Revisiting the literature on gastric CBD-to-THC conversion: contextualizing conflicting evidence [0.03%]
重新审视胃幽门部位大麻二酚转化为四氢大麻酚的文献：厘清相互矛盾的证据
Jens B Simonsen,Heidi Ziegler Bruun,Julia Hoeng et al.
Jens B Simonsen et al.
Preclinical and clinical studies suggest that cannabidiol (CBD) holds therapeutic promise across a range of indications. However, a major barrier to realizing CBD's full therapeutic potential is its inherently low oral bioavailability, part...
In Vitro Evaluation of Lornoxicam Liquitablets: Permeability, Anti-Inflammatory Action, Cytotoxicity, and Stability [0.03%]
体外评价洛尼昔康液体药剂：渗透性、抗炎作用、细胞毒性和稳定性
Alaa Gamiel,Dóra Paróczai,Katalin Burian et al.
Alaa Gamiel et al.
Background: Lornoxicam (LXM) is a potent non-steroidal anti-inflammatory drug (NSAID), characterised by low aqueous solubility, which limits its oral bioavailability and is frequently associated with gastrointestinal adve...
Drugs solubility parameter prediction using modified Cubic Plus Chain equation of state [0.03%]
基于改进的CPC状态方程的药物溶解度参数预测
Arwa Sultan Alqahtani,Saeed Shirazian
Arwa Sultan Alqahtani
Accurate prediction of drug solubility parameter is essential for understanding drug-solvent interactions and guiding formulation design. Experimental determination is often limited by low solubility and measurement complexity; thus, reliab...
Targeting the HSP90/miR-656 Axis to Suppress Lung Cancer Stem Cells and Overcome Autophagy-Mediated Drug Resistance in Non-Small Cell Lung Cancer [0.03%]
靶向HSP90 / miR-656轴以抑制肺癌干细胞并克服非小细胞肺癌中的自噬介导的药物抗性
Tung-Yu Tiong,Chun-Hua Wang,Vijesh Kumar Yadav et al.
Tung-Yu Tiong et al.
Background: Lung cancer remains a leading cause of cancer-related mortality worldwide, with treatment outcomes severely limited by drug resistance and tumor recurrence. Lung cancer stem cells (LCSCs) are increasingly reco...
Triplet Radio-Chemo-Immunotherapy Reprograms the PD-L1-CDK6 Axis to Remodel the Tumor Microenvironment and Overcome Immune Resistance in Head and Neck Cancer [0.03%]
三联体放化疗免疫治疗重新编程PD-L1-CDK6轴以重塑肿瘤微环境并克服头颈癌的免疫耐药性
Chin-Sheng Huang,Chih-Ming Huang,Ming-Shou Hsieh et al.
Chin-Sheng Huang et al.
Head and neck squamous cell carcinoma (HNSCC) remains a highly aggressive malignancy with limited therapeutic success and frequent resistance to standard chemoradiotherapy. Beyond its cytotoxic effects, radiotherapy (RT) has emerged as a po...
Investigating gut microbiota and their metabolites as biomarkers for tacrolimus pharmacokinetic variability [0.03%]
探究肠道微生物及其代谢物作为他克莫司药代动力学变异生物标志物的作用
Yan Zhang,Linkun Hu,Xiaoliang Ding et al.
Yan Zhang et al.
Tacrolimus (TAC), a cornerstone immunosuppressant in transplantation, presents a clinical challenge due to its narrow therapeutic index and substantial interindividual pharmacokinetic (PK) variability. This exploratory study investigated th...
A Natural Deep Eutectic System modulates the inflammatory microenvironment and restores pro-regenerative cell functions in in vitro models of chronic wounds [0.03%]
一种天然深共熔混合体系调节慢性伤口体外模型的炎症微环境并重塑促再生细胞功能
Paulina Hernández,Constanza Cárcamo,Fernando Ezquer et al.
Paulina Hernández et al.
Background: Chronic wounds are characterized by persistent inflammatory microenvironments that impair angiogenesis, fibroblast migration, and keratinocyte re-epithelialization. Sustained inflammation disrupts regenerative...
COMBINED SECOND HARMONIC AND LINEAR LIGHT SCATTERING AS A TOOL FOR SOLUBILITY AND AGGREGATION SCREENING [0.03%]
结合二次谐波和拉曼光散射技术用于药物溶解度及聚集倾向的筛选研究
Jitka Kalasová,Orly Tarun,Martin Kuentz
Jitka Kalasová
Poor aqueous solubility and complex supersaturation behaviour of small-molecule drugs require rapid, material-sparing analytical tools that capture incipient aggregation and phase separation events under non-equilibrium conditions. This wor...
Evaluation of Transplacental Clearance Prediction Methods in Maternal-Fetal PBPK Modeling: Implications for Predicting Fetal Drug Exposure [0.03%]
胎盘屏障清除率预测方法的评价及对药物胎儿暴露量预测的影响研究
Qiufen Yin,Yunan Yan,Yehua Xie et al.
Qiufen Yin et al.
Background: Accurate prediction of fetal drug exposure is essential for optimizing pharmacotherapy but remains challenging due to limited clinical data. Maternal-fetal physiologically based pharmacokinetic (m-f PBPK) mode...
Integrated Formulation and Thermal Modulation Strategies for Enhancing Anti-Inflammatory Transdermal Delivery of Dracorhodin and Ketoprofen [0.03%]
兼具美白和抗炎功能的冬青红素和酮咯酸透皮给药体系的研究
Zhixiong Wang,Renhua Fang,Yi He et al.
Zhixiong Wang et al.
Transdermal patches are widely used for local anti-inflammatory therapy, but their delivery efficiency is often limited by the barrier function of the stratum corneum. This study aimed to develop an optimized dracorhodin transdermal patch a...