Polymorphisms in immune checkpoint genes might influence bladder cancer risk and clinical outcome [0.03%]
免疫检查点基因多态性可能影响膀胱癌发病风险及临床预后
Anna Andrzejczak,Wojciech Krajewski,Emilia Jaskuła et al.
Anna Andrzejczak et al.
Background: In addition to well-established immune checkpoints (ICs), such as CTLA-4, PD-1, PD-L1, increasing attention is being directed toward next-generation ICs, including TIM-3, Gal-9, LAG-3, BTLA, HVEM, and CD160. S...
An integrated immunogenetic network architecture linking antigen processing and innate immune activation in Ankylosing spondylitis [0.03%]
一种集成免疫遗传网络架构，可连接银屑病关节炎中的抗原处理和先天性免疫激活
Karina Martínez-Flores,Yessica Zamudio-Cuevas,Ambar López-Macay et al.
Karina Martínez-Flores et al.
Ankylosing spondylitis (AS) is a polygenic inflammatory disease in which antigen presentation and innate immune activation converge. While HLA-B27 is the strongest genetic determinant, other loci, such as ERAP1, DEFB1, MICA, and NLRP3, also...
Translational Gaps in Immuno-AI: From algorithmic accuracy to clinical trust [0.03%]
免疫AI的转化差距：从算法准确性到临床信任
Emmanuel O Oisakede,Raphael Igbarumah Ayo Daniel,Olabanke Florence Olawuyi et al.
Emmanuel O Oisakede et al.
Artificial intelligence has shown remarkable promise in predicting patient responses to immune checkpoint inhibitors across cancers. However, despite high statistical performance, clinical translation remains minimal. This disconnect betwee...
Challenges of chimerism analysis using Next-Generation sequencing in a patient with complex chromosomal alterations [0.03%]
复杂染色体异常患者接受下一代测序供体嵌合体分析的挑战
Xing Li,Eros Qama,K H Ramesh et al.
Xing Li et al.
The impact of chromosomal abnormalities on chimerism analysis by next generation sequencing (NGS) has not been explored. Here we report a case of cutaneous T-cell lymphoma (CTCL)/ Sézary syndrome with unusual chimerism findings caused by g...
Association of the IL6 rs1800795 polymorphism with COVID-19 clinical severity in a Brazilian population [0.03%]
IL6基因多态性与巴西新冠肺炎患者病情严重程度的相关性分析
Gabriela Dias Rocha,Ana Tércia Paulo Silva,Anderson da Costa Armstrong et al.
Gabriela Dias Rocha et al.
A dysregulated inflammatory response is a central mechanism underlying severe COVID-19, with elevated serum IL-6 and TNF-α levels consistently associated with increased disease severity and mortality. Growing evidence indicates that host g...
Viral-Induced autoimmune Disorders: Mechanistic insights and emerging concepts [0.03%]
病毒诱发自身免疫病：机制见解与新兴概念
Aruna Rajalingam,Anjali Ganjiwale
Aruna Rajalingam
Autoimmune disorders (ADs) result from a complex interaction of genetic predisposition and environmental triggers, with viral infections identified as primary causes. This review summarizes current evidence on how viruses-including Epstein-...
Cannabidiol modulates classical and non-classical hla expression in human choriocarcinoma cell line [0.03%]
大麻二酚调节人绒膜癌细胞系的经典和非经典HLA表达
Kevin I Martínez,María B Palma,Fernando J Sepúlveda et al.
Kevin I Martínez et al.
Cannabidiol (CBD) modulates diverse signaling pathways with potential relevance to tumor immune escape; however, its impact on the regulation of classical and non-classical HLA class I molecules remains incompletely understood. Here, we exa...
Suraksha Agrawal
Suraksha Agrawal
Pregnancy represents a unique immunological paradox in which the maternal immune system must tolerate the semi-allogeneic fetus expressing paternal antigens. The success of pregnancy depends on a highly coordinated network of immune toleran...
Differential distribution of HLA-A, HLA-B, and HLA-DRB1 allele groups in Iranian pediatric and adult patients with acute lymphoblastic Leukemia: A Case-Control study [0.03%]
伊朗儿童及成人急性淋巴细胞白血病患者中HLA-A、HLA-B和HLA-DRB1等位基因群的分布差异：一项病例对照研究
Farzad Ghandehari,Fatemeh Mirzaei,Seppo Meri et al.
Farzad Ghandehari et al.
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Biological differences between pediatric and adult ALL suggest that inherited immunogenetic factors, such as HLA polymorphisms, may influence susceptibility in an age-d...
Comprehensive analysis of TNF-alpha gene polymorphism: a computational approach [0.03%]
肿瘤坏死因子-α基因多态性的全面分析——一种计算方法
Kajal Gaba,Samridhi Pushkarna,Parveen Malhotra et al.
Kajal Gaba et al.
Background: TNF-alpha, a potent cytokine produced by immune cells, regulates inflammation and immune responses. Understanding the genetic variations in TNF-alpha gene nsSNP and regulatory SNPs within the UTRs can help in ...