcinoma [0.03%]
CEBPB/CCL2信号通路塑造anaplastic甲状腺癌中VSIG4+肿瘤相关巨噬细胞
Ziwen Fang,Ying Li,Xiaoping Hu et al.
Ziwen Fang et al.
V-set and immunoglobulin domain-containing protein 4 (VSIG4) positive tumor-associated macrophage (VSIG4+ TAM) is an immunosuppressive subpopulation specifically infiltrates anaplastic thyroid carcinoma (ATC) tissues and drives tumor growth...
EA1-linked Kv1.1 dysfunction enhances susceptibility to cerebellar spreading depression and a transient cerebellar refractory state [0.03%]
EA1相关钾通道Kv1.1功能障碍增强小脑扩散抑制及瞬时小脑不应期的易感性
Ilenio Servettini,Alfredo Megaro,Martino Caramia et al.
Ilenio Servettini et al.
Episodic ataxia type 1 (EA1) is a neurological channelopathy caused by loss-of-function mutations in the KCNA1 gene, which encodes the Kv1.1 α-subunit of voltage-gated potassium channels. Clinically, EA1 is characterized by interictal myok...
GALNT6 coordinates glycolysis and α-KG-dependent DNA methylation to promote TNBC progression [0.03%]
GALNT6通过协调糖酵解和α-KG依赖性DNA甲基化来促进三阴性乳腺癌的进展
Ziming Bian,Yang Liu,Shiqun Guo et al.
Ziming Bian et al.
Background: As the most aggressive form of breast cancer, triple-negative breast cancer (TNBC) is associated with poor prognosis and a lack of effective therapeutic options. Glycosylation has been linked to metabolic repr...
p300/Ahnak1 promotes the depression of ICa,L of atrial myocytes induced by aging [0.03%]
P300/Ahnak1促进衰老大鼠心房肌细胞ICa,L的降低
De-Wei Peng,Qiao-Qiao Li,Hai-Yan Liu et al.
De-Wei Peng et al.
Atrial electrical remodeling induced by aging, characterized by decreased L-type calcium channel current (ICa,L) and shortened action potential duration (APD), contributes to the onset of atrial fibrillation (AF). Our previous study reveale...
MARCHF6 regulates ferroptosis in myocardial ischemia-reperfusion injury via the ADAMTS4/SDC-1 pathway [0.03%]
MARCHF6通过ADAMTS4/SDC-1通路调节心肌缺血再灌注损伤中的铁死亡
Qi Lou,Rui Bai,Yongwu Liu et al.
Qi Lou et al.
Myocardial ischemia-reperfusion injury is a key factor affecting prognosis after acute myocardial infarction. MARCHF6, as an E3 ubiquitin ligase, is closely implicated in the ferroptosis process. The role of MARCHF6 in MIRI and its mechanis...
Pretreatment of ADSCs with resveratrol-functionalized selenium nanoparticles alleviate CCl4-induced liver fibrosis in mice [0.03%]
白藜芦醇硒纳米颗粒预处理的间充质干细胞减轻四氯化碳诱导的小鼠肝纤维化
Shuangjuan Liu,Ziqiang Zhang,Dongliu Luo et al.
Shuangjuan Liu et al.
Background: Liver fibrosis (LF) is an abnormal repair reaction after chronic liver injury. Currently, adipose-derived mesenchymal stem cells (ADSCs) are widely used in the treatment of liver diseases. However, the therape...