Regulatory B cells: changing the landscape of immunoregulation and immunotherapy [0.03%]
调节性B细胞：重塑免疫调节和免疫治疗格局
Elina A Zheremyan,Nikolai R Kon,Alina S Ustiugova et al.
Elina A Zheremyan et al.
Recent advances in understanding regulatory B cells (Bregs) as critical modulators of immune homeostasis have opened new avenues for therapeutic intervention across a broad spectrum of immune-mediated diseases. Despite compelling preclinica...
Pancreatic cancer exosomes: Their role in drug resistance and immunomodulation [0.03%]
胰腺癌外泌体：其在耐药性及免疫调节中的作用
RamaRao Malla,Charanteja Mangam,Ganji Purnachandra Nagaraju
RamaRao Malla
Pancreatic ductal adenocarcinoma (PDAC) has a low survival rate, which is primarily attributed to its aggressive metastatic potential, poor prognosis, and the rapid development of resistance to conventional therapies. Within the PDAC microe...
Arteriolar angiogenesis: implications in anti-angiogenic immunotherapy for pancreatic cancers [0.03%]
胰腺癌抗血管生成免疫治疗的动脉血管生成意义
Adam W Beck,Herbert Chen,Bin Ren
Adam W Beck
Angiogenesis, the newly formed blood vessels from preexistent ones, is essential for the progression and potential resolution of diseases. Here we introduce a view of arteriolar angiogenesis (the growth of new small arteries), and define a ...
Reprogramming natural killer cells in the tumor microenvironment: Challenges and therapeuticopportunities [0.03%]
肿瘤微环境中的自然杀伤细胞重编程：挑战与治疗机会
Wenxue Ma,Sheldon Morris,Catriona Jamieson
Wenxue Ma
Natural killer (NK) cells are central effectors of innate immunity, traditionally viewed as rapid responders capable of recognizing and eliminating malignant or virus-infected cells without prior sensitization. Their combined capacity to me...
Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies [0.03%]
调控NLRP3炎症小体治疗脓毒症：分子机制与治疗策略
Yuhui Ma,Jialei Meng,Fangyuan Sun et al.
Yuhui Ma et al.
Sepsis is a life-threatening organ dysfunction triggered by a dysregulated host response to infection, with immune homeostasis imbalance at the core of its pathological mechanism. The NACHT, leucin-rich repeat (LRR) and pyrin domain (PYD)-c...
Erratum to "TLR-Based therapeutic strategies for Hepatocellular carcinoma" [Cytokine Growth Factor Rev. Volume 85 2025 Pages 179-189] [0.03%]
关于“基于TLR的肝细胞癌治疗策略”的勘误[Cytokine Growth Factor Rev.卷85,2025,第179-189页]
Manoj Kumar Gupta,Ramakrishna Vadde
Manoj Kumar Gupta
Published Erratum
Cytokine & growth factor reviews. 2025 Sep 24:86:56. DOI:10.1016/j.cytogfr.2025.09.005 2025
Designing immunity with cytokines: A logic-based framework for programmable CAR therapies [0.03%]
基于细胞因子的免疫设计：用于可编程CAR治疗的逻辑基础框架
Saurabh Upadhyay,Kirti Upmanyu,Moustafa T Gabr
Saurabh Upadhyay
Adoptive cellular immunotherapy has transformed cancer care, with chimeric antigen receptor (CAR) T cells achieving unprecedented remission in hematologic malignancies. Yet solid tumor translation remains limited by antigen escape, hostile ...
Wiring and rewiring PANoptosis: Molecular vulnerabilities for targeting inflammatory cell death in human disease [0.03%]
重塑PANoptosis：人类疾病中炎症性细胞死亡的分子脆弱性和靶向治疗
Kirti Upmanyu,Saurabh Upadhyay
Kirti Upmanyu
PANoptosis represents a unified inflammatory cell death program that mechanistically integrates pyroptosis, apoptosis, and necroptosis through multiprotein complexes known as PANoptosomes. While prior models treated these death pathways as ...
Heat shock protein 70 (Hsp70) as a target for advancing immunotherapy in solid tumors [0.03%]
热休克蛋白70(Hsp70)作为实体瘤免疫治疗靶点的潜力
Khouloud Hachani,Mohamad Ghanem,A Graham Pockley et al.
Khouloud Hachani et al.
Heat shock protein 70 (Hsp70) is a highly conserved molecular chaperone that maintains protein homeostasis (proteostasis) under stress conditions. In cancer, Hsp70 is frequently overexpressed, where it contributes to hallmark features of ma...
Myokines and osteokines in aging-related degenerative diseases: Regulatory networks in the muscle-bone-brain axis [0.03%]
衰老相关退行性疾病中的肌肉因子和骨因子：肌骨脑轴中的调控网络
Shang Gao,Nianhu Li,Lijie Qi et al.
Shang Gao et al.
This review summarizes the biological properties of key myokines (Irisin, Apelin, CLCF1, and Myostatin) and osteokines (Osteocalcin, Sclerostin, FGF23 and the RANKL/OPG system). This work provides an in-depth analysis of the age-related net...