Mutant-specific dysfunction of RHOBTB2 impairs mitochondrial function and Na+/K+-ATPase levels in a cell model [0.03%]
RHOBTB2突变体特异性功能障碍通过细胞模型损害线粒体功能和Na+/K+-ATP酶水平
Sachiko Miyamoto,Shun-Ichi Yamashita,Hazrat Belal et al.
Sachiko Miyamoto et al.
RHOBTB2 is an atypical Rho GTPase implicated in developmental and epileptic encephalopathy, yet its pathogenic mechanisms remain poorly understood. In this study, we established a cell model in which RHOBTB2 expression was induced by a doxy...
NSUN2 activated by KLF6 can mediate m5C modification of NCOA4 to enhance ferroptosis of OGD/R-induced SH-SY5Y cells in ischemic stroke [0.03%]
KLF6激活的NSUN2可以介导NCOA4的m5C修饰以增强缺血性卒中诱导的OGD/R引起的SH-SY5Y细胞铁死亡
Genshan Gao,Yue Xu,Yao Liu et al.
Genshan Gao et al.
Ischemic stroke (IS) constitutes the majority of stroke cases. Ferroptosis, a non-apoptotic form of programmed cell death, is an essential mechanism of IS. This study aimed to investigate a ferroptosis-related molecular mechanism in IS prog...
The tumor suppressor role of mitochondrial E3 ubiquitin ligase MUL1 in osteosarcoma [0.03%]
线粒体E3泛素连接酶MUL1在骨肉瘤中的抑癌作用
Jacopo Di Gregorio,Sara Terreri,Michela Rossi et al.
Jacopo Di Gregorio et al.
Osteosarcoma is a highly aggressive type of bone cancer with a high rate of metastasis. The molecular mechanisms underlying osteosarcoma metastasis are not yet completely understood, representing an ongoing challenge for therapy. A possible...
Cationic liposome-based silencing of thioredoxin reductase-1 for sensitization of MDA-MB 231 cells to gamma radiation [0.03%]
基于阳离子脂质体的硫氧还蛋白还原酶-1沉默对MDA-MB 231细胞放射增敏作用的影响研究
Sandeep B Shelar,Manideepa Basu,P A Hassan et al.
Sandeep B Shelar et al.
Thioredoxin reductase 1 (TrxRd1) is a widely conserved antioxidant enzyme that maintains cellular redox homeostasis by reducing oxidized thioredoxin 1 (Trx1). Overexpression of TrxRd1 has been directly linked to radioresistance in cancer ce...
Ephrin-A1/EphA2 modulates vascular smooth muscle cell proliferation in vitro, while VSMC-specific ephrin-A1 deletion is not sufficient to alter arteriosclerosis in vivo [0.03%]
Ephrin-A1/EphA2调节血管平滑肌细胞增殖，但特异性删除血管平滑肌细胞中的ephrin-A1并不能改变动脉粥样硬化病理表型
Antje Augstein,Sebastian Porth,Johannes Mierke et al.
Antje Augstein et al.
Atherosclerosis, the leading cause of heart attack and stroke, involves plaque formation driven by various cell types, including endothelial cells, immune cells and vascular smooth muscle cells (VSMCs). VSMCs undergo a phenotypic switch fro...
RelK, a YoeB-like toxin from Mycobacterium tuberculosis displays ribosome independent endonucleolytic activity [0.03%]
来自结核分枝杆菌的类YoeB毒力因子RelK具有非依赖核糖体的脱氧核糖核酸酶活性
Shafinaz Rahman Sarah,Nimisha Sinha,Harsh A Gandhi et al.
Shafinaz Rahman Sarah et al.
Type II toxin-antitoxin (TA) modules are paired genetic elements encoding a toxin protein and an associated antitoxin that neutralizes the toxin under favourable growth conditions. Stress-induced degradation of the antitoxin renders the tox...
Sustained Galiellalactone treatment breaks the metastatic resilience of BRAF-inhibitor-resistant melanoma cells [0.03%]
Galiellalactone持续治疗可破坏BRAF抑制剂耐药黑色素瘤细胞的转移性Persistence
Sujoy Bhowmik,Saumya Ranjan Badajena,Satyajit Laxman Murkute et al.
Sujoy Bhowmik et al.
STAT3 hyperactivation in metastatic and therapy-resistant melanoma drives tumorigenesis and immunotherapy resistance by promoting tumor-stromal interactions, making its inhibition a crucial therapeutic strategy. Interestingly, synthetic STA...
Histone methyltransferase NSD3 orchestrates early erythropoiesis by regulating erythroid progenitor cell differentiation and survival [0.03%]
组蛋白甲基转移酶NSD3通过调节红系祖细胞分化和存活来调控早期促红细胞生成作用
Arunim Shah,Shobhita Katiyar,Chandra Prakash Chaturvedi et al.
Arunim Shah et al.
Histone methyltransferase NSD3 also known KMT3F, is an epigenetic regulator that methylates histone H3 at lysine 36, a mark associated with gene activation. Functionally, NSD3 is crucial for supporting various cellular and developmental pro...
Activation of YBX1 and JAK2/STAT3 pathways by RIOK1 increases lenvatinib resistance in hepatocellular carcinoma cells [0.03%]
RIOK1通过激活YBX1和JAK2/STAT3途径增加肝癌细胞对仑伐替尼的耐药性
Ruirui Cao,Yue Wu,Yawei Li et al.
Ruirui Cao et al.
Hepatocellular carcinoma (HCC) is fatal and does not respond well to classical chemotherapies. This paper investigates the molecular mechanism of RIOK1 on lenvatinib resistance in HCC cells. Differentially expressed genes were identified be...
Osteocyte transition induced by quiescent vascular smooth muscle cells through paracrine signaling is independent of shear stress [0.03%]
静止的血管平滑肌细胞通过旁分泌信号诱导成骨细胞的转变独立于剪切应力的影响
Célio J C Fernandes,Bram C J van der Eerden,Rodrigo A Foganholi Silva et al.
Célio J C Fernandes et al.
We investigated how vascular smooth muscle cells (VSMCs) shape osteolineage fate under mechanosignaling, with emphasis on validating effects in mesenchymal stromal cells (MSCs), a more primitive stage than differentiated osteoblasts. Condit...