Exploring the Putative Role of EGFR in Prostate Cancer: Interactions with Androgen and Estrogen Receptors [0.03%]
探索EGFR在前列腺癌中的作用：与雄激素受体和雌激素受体的相互作用
G M Gonçalves,D S Souza,Crm Costa et al.
G M Gonçalves et al.
The epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor that plays a critical role in regulating cell proliferation, survival, and differentiation. Aberrant activation or overexpression of EGFR has been obser...
Development of steroidal molecules for targeted breast cancer therapy: Endocrine resistance and innovative drug design [0.03%]
靶向乳腺癌治疗的类固醇分子的发展：内分泌抗性和创新药物设计
Zahid Ahmad Dar,Ranju Bansal
Zahid Ahmad Dar
Endocrine therapy has stood as a fundamental pillar in addressing hormone receptor-positive breast cancer. Nevertheless, the emergence of resistance to these therapies poses a significant and ongoing clinical hurdle. Of late, there is a gro...
An advocacy for investigation of a "new" estrogen metabolite as a stable epoxide [0.03%]
一种关于研究一种新的雌激素代谢产物作为稳定环氧化物的倡议
J I Raeside
J I Raeside
This mini review addresses the need to draw attention to the existence of an unknown estrogen metabolite, 5α,6α-epoxy-estrone, that was identified recently. The importance of metabolism of the primary steroid hormones from the gonads and ...
Luteinizing hormone regulates seasonal steroidogenesis locally in the prostate of the muskrat (Ondatra zibethicus) [0.03%]
黄体生成素通过局部作用调节麝鼠前列腺的季节性类固醇生成作用
Huan Yu,Pengyu Chen,Qingjing Gao et al.
Huan Yu et al.
The prostate is one of the important androgen-dependent organs in the male reproductive system. Although its ability for local steroid hormone synthesis is recognized, the regulatory mechanisms, particularly the role of hormones and the sea...
Tissue-Predominant Estrogen Metabolic Remodeling in Adenomyosis Revealed by LC-MS/MS Profiling [0.03%]
液相色谱串联质谱分析法揭示子宫腺肌症组织特异性雌激素代谢重塑现象
Qing Wang,BoYang Liu,Lei Kuang et al.
Qing Wang et al.
Adenomyosis (AM) is an estrogen-dependent gynecological disorder in which local steroid handling may contribute to clinical heterogeneity. To characterize estrogen metabolic features in AM, we used liquid chromatography-tandem mass spectrom...
Luteinizing Hormone Regulates Testosterone Biosynthesis via the cAMP/PKA-CREB Pathway in Leydig Cells of Tibetan Sheep [0.03%]
促黄体素通过cAMP/PKA-CREB信号通路调节西藏羊睾丸间质细胞雄激素合成
Minqing Liu,Yangyang Pan,Meng Wang et al.
Minqing Liu et al.
Luteinizing hormone (LH), a pivotal gonadotropin, governs the physiological functions of Leydig cells (LCs) and testicular testosterone biosynthesis, and plays an indispensable role in regulating reproductive capacity and gonadal function i...
Lower androgen sulfate metabolites in women with hypermobile Ehlers-Danlos syndrome may be associated with changed metabolism and disposition [0.03%]
具有高移动性血管炎型埃勒斯-丹洛斯综合征的女性其雄激素硫酸盐代谢物较低可能与代谢和处置改变有关
Sarrah L Hannon,Jennifer Andrews,Christina Laukaitis
Sarrah L Hannon
Hypermobile Ehlers-Danlos Syndrome (hEDS), characterized by joint hypermobility and multisystem involvement, is the most common type of EDS. Its comorbidities are wide-ranging, reflecting the involvement of connective tissue and its role in...
Podophyllotoxin induces testicular toxicity via the microbiota-gut-testis axis based on the toxicological evidence chain concept [0.03%]
毒理学证据链概念下的鬼臼毒素通过微生物群-肠-睾丸轴诱导睾丸毒性
Yuanyang Shao,Yu Wang,Yihang Dai et al.
Yuanyang Shao et al.
Podophyllotoxin (PPT), a natural lignan with well-established antitumor efficacy and well-documented ovarian toxicity, was first investigated for its potential testicular toxicity in male Sprague-Dawley rats, following the guidance of the T...
GPR56 regulates the expression of key androgen-target genes via G13-Rho-PKN1 axis and is overexpressed in prostate cancer [0.03%]
GPR56通过G13-Rho-PKN1轴调控关键雄激素靶基因的表达并在前列腺癌中过表达
Versha Dahiya,Mukesh Balyan,Harsh Sharma et al.
Versha Dahiya et al.
Androgens and the androgen receptor (AR) play critical roles in prostate cancer (PCa) development and progression. Consequently, primary treatment strategies target either androgen synthesis or androgen-AR interactions. Although initially e...
Comparison of vitamin D metabolites associated with preterm birth in a cohort of Black pregnant women [0.03%]
一项关于黑人孕妇群体中与早产相关的维生素D代谢物的比较研究
Jennifer Woo,Thomas Guffey,Jenny Hoang et al.
Jennifer Woo et al.
Vitamin D deficiency during pregnancy has been associated with increased risk for preterm birth (PTB). However, it is unclear if total 25-hydroxyvitamin D [25(OH)D], the primary measure of vitamin D status in clinical practice, accurately r...