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Biological macromolecule-driven therapeutics in rheumatoid arthritis: Integrating drug delivery, regenerative medicine, and orthopedic repair

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Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.5-1 % of the global population, leading to joint destruction, disability, and high socioeconomic costs. While conventional therapies like DMARDs and biologics have improved outcomes, limitat... ...