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Myokines and osteokines in aging-related degenerative diseases: Regulatory networks in the muscle-bone-brain axis

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This review summarizes the biological properties of key myokines (Irisin, Apelin, CLCF1, and Myostatin) and osteokines (Osteocalcin, Sclerostin, FGF23 and the RANKL/OPG system). This work provides an in-depth analysis of the age-related network imbalance mecha... ...