Podophyllotoxin induces testicular toxicity via the microbiota-gut-testis axis based on the toxicological evidence chain concept [0.03%]
毒理学证据链概念下的鬼臼毒素通过微生物群-肠-睾丸轴诱导睾丸毒性
Yuanyang Shao,Yu Wang,Yihang Dai et al.
Yuanyang Shao et al.
Podophyllotoxin (PPT), a natural lignan with well-established antitumor efficacy and well-documented ovarian toxicity, was first investigated for its potential testicular toxicity in male Sprague-Dawley rats, following the guidance of the T...
GPR56 regulates the expression of key androgen-target genes via G13-Rho-PKN1 axis and is overexpressed in prostate cancer [0.03%]
GPR56通过G13-Rho-PKN1轴调控关键雄激素靶基因的表达并在前列腺癌中过表达
Versha Dahiya,Mukesh Balyan,Harsh Sharma et al.
Versha Dahiya et al.
Androgens and the androgen receptor (AR) play critical roles in prostate cancer (PCa) development and progression. Consequently, primary treatment strategies target either androgen synthesis or androgen-AR interactions. Although initially e...
Comparison of vitamin D metabolites associated with preterm birth in a cohort of Black pregnant women [0.03%]
一项关于黑人孕妇群体中与早产相关的维生素D代谢物的比较研究
Jennifer Woo,Thomas Guffey,Jenny Hoang et al.
Jennifer Woo et al.
Vitamin D deficiency during pregnancy has been associated with increased risk for preterm birth (PTB). However, it is unclear if total 25-hydroxyvitamin D [25(OH)D], the primary measure of vitamin D status in clinical practice, accurately r...
Estrogen's master switch: NFκB-NLRP3, SIRT1-HMGB1, and TLR4 triad tamed for brain rescue in ageing and neurodegeneration [0.03%]
雌激素“总开关”：NFκB-NLRP3、SIRT1-HMGB1和TLR4三联体在衰老和神经变性中的脑保护作用被抑制
Ambika Shandilya,Chander Kant Giri,Dube Aakash Arwind et al.
Ambika Shandilya et al.
Estrogen operates as a pleiotropic steroidal, neuroendocrine modulator to combat accelerated brain ageing and neurodegeneration by addressing a convergent inflammatory-metabolic trio. Estrogen receptor-dependent neural cellular signalling r...
Steroidogenic enzyme dysregulation in polycystic ovary syndrome: Mechanistic insights and emerging therapeutic strategies [0.03%]
多囊卵巢综合征的类固醇生成酶失调：机制见解和新兴治疗策略
Thirumurugan Ayyadurai,Sasikumar Ravi,Aravinth Annamalai
Thirumurugan Ayyadurai
Polycystic ovary syndrome (PCOS) is the most prevalent endocrine-metabolic disorder in women of reproductive age, and is characterized by hyperandrogenism, anovulation, and polycystic ovarian morphology. Emerging molecular evidence has iden...
"Cytochrome P450-Mediated Vitamin D and Cholesterol Metabolism in the Pathophysiology of Neurodevelopmental Disorders" [0.03%]
细胞色素P450介导的维生素D和胆固醇代谢在神经发育障碍病理生理学中的作用
Balachandar Vellingiri,Masako Kinoshita,Ajay Elangovan et al.
Balachandar Vellingiri et al.
Cytochrome P450 (CYP450) enzymes play critical roles in the pathophysiology of neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD), Rett syndrome (RTT), and attention-deficit/hyperactivity disorder (ADHD). Although...
Gallic acid from Moutan Cortex promotes osteoblast differentiation and alleviates osteoporosis in mice by targeting HRAS and activating the ERK pathway [0.03%]
丹皮没食子酸通过靶向HRAS和激活ERK通路促进成骨细胞分化并缓解小鼠骨质疏松症
Weiwei Gu,Haiyan Zhou,Yongjin Sun et al.
Weiwei Gu et al.
Fracture healing is a complex process where osteoblasts appear as central players in restoring bone integrity through proliferation, differentiation, and mineralization. Previous studies have identified several compounds in cortex moutan, w...
Exemestane chronic exposure induces cardiotoxicity by disrupting calcium homeostasis and endothelin pathway: Evidence from biochemical, radiological and histopathological analyses [0.03%]
来那替尼慢性暴露通过干扰钙稳态和内皮素途径诱导心脏毒性：生化、放射学和组织病理学分析证据
Reem Nasser Alotaibi,Muhammad Faisal Hayat,Salim Jamil et al.
Reem Nasser Alotaibi et al.
Exemestane (EMT) is a third-generation steroidal aromatase inhibitor extensively used in hormone receptor (HR)-positive breast cancer therapy and has been known to exert cardiovascular effects during prolonged treatment. The current study w...
Gene-level variability, pathway-level convergence: A systems view of vitamin D signaling [0.03%]
基因水平的变异性和通路水平的一致性：维生素D信号转导的系统分析观点
Ana Paula Irazoqui,Claudia G Buitrago
Ana Paula Irazoqui
Vitamin D signaling produces context-dependent transcriptional responses, but how gene-level variability relates to recurrent pathway-level programs across perturbational models remains incompletely defined. To systematically characterize t...
Smith-Lemli-Opitz syndrome: From cholesterol deficiency to sterol-dependent signaling dysregulation [0.03%]
史密斯-莱米-奥普茨综合征：从胆固醇缺乏到固醇介导的信号调节障碍
Elvira Akhmetzyanova,Albert Rizvanov,Yana Mukhamedshina
Elvira Akhmetzyanova
Smith-Lemli-Opitz syndrome (SLOS) has long been considered a disorder whose primary pathogenic mechanism is cholesterol deficiency. However, accumulating evidence on the effects of the buildup of the cholesterol biosynthesis intermediate 7...