Baicalein mitigates anti-tuberculosis-induced liver injury via inhibition of lipid peroxidation mediated by ferritinophagy and ferroptosis: Involvement of Yap 1/NCOA4 signaling [0.03%]
黄芩素通过抑制铁死亡介导的脂质过氧化及铁蛋白溶噬缓解抗结核药物引起的肝损伤：Yap 1/NCOA4信号轴参与作用
Yining Liu,Zhenhui Liu,Chenjunlei Luo et al.
Yining Liu et al.
Anti-tuberculosis drug-induced liver injury (ATB-DILI) is a leading cause of impaired anti-TB treatment efficacy in patients with tuberculosis. Baicalein (Bai), a dietary flavonoid from the root of Scutellaria baicalensis, exhibits diverse ...
Cellular prion protein suppresses colitis and colorectal carcinogenesis via modulating inflammatory responses [0.03%]
细胞内原蛋白通过调节炎症反应抑制结肠炎和结直肠癌发生
Tiantian Zhao,Wenyuan Wang,Qingwen Wang et al.
Tiantian Zhao et al.
Reducing prion protein (PrP) levels is a leading therapeutic strategy against prion disease. However, the normal function of PrP remains incompletely understood, creating uncertainty about the potential consequences of this approach. We inv...
CircUBAP2 promotes intrahepatic cholangiocarcinoma progression via PRMT1-p65 methylation and the miR-642b-5p/IL-1β axis [0.03%]
Circular RNA CircUBAP2通过PRMT1-p65甲基化和miR-642b-5p/IL-1β轴促进肝内胆管癌进展
Chang Li,Shuochen Liu,Changan Chen et al.
Chang Li et al.
Intrahepatic cholangiocarcinoma (ICC) frequently exhibits inflammatory signaling and poor outcomes, yet upstream regulators that maintain NF-κB activity remain incompletely defined. Here, we identified circUBAP2 (hsa_circ_0001851) by circR...
ACSS2 promotes macrophage senescence and atherosclerosis by upregulating histone H3 lysine 9 crotonylation [0.03%]
乙酰辅酶A合成酶2通过上调组蛋白H3赖氨酸9丁烯二酸化促进巨噬细胞衰老和动脉粥样硬化
Quanwen Yin,Jie Yang,Yaoyuan Xu et al.
Quanwen Yin et al.
Atherosclerosis (AS) is an aging-related chronic inflammatory disease. Histone lysine crotonylation (Kcr) is a posttranslational modification, which is widespread as acetylation; however, its roles are largely unknown in senescent macrophag...
The tumor-nerve-immune electrical axis: A hypothesis-generating framework for electrochemical communication in cancer [0.03%]
肿瘤-神经-免疫电轴：癌症电化学通讯的假说生成框架
Peng-Yu Zhao,Wei-Lin Jin
Peng-Yu Zhao
The tumor microenvironment (TME) is traditionally studied through biochemical, metabolic, and mechanical lenses. Increasing evidence, however, indicates that ion channels, membrane potential, and local ionic conditions also influence tumor ...
Regular exercise improves cardiac dysfunction in Drosophila by inhibiting excessive mitochondrial fission through RalA [0.03%]
有规律的锻炼通过RalA抑制线粒体过度分裂从而改善果蝇心脏功能
Wenqing Huang,Meng Ding,Qin Yi et al.
Wenqing Huang et al.
Metabolic disorders leading to cardiac dysfunction have become a global health challenge, and the cardioprotective mechanisms of regular exercise remain unclear. This study focused on the small GTPase RalA and revealed its critical role in ...
HSP27 in autoimmune diseases: Context-dependent regulation and clinical potential [0.03%]
热休克蛋白27在自身免疫病中的作用：调控机制与临床应用前景分析
Jianbin Li,Renhe Li,Wenwen Wang et al.
Jianbin Li et al.
Background: Heat shock protein 27 (HSP27) is a crucial member of the small heat shock protein family with a molecular weight of approximately 27 kDa, playing key roles in cellular stress response, protein homeostasis, and...
MAPK/c-Jun/TNNT1 pathway regulates cytoskeletal remodeling and promotes tumor invasion and metastasis in HNSCC [0.03%]
MAPK/c-Jun/TNNT1信号通路通过重塑细胞骨架促进头颈鳞癌侵袭转移
Jing Xie,Xiaoqian Lin,Guangyang Chen et al.
Jing Xie et al.
Background: Metastasis in head and neck squamous cell carcinoma (HNSCC) significantly reduces patient survival, but its molecular mechanisms remain incompletely understood. This study aims to investigate the role and regu...
Immunoediting characteristics and immunotherapy strategy optimization in HBV-related hepatocellular carcinoma [0.03%]
乙型肝炎病毒相关肝细胞癌的免疫编辑特征及免疫治疗策略优化
Junchao Zhu,Hui Zhang,Zhiling Wang et al.
Junchao Zhu et al.
Hepatocellular carcinoma (HCC) is a globally prevalent malignant tumor with high mortality, and chronic hepatitis B virus (HBV) infection is its most important risk factor. The occurrence and progression of HBV-related HCC (HBV-HCC) are clo...
ST3GAL1 mediates sialylation to promote adhesion of Fusobacterium nucleatum to colorectal cancer cells [0.03%]
福斯菌通过介导唾液酸化促进与结直肠癌细胞的黏附
Li Xiao,Tao Gong,Wanyi Luo et al.
Li Xiao et al.
Fusobacterium nucleatum is a commensal bacterium in the oral cavity and is closely related to several oral infectious diseases. In addition to oral colonization, F. nucleatum is enriched in colorectal cancer (CRC) and is closely associated ...