Targeting the HSP90/miR-656 Axis to Suppress Lung Cancer Stem Cells and Overcome Autophagy-Mediated Drug Resistance in Non-Small Cell Lung Cancer [0.03%]
靶向HSP90 / miR-656轴以抑制肺癌干细胞并克服非小细胞肺癌中的自噬介导的药物抗性
Tung-Yu Tiong,Chun-Hua Wang,Vijesh Kumar Yadav et al.
Tung-Yu Tiong et al.
Background: Lung cancer remains a leading cause of cancer-related mortality worldwide, with treatment outcomes severely limited by drug resistance and tumor recurrence. Lung cancer stem cells (LCSCs) are increasingly reco...
Triplet Radio-Chemo-Immunotherapy Reprograms the PD-L1-CDK6 Axis to Remodel the Tumor Microenvironment and Overcome Immune Resistance in Head and Neck Cancer [0.03%]
三联体放化疗免疫治疗重新编程PD-L1-CDK6轴以重塑肿瘤微环境并克服头颈癌的免疫耐药性
Chin-Sheng Huang,Chih-Ming Huang,Ming-Shou Hsieh et al.
Chin-Sheng Huang et al.
Head and neck squamous cell carcinoma (HNSCC) remains a highly aggressive malignancy with limited therapeutic success and frequent resistance to standard chemoradiotherapy. Beyond its cytotoxic effects, radiotherapy (RT) has emerged as a po...
Investigating gut microbiota and their metabolites as biomarkers for tacrolimus pharmacokinetic variability [0.03%]
探究肠道微生物及其代谢物作为他克莫司药代动力学变异生物标志物的作用
Yan Zhang,Linkun Hu,Xiaoliang Ding et al.
Yan Zhang et al.
Tacrolimus (TAC), a cornerstone immunosuppressant in transplantation, presents a clinical challenge due to its narrow therapeutic index and substantial interindividual pharmacokinetic (PK) variability. This exploratory study investigated th...
A Natural Deep Eutectic System modulates the inflammatory microenvironment and restores pro-regenerative cell functions in in vitro models of chronic wounds [0.03%]
一种天然深共熔混合体系调节慢性伤口体外模型的炎症微环境并重塑促再生细胞功能
Paulina Hernández,Constanza Cárcamo,Fernando Ezquer et al.
Paulina Hernández et al.
Background: Chronic wounds are characterized by persistent inflammatory microenvironments that impair angiogenesis, fibroblast migration, and keratinocyte re-epithelialization. Sustained inflammation disrupts regenerative...
COMBINED SECOND HARMONIC AND LINEAR LIGHT SCATTERING AS A TOOL FOR SOLUBILITY AND AGGREGATION SCREENING [0.03%]
结合二次谐波和拉曼光散射技术用于药物溶解度及聚集倾向的筛选研究
Jitka Kalasová,Orly Tarun,Martin Kuentz
Jitka Kalasová
Poor aqueous solubility and complex supersaturation behaviour of small-molecule drugs require rapid, material-sparing analytical tools that capture incipient aggregation and phase separation events under non-equilibrium conditions. This wor...
Evaluation of Transplacental Clearance Prediction Methods in Maternal-Fetal PBPK Modeling: Implications for Predicting Fetal Drug Exposure [0.03%]
胎盘屏障清除率预测方法的评价及对药物胎儿暴露量预测的影响研究
Qiufen Yin,Yunan Yan,Yehua Xie et al.
Qiufen Yin et al.
Background: Accurate prediction of fetal drug exposure is essential for optimizing pharmacotherapy but remains challenging due to limited clinical data. Maternal-fetal physiologically based pharmacokinetic (m-f PBPK) mode...
Integrated Formulation and Thermal Modulation Strategies for Enhancing Anti-Inflammatory Transdermal Delivery of Dracorhodin and Ketoprofen [0.03%]
兼具美白和抗炎功能的冬青红素和酮咯酸透皮给药体系的研究
Zhixiong Wang,Renhua Fang,Yi He et al.
Zhixiong Wang et al.
Transdermal patches are widely used for local anti-inflammatory therapy, but their delivery efficiency is often limited by the barrier function of the stratum corneum. This study aimed to develop an optimized dracorhodin transdermal patch a...
Corrigendum to "iRGD-modified peptide-drug conjugate improves brain delivery and antitumor efficacy in glioblastoma" [European Journal of Pharmaceutical Sciences 224 (2026) 107599] [0.03%]
“iRGD修饰的肽-药物偶联物可提高胶质母细胞瘤的大脑递送和抗肿瘤疗效”的勘误表 [欧洲药剂学杂志，第224期（2021年）107599]
Danyang Yun,Lizhen Mu,Juan Liu et al.
Danyang Yun et al.
Microenvironment-Driven Modulation of Diiron(I) Bis-Cyclopentadienyl Complex Activity in Advanced Cancer Models [0.03%]
微环境驱动的二价铁双环戊二烯配合物在晚期癌症模型中的活性调节
Giada Bassi,Lorenzo Biancalana,Mohamed Saqawa et al.
Giada Bassi et al.
The clinical success of platinum-based drugs such as cisplatin, carboplatin, and oxaliplatin is still limited by severe side effects and the frequent emergence of resistance, highlighting the need for new metal-based anticancer agents. Amon...
Airway deposition of two fixed-dose triple combination pMDI drugs at different inhalation flow rates and insertion angles [0.03%]
不同吸入流量和插入角度下的两种固定剂量三联气雾剂药物在呼吸道的沉积分布
Árpád Farkas,Attila Nagy,Balázs Sánta et al.
Árpád Farkas et al.
The objective of this study was to establish a robust experimental and computational framework for characterizing pressurized metered-dose inhaler (pMDI) plumes and quantifying regional deposition fractions of two triple-combination aerosol...