Manoj Kumar Gupta,Ramakrishna Vadde
Manoj Kumar Gupta
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related deaths worldwide. Chronic inflammation and immune dysregulation, often driven by viral infections or metabolic disorders, play a si...
Mechanisms and routes of G-protein coupled receptor-mediated Tau degradation in Alzheimer's disease [0.03%]
阿尔茨海默病中G蛋白偶联受体介导的Tau蛋白降解机制和途径
Vaishnavi Ananthanarayana,Hariharakrishnan Chidamabram,Periyasamy Govindaraj et al.
Vaishnavi Ananthanarayana et al.
Alzheimer's disease is the most prevalent form of dementia and major Tauopathies characterized by memory loss and cognitive decline. Important pathological features include extracellular build-up of amyloid-β peptides which form senile pla...
Cardiac and pericardial inflammatory changes and post-cardiac surgery atrial fibrillation [0.03%]
心脏和心包炎症变化与术后房颤的关系
Sophie Spicer,Amin Hasheminia,Sneha Kandi et al.
Sophie Spicer et al.
Postoperative atrial fibrillation (POAF) is one of the most common complications after cardiac surgery with an estimated incidence of up to 20-55 % of patients. POAF is associated with higher morbidity, prolonged hospital stays, and increas...
Role of growth factors and their interplay during oligodendroglial differentiation and maturation [0.03%]
生长因子及其在少突胶质细胞分化和成熟过程中的相互作用的作用
Shrey Dwivedi,Sneha Ranjan,Shuvajit Das et al.
Shrey Dwivedi et al.
Oligodendrocytes (OLs) facilitate the myelination within the central nervous system (CNS). Neuronal axons are originally devoid of myelin and acquire myelination during development. OLs are derived from oligodendrocyte precursor cells (OPCs...
Targeting cGAS-STING signaling and cell death modes in cancer and autoimmune diseases [0.03%]
靶向cGAS-STING信号通路和细胞死亡模式以治疗癌症和自身免疫性疾病
Jing Zhou,Yi Yang,Yaning Fang et al.
Jing Zhou et al.
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is an important component of innate immunity, involved in regulating various pathological conditions such as cancer, autoimmune and inflammatory dis...
Sergio Giunta,Angelica Giuliani,Jacopo Sabbatinelli et al.
Sergio Giunta et al.
Long COVID is a chronic condition that arises after SARS-CoV-2 infection and is characterized by persistent and often debilitating symptoms, such as fatigue, cognitive dysfunction ("brain fog"), dyspnea, and autonomic disturbances. Increasi...
Priya Solanki,Sushmita Jha
Priya Solanki
Epilepsy is a chronic, non-communicable neurological disease that affects more than 50 million people worldwide, making it one of the most common neurological diseases globally. Epilepsy is characterized by recurrent and unprovoked interrup...
Lu Wang,Yuan Cao,Yiqi Wu et al.
Lu Wang et al.
Sepsis, a life-threatening condition characterized by systemic inflammatory responses, remains a significant challenge in clinical settings due to its complex pathogenesis and limited therapeutic strategies. Central to this conundrum is the...
Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy [0.03%]
免疫细胞中的铁死亡及其在肿瘤免疫和癌症治疗中的意义
Jianbo Gao,Xiaoling Zhang,Yu&#x;e Liu et al.
Jianbo Gao et al.
Ferroptosis, an iron-dependent cell death driven by lipid peroxidation, has emerged as a pivotal mechanism in cancer biology with significant therapeutic potential. Immune cells, both innate and adaptive, are integral in detecting and elimi...
Leptin as a mechanistic link between obesity and systemic lupus erythematous [0.03%]
肥胖与系统性红斑狼疮之间的 leptin 介导机制联系研究进展
Daniel J García-Domínguez,Lourdes Hontecillas-Prieto,Laura Lucenilla-Barrenechea et al.
Daniel J García-Domínguez et al.
Systemic lupus erythematosus (SLE) is a chronic, multisystemic, heterogenic and complex autoimmune disease. Similarly, obesity is a chronic condition characterized by excessive adipose tissue and a sustained state of inflammation. Both cond...