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ACSS2 promotes macrophage senescence and atherosclerosis by upregulating histone H3 lysine 9 crotonylation

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Atherosclerosis (AS) is an aging-related chronic inflammatory disease. Histone lysine crotonylation (Kcr) is a posttranslational modification, which is widespread as acetylation; however, its roles are largely unknown in senescent macrophage of atherosclerosis... ...