Role of FOXO3 in regulation of redox homeostasis and promotion of red blood cell longevity in sickle cell disease
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Sickle cell disease (SCD) is a severe monogenic red blood cell (RBC) disorder that follows a simple Mendelian mode of inheritance. SCD is characterized by hemoglobin S polymerization under deoxygenated conditions, leading to chronic hemolysis and vaso-occlusiv... ...
