Lu Wang,Yuan Cao,Yiqi Wu et al.
Lu Wang et al.
Sepsis, a life-threatening condition characterized by systemic inflammatory responses, remains a significant challenge in clinical settings due to its complex pathogenesis and limited therapeutic strategies. Central to this conundrum is the...
Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy [0.03%]
免疫细胞中的铁死亡及其在肿瘤免疫和癌症治疗中的意义
Jianbo Gao,Xiaoling Zhang,Yu&#x;e Liu et al.
Jianbo Gao et al.
Ferroptosis, an iron-dependent cell death driven by lipid peroxidation, has emerged as a pivotal mechanism in cancer biology with significant therapeutic potential. Immune cells, both innate and adaptive, are integral in detecting and elimi...
Leptin as a mechanistic link between obesity and systemic lupus erythematous [0.03%]
肥胖与系统性红斑狼疮之间的 leptin 介导机制联系研究进展
Daniel J García-Domínguez,Lourdes Hontecillas-Prieto,Laura Lucenilla-Barrenechea et al.
Daniel J García-Domínguez et al.
Systemic lupus erythematosus (SLE) is a chronic, multisystemic, heterogenic and complex autoimmune disease. Similarly, obesity is a chronic condition characterized by excessive adipose tissue and a sustained state of inflammation. Both cond...
Cytokine symphony: Deciphering the tumor microenvironment and metastatic axis in oral cancer [0.03%]
细胞因子交响曲：解码口腔癌的肿瘤微环境和转移轴
Mukesh Kumar Manickasamy,Ravichandran Vishwa,Bandari BharathwajChetty et al.
Mukesh Kumar Manickasamy et al.
Oral cancer remains one of the deadliest diseases due to its aggressive nature, high metastatic potential, and limited therapeutic success. The tumor microenvironment (TME) serves as a central regulator in the metastasis of oral cancer by s...
Neuroprotective properties of ciliary neurotrophic factor in the retina for the treatment of macular telangiectasia type 2 [0.03%]
睫状神经营养因子在视网膜中的神经保护特性可治疗黄斑 telangiectasia II型疾病
Arne Nystuen,Eugene Gonzalez-Lopez,Konrad A Kauper et al.
Arne Nystuen et al.
Neurotrophic factors are a family of proteins that promote the growth and survival of both developing and mature neurons. Extensive preclinical studies have demonstrated neuroprotective properties conferred by ciliary neurotrophic factor (C...
Exploring AI tools and multi-omics for precision medicine in lung cancer therapy [0.03%]
探索AI工具和多组学在肺癌治疗精确诊疗中的应用
Arvindra Sahu,Priyanshu Nema,Devraj Rajak et al.
Arvindra Sahu et al.
Lung cancer is a leading cause of cancer-related mortality worldwide, characterized by the uncontrolled growth and spread of abnormal cells. Despite constant progress in diagnosis and treatment of lung cancer remains highly challenging. Pre...
Targeting macrophage-directed pathological processes in pancreatic ductal adenocarcinoma: Mechanisms and targeted therapies [0.03%]
胰腺导管腺癌中针对巨噬细胞相关病理过程的机制及靶向治疗
Zhou Chen,Defeng Guan,Yan Wang et al.
Zhou Chen et al.
Macrophages support the malignant transformation of pancreatic ductal adenocarcinoma cells by secreting cytokines and enzymes, which enhance tumor invasiveness and metastatic potential. In addition to promoting tumor growth, macrophages con...
Metabolic Regulation of cGAS-STING Signaling in the Tumor Microenvironment: Dual Immune Roles and Therapeutic Implications [0.03%]
肿瘤微环境中cGAS-STING信号的代谢调节：双重免疫作用和治疗意义
Yong Wu,Wen-Min Lu,Qian-Ru Cui et al.
Yong Wu et al.
The cGAS-STING pathway, a cytosolic DNA-sensing mechanism, plays a context-dependent pivotal role in tumor immunity and tumor microenvironment (TME) remodeling. Acute activation of this pathway promotes type I interferon (IFN-I) and pro-inf...
The central role of CXCL10-CXCR3 signaling in neuroinflammation and neuropathology [0.03%]
CXCL10-CXCR3信号在神经炎症和神经病理中的核心作用
Alexandro A Bufi,Julia Di Stefano,Andrea Papait et al.
Alexandro A Bufi et al.
The role of neuroinflammation is becoming increasingly prominent as our understanding of the mechanisms underlying central nervous system disorders advances. What makes this phenomenon particularly intriguing from a clinical perspective is ...
Nuclear receptors in pulmonary hypertension: From pathophysiological mechanisms to clinical implications [0.03%]
核受体在肺动脉高压中的作用：从病理生理机制到临床意义
Tianxin Xiong,Yi Li,Hong Chen et al.
Tianxin Xiong et al.
Pulmonary hypertension is one of the most intractable cardiovascular diseases in the world today. The current pharmacological treatments can temporarily relieve symptoms, but the therapeutic effect is unsatisfactory in advanced pulmonary hy...