Cepharanthine-mediated PD-L1 autophagic degradation via regulation of TSPO and RILP boosts anti-lung cancer chemo-immunotherapy efficacy
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Non-small cell lung cancer (NSCLC) accounts for the second highest incidence and highest mortality rates globally, wherein immune checkpoint molecules such as PD-L1, highly-expressed in malignant cells bind to PD-1 located in immunocytes, leading to immune esc... ...