Chemokines in thyroid cancer: Mechanistic insights and clinical implications [0.03%]
甲状腺癌中的趋化因子：机制见解与临床意义
Aleksandra Wiktoria Bratborska,Marek Ruchała
Aleksandra Wiktoria Bratborska
Thyroid cancer, the most prevalent endocrine malignancy, exhibits a diverse range of clinical behaviors, from indolent to highly aggressive phenotypes. Growing evidence indicates that chemokines, cytokines involved in the trafficking of leu...
Abdullah Altulea,Jamil Nehme,Marco Demaria
Abdullah Altulea
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that bridges innate immunity, cellular senescence and age‑related pathology. In this review, we describe the unique secretion mechanisms, compartment‑specific signalin...
Persistent spatial immune responses in glioblastoma following oncolytic virus therapy [0.03%]
肿瘤内溶瘤病毒治疗后的胶质母细胞瘤小鼠的持续空间免疫反应
Wenxue Ma,Teresa Sposito,Kendale Wirtjes et al.
Wenxue Ma et al.
Glioblastoma (GBM) remains highly resistant to immunotherapy due to limited T-cell infiltration and a profound immunosuppressive tumor microenvironment (TME). A recent first-in-human clinical trial of the oncolytic herpes simplex virus rQNe...
The intricate relationship between cytokines and galectins in immune modulation [0.03%]
细胞因子和半乳糖凝集素在免疫调节中的复杂关系
Shannah M Gennesse,Rory R Koenen,Victor L J L Thijssen
Shannah M Gennesse
The human immune system is a complex defense mechanism that protects the body against external and internal threats. Disruption of an effective immune response can lead to detrimental effects, such as autoimmune diseases or cancer. To ensur...
Therapeutic targeting of toll-like receptor pathways in tumor-associated macrophages [0.03%]
靶向肿瘤相关巨噬细胞中 Toll 样受体途径的治疗
Lei Wang,Yinghua Li,Zehua He et al.
Lei Wang et al.
Tumor-associated macrophages (TAMs) are central regulators of the tumor microenvironment (TME), shaping immune suppression, tumor progression, and therapeutic resistance. Toll-like receptors (TLRs) orchestrate innate immune activation and r...
Cytokine circuitry in pancreatic cancer: Targets for overcoming immune checkpoint inhibitor resistance in PDAC [0.03%]
胰腺癌中的细胞因子回路：克服免疫检查点抑制剂耐药性的PDAC靶点
Dhanisha Sulekha Suresh,Maria Fernanda Salcedo-Noriega,Utpreksha Vaish et al.
Dhanisha Sulekha Suresh et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a poor prognosis due to its complex and highly immunosuppressive tumor microenvironment (TME). The PDAC TME, characterized by dense desmoplasia and enhanced infiltra...
Cytokine storm divergence in viral infections of the upper respiratory tract [0.03%]
呼吸道病毒感染中的细胞因子风暴分歧
Keda Chen,Qiuyi Xu,Jiaxuan Li et al.
Keda Chen et al.
Cytokine storm (CS) is a pathological state of dysregulated, hyperactive host immunity that arises in the context of infection, malignancy, or immunotherapy. CS is characterized by the sustained, markedly elevated release of multiple pro-in...
The role of neurotransmitter signaling in colorectal cancer progression: Opportunities for drug repurposing [0.03%]
神经递质信号在结直肠癌进展中的作用：药物再利用的机会
He Jiang,Guangming Zhang,Wanjun Sun et al.
He Jiang et al.
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with treatment challenges often arising from drug resistance and the complexity of the tumor microenvironment (TME). Emerging evidence has repositioned t...
Cytokine MicroRNA regulatory networks in colorectal cancer: Contemporary research insights and mechanistic analysis [0.03%]
结直肠癌细胞因子微小核糖核酸调节网络的当代研究见解及机制分析
Aneth Ochoa Negrete,Vanessa Duran,Natalie Gierat et al.
Aneth Ochoa Negrete et al.
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Effective CRC screening in the United States has reduced incidence of CRC in populations over 50 years of age. Early-onset CRC is emerging as a significa...
Spatiotemporal dynamic regulation of the CX3CL1-CX3CR1 axis: A double-edged sword in the tumor immune microenvironment and new strategies for precision therapy [0.03%]
CX3CL1-CX3CR1轴的时空动态调节：肿瘤免疫微环境中的双刃剑及精准治疗新策略
Jingtian Liang,Wenlong Zhu,Ruohan Pan et al.
Jingtian Liang et al.
The CX3CL1-CX3CR1 signaling axis is a key yet functionally contradictory regulatory hub within the tumor immune microenvironment (TME), with its output shaped by spatiotemporal dynamics. This review seeks to address the core scientific ques...