Deciphering aldosterone deficiency and pseudodeficiency in infancy by targeted GC-MS urinary steroid metabotyping [0.03%]
婴儿盐皮质激素抵抗症的尿液甾体代谢组学研究
Huijie Li,Jörn Pons-Kühnemann,Michaela F Hartmann et al.
Huijie Li et al.
Disorders of isolated deficient aldosterone action involve insufficient production of aldosterone caused by aldosterone synthase deficiency (ASD) type I or type II (formerly named corticosterone methyl oxidase (CMO) deficiency type I or typ...
Estrogen deficiency-induced lipid dysregulation in menopause: Mechanisms, metabolic consequences, and therapeutic strategies [0.03%]
绝经引起的雌激素缺乏与脂质紊乱：机制、代谢后果及治疗策略
Alfi Sophian
Alfi Sophian
Menopause is a universal physiological transition marked by the permanent cessation of ovarian estrogen secretion, with far-reaching consequences for cardiometabolic health. Among these consequences, lipid dysregulation stands as one of the...
Pentadecanoic acid as a potential endogenous mTOR modulator for age-related female infertility: Mechanistic insights, molecular docking evidence, and therapeutic perspectives [0.03%]
十五烷酸作为年龄相关女性不孕的潜在内源性mTOR调节剂：机制见解、分子对接证据和治疗前景
Reni Kalfin,Sidharth Mehan,Rajaram Samant et al.
Reni Kalfin et al.
Age-related female infertility is a major reproductive health challenge that accelerates sharply after the age of 34, primarily due to declining oocyte quality, increased chromosomal abnormalities, and impaired embryonic developmental compe...
Exploring the Putative Role of EGFR in Prostate Cancer: Interactions with Androgen and Estrogen Receptors [0.03%]
探索EGFR在前列腺癌中的作用：与雄激素受体和雌激素受体的相互作用
G M Gonçalves,D S Souza,Crm Costa et al.
G M Gonçalves et al.
The epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor that plays a critical role in regulating cell proliferation, survival, and differentiation. Aberrant activation or overexpression of EGFR has been obser...
Development of steroidal molecules for targeted breast cancer therapy: Endocrine resistance and innovative drug design [0.03%]
靶向乳腺癌治疗的类固醇分子的发展：内分泌抗性和创新药物设计
Zahid Ahmad Dar,Ranju Bansal
Zahid Ahmad Dar
Endocrine therapy has stood as a fundamental pillar in addressing hormone receptor-positive breast cancer. Nevertheless, the emergence of resistance to these therapies poses a significant and ongoing clinical hurdle. Of late, there is a gro...
An advocacy for investigation of a "new" estrogen metabolite as a stable epoxide [0.03%]
一种关于研究一种新的雌激素代谢产物作为稳定环氧化物的倡议
J I Raeside
J I Raeside
This mini review addresses the need to draw attention to the existence of an unknown estrogen metabolite, 5α,6α-epoxy-estrone, that was identified recently. The importance of metabolism of the primary steroid hormones from the gonads and ...
Luteinizing hormone regulates seasonal steroidogenesis locally in the prostate of the muskrat (Ondatra zibethicus) [0.03%]
黄体生成素通过局部作用调节麝鼠前列腺的季节性类固醇生成作用
Huan Yu,Pengyu Chen,Qingjing Gao et al.
Huan Yu et al.
The prostate is one of the important androgen-dependent organs in the male reproductive system. Although its ability for local steroid hormone synthesis is recognized, the regulatory mechanisms, particularly the role of hormones and the sea...
Tissue-Predominant Estrogen Metabolic Remodeling in Adenomyosis Revealed by LC-MS/MS Profiling [0.03%]
液相色谱串联质谱分析法揭示子宫腺肌症组织特异性雌激素代谢重塑现象
Qing Wang,BoYang Liu,Lei Kuang et al.
Qing Wang et al.
Adenomyosis (AM) is an estrogen-dependent gynecological disorder in which local steroid handling may contribute to clinical heterogeneity. To characterize estrogen metabolic features in AM, we used liquid chromatography-tandem mass spectrom...
Luteinizing Hormone Regulates Testosterone Biosynthesis via the cAMP/PKA-CREB Pathway in Leydig Cells of Tibetan Sheep [0.03%]
促黄体素通过cAMP/PKA-CREB信号通路调节西藏羊睾丸间质细胞雄激素合成
Minqing Liu,Yangyang Pan,Meng Wang et al.
Minqing Liu et al.
Luteinizing hormone (LH), a pivotal gonadotropin, governs the physiological functions of Leydig cells (LCs) and testicular testosterone biosynthesis, and plays an indispensable role in regulating reproductive capacity and gonadal function i...
Lower androgen sulfate metabolites in women with hypermobile Ehlers-Danlos syndrome may be associated with changed metabolism and disposition [0.03%]
具有高移动性血管炎型埃勒斯-丹洛斯综合征的女性其雄激素硫酸盐代谢物较低可能与代谢和处置改变有关
Sarrah L Hannon,Jennifer Andrews,Christina Laukaitis
Sarrah L Hannon
Hypermobile Ehlers-Danlos Syndrome (hEDS), characterized by joint hypermobility and multisystem involvement, is the most common type of EDS. Its comorbidities are wide-ranging, reflecting the involvement of connective tissue and its role in...