Balancing Stability and Cleavability of Magnetoelectric Nanovesicles for Wireless and Noninvasive Deep Brain Stimulation in Epilepsy Therapy [0.03%]
用于癫痫治疗的无线非侵入性深部脑刺激的磁电纳囊的稳定性和可裂解性的平衡研究
Yiran Chen,Meng Xiao,Yage Sun et al.
Yiran Chen et al.
Polymeric vesicles hold considerable promise as noninvasive delivery platforms for magnetoelectric nanoparticles (MENPs). This strategy enables wireless and noninvasive neural stimulation and offers effective therapeutic avenues for epileps...
Acid-responsive bone-targeting nanoplatform enables spatiotemporal control of osteogenesis and angiogenesis for osteoporosis rescue [0.03%]
一种酸响应的骨靶向纳米平台可在空间和时间上控制成骨和血管生成以治疗骨质疏松症
Yingqi Liu,Jie He,Xiaojing Zhang et al.
Yingqi Liu et al.
Osteoporosis (OP) poses a significant challenge in regenerative medicine due to the lack of therapeutic strategies that can intelligently respond to the local pathological microenvironment for precise intervention. To address this issue, we...
Fiber Density-Driven Mechanotransduction Reconstructs Collagen Heterogeneity in the Annulus Fibrosus [0.03%]
基于纤维密度的力学信号转导重建纤维环中胶原蛋白的空间异质性
Mingyang Qian,Yongqiang Xiao,Wei Jiang et al.
Mingyang Qian et al.
Existing annulus fibrosus (AF) repair strategies largely restore structural continuity without reconstructing native collagen heterogeneity, due to limited control over annulus fibrosus cell (AFCs) phenotypes. Here, we hypothesize that fibe...
A computationally efficient fibril-scale finite element model bridges molecular mechanisms and collagen fibril nonlinearity and failure [0.03%]
一种计算高效的原纤维尺度有限元模型连接了分子机制和胶原原纤维的非线性和失效问题
Xiwen Dai,Richard Leslie Abel,Ulrich Hansen et al.
Xiwen Dai et al.
Collagen fibrils control the mechanical integrity of many load-bearing tissues, but experimentally isolating how cross-link class, density, and spatial organization regulate fibril nonlinearity and failure remains difficult. This limits mec...
Extruded biodegradable Zn-5Cu alloys with integrated osteoimmunomodulatory, antibacterial, and anti-osteolytic properties for patellar fracture suture repair [0.03%]
具有整合的骨免疫调节、抗菌和抗骨溶解性能的可生物降解Zn-5Cu合金型材用于髌骨骨折缝合修复
Xiajin Lin,Zhengjun Lin,Hong Wu et al.
Xiajin Lin et al.
Zn-based biodegradable alloys hold promise for fracture suture-line applications, but are often limited by insufficient mechanical performance. In this study, alloying and extrusion were employed to regulate the microstructure of Zn-5Cu all...
Silk nanoengineering for in situ forming injectable ECM-inspired hydrogels [0.03%]
纳米工程丝素蛋白制备原位形成仿基质水凝胶注射液
Lin Zhu,Zixin Gao,Xinyi Chen et al.
Lin Zhu et al.
The microenvironment within hydrogels is essential for tissue regeneration and cell colonization, yet it presents a significant obstacle to the development of injectable hydrogel biomaterials. Hyaluronic acid (HA) has garnered substantial i...
Pyriphenone modification of glutaraldehyde pretreated bovine pericardium mitigates advanced glycation end products, calcification, and platelet adhesion [0.03%]
戊二醛处理后吡里菲酮修饰的牛心包膜可减轻晚期糖基化终末产物、钙化和血小板黏附
Andrey Zakharchenko,Nikia T Toomey,Ivan Alferiev et al.
Andrey Zakharchenko et al.
Heterograft biomaterials, such as glutaraldehyde-pretreated bovine pericardium (BP), are used to fabricate bioprosthetic heart valves (BHV). BHV durability is limited by structural valve degeneration (SVD), which is caused by either advance...
Breast implant surface texture is associated with distinct implant microbiome profiles in humans [0.03%]
乳房植入物表面纹理与人体内植入物微生物群谱型相关
Tim K Weltz,Shuang Peng,Andreas Larsen et al.
Tim K Weltz et al.
Surface topography of silicone breast implants modulates foreign body responses, but its connection to implant-associated microbial communities remains unclear. We analyzed the microbiome of 391 explanted breast implants from 221 patients w...
Fe3+-responsive Aggregable Gold Nanoplatform Enables siRNA-Mediated Chemoresistance Reversal and Combined Photothermal-Temozolomide Therapy for Glioblastoma [0.03%]
一种Fe³⁺响应的聚集型金纳米平台用于实现siRNA介导的化疗耐药逆转及协同光热-替莫唑胺胶质母细胞瘤治疗
Junhao Pan,Meilin Qiao,Yuan Chen et al.
Junhao Pan et al.
Glioblastoma (GBM) remains highly lethal, and standard temozolomide (TMZ) therapy is undermined by O6-methylguanine-DNA-methyltransferase (MGMT)-driven resistance. Herein, we present a Fe3+-responsive aggregable gold nanoplatform (siMGMT@P-...
A High-Performance Biodegradable Mg-Zn- Ca-Sn Alloy with Synergistic Improvement of yield strength and corrosion rate achieved by precise control of Extrusion and Microstructural Design [0.03%]
一种高性能可降解Mg-Zn-Ca-Sn合金的制备及性能研究
Yun Feng,Ze Zhang,Dingyu Jiang et al.
Yun Feng et al.
Magnesium alloys are emerging as promising candidates for biomedical applications due to their biodegradability, biocompatibility, and appropriate mechanical properties. However, achieving a balance between high strength and corrosion resis...