A pH-responsive polymeric nanovaccine with efficient endosomal escape and potent antitumor immunity for cancer treatment [0.03%]
Shucheng Zhang,Yuanzhen Su,Guanyu Jin et al.
Shucheng Zhang et al.
The efficacy of cancer vaccines is often limited by poor cytosolic antigen delivery. Here, we report a pH-responsive copolymer nanovaccine that remains inert under physiological conditions yet undergoes acid-triggered activation within endo...
Antimicrobial-potentiated colorectal cancer therapy with synchronized tumoricidal immunity via a self-deliverable nanopeptide [0.03%]
Shu-Na Wei,Chuang Cai,Jing Wang et al.
Shu-Na Wei et al.
As one of the core pathogens of colorectal cancer (CRC), fusobacterium nucleatum (Fn) contributes to tumor progression, drug-resistance, and immunosuppressive microenvironment, resulting in low therapeutic outcomes. Developing multifunction...
Age and region dependent biomechanical and ultrastructural differences in porcine white matter [0.03%]
Rujing Lei,Robert Young,Lanxi Xu et al.
Rujing Lei et al.
The biofidelity of computational models for paediatric traumatic brain injury (TBI) is dependent on age and region-specific material data that captures the brain's complex mechanical behaviour. This study performs a comprehensive, multiscal...
Jing Ru,Nan Luo,Ming Shen et al.
Jing Ru et al.
Capping materials are critical for vital pulp therapy in endodontic treatment, whereas the currently available ones remain inadequate in meeting the multiple requirements of the complex tissue defects. Herein, we report an injectable and se...
Chirality of poly(γ-glutamic acid) directs calcium nanoparticle assembly and adjuvant-like immune activation [0.03%]
Huizhu Tan,Kuirong Mao,Meiling Yu et al.
Huizhu Tan et al.
Chirality, describing the asymmetry between an object and its mirror image, plays a crucial role in biological recognition and functional material design. Translating this concept to nanoscale systems, chiral polymers can influence nanopart...
Carrier-free spherical nucleic acids engineered by coordination-competition for programmable release and cancer immunotherapy [0.03%]
Wanrui Shi,Shihao Wang,Li Rong et al.
Wanrui Shi et al.
Oligonucleotide-based therapeutics offer precise genetic and immunological modulation but meet critical barriers including instability, poor cellular uptake, and carrier-associated toxicity. Although spherical nucleic acids (SNAs) provide a...
Salmonella biomimetic Janus nanorobots reinvigorate colorectal cancer radio-immunotherapy by glycolysis inhibition and cGAS-STING activation [0.03%]
Wei Liu,Shuangjiao Sun,Ya Liu et al.
Wei Liu et al.
Colorectal cancer remains a major therapeutic challenge due to the immunosuppressive tumor microenvironment and physical barriers that limit drug delivery. Here, we present near-infrared (NIR)-II laser-actuated biomimetic nanorobots (Au-mSi...
A nitric oxide-releasing zwitterionic glycocalyx-mimetic hydrogel armored bioprosthetic valve with integrated antithrombotic, endothelialization-promoting, and immunomodulatory capacities [0.03%]
Cheng Zheng,Bangquan Wei,Xueyu Huang et al.
Cheng Zheng et al.
The global prevalence of heart valve disease (HVD) is currently increasing with the population ages, and heart valve replacement surgery is considered as the definitive treatment for HVD. Bioprosthetic heart valves (BHVs) are widely implant...
Programmable metal-nucleic acid biomineralized hydrogel for infected wound healing via mitochondrial regulation [0.03%]
Yichen Yang,Jiale Liang,Ziqi Qin et al.
Yichen Yang et al.
Chronic infected wounds represent a significant clinical challenge due to bacterial infection, dysregulated inflammation, and excessive reactive oxygen species (ROS) that impair tissue repair and are exacerbated by antibiotic resistance. To...
Intelligent delivery of autophagy-targeting chimeric peptides by engineered exosomes for the degradation of α-synuclein [0.03%]
Yuteng Zeng,Ziyan Lv,Jiayu Liang et al.
Yuteng Zeng et al.
Targeted degradation of the aggregated α-synuclein holds tremendous potential for treating Parkinson's disease (PD). However, most of the developed aggregated α-synuclein-specific degraders, e.g., autophagy-targeting chimeric peptides, ar...