Lauroylated peptide dendrimers with potent and broad-spectrum antimicrobial activity against multidrug-resistant bacteria [0.03%]
具有广谱抗菌活性的抗多重耐药细菌月桂酰肽树状聚合物
An Yan,Tianyu Zhang,Xingyu Wang et al.
An Yan et al.
Peptide dendrimers, characterized by their branched structure and densely arrayed surface amino acids or peptides, offer enhanced multivalency and unimolecular stability that collectively improve receptor engagement and bioactivity. Despite...
Preconditioned endothelialized grafts reduce stenosis and improve vascular remodeling in a rat pulmonary artery model [0.03%]
预条件的内皮化移植物可减少大鼠肺动脉模型中的狭窄并改善血管重塑
Wei Zhang,Qinzhe Xing,Séverine Ménoret et al.
Wei Zhang et al.
Pulmonary artery reconstruction is frequently required for congenital heart disease repair, yet current graft options remain limited by the scarcity of autologous conduits and the poor durability of synthetic grafts, which often fail due to...
Multi-scale assessment of scaffold-guided regeneration in human extraction sockets using an ultra-porous TiO₂ biomaterial [0.03%]
一种超多孔TiO2生物材料在人类拔牙窝支架指导再生的多尺度评价中应用研究
Reem Jamous,Ingvild Nysæther,Håvard Jostein Haugen et al.
Reem Jamous et al.
Ultra-porous TiO₂ scaffolds are architected non-degradable ceramic graft substitutes, but human evidence relating their structural integration to local tissue maturation remains limited. This exploratory study assessed scaffold-associated ...
Clinical Trial
Acta biomaterialia. 2026 Oct:223:609-621. DOI:10.1016/j.actbio.2026.08.041 2026
Biomaterial-associated factors in silicone breast implant-related pathology [0.03%]
与硅胶乳房植入物相关疾病有关的生物材料相关的因素
Neal I Callaghan,Robin Lake,Lauren Fong-Hollohan et al.
Neal I Callaghan et al.
Silicone breast implants (SBIs) are among the most common surgically-implantable medical devices, but carry high complication rates, especially in the setting of post-oncologic breast reconstruction. These complications include capsular con...
Anterior cruciate ligament overuse increases collagen fibril compliance: collagen unraveling and elevated glycosaminoglycan activity in a murine model [0.03%]
前交叉韧带劳损增加胶原纤维顺应性：鼠模型中的胶原蛋白解旋和糖胺聚糖活性升高
Kevin H Putera,Taeyong Ahn,Ben Loflin et al.
Kevin H Putera et al.
Data increasingly indicates that many anterior cruciate ligament (ACL) injuries are likely due to tissue damage accumulation and the gradual decrease in ACL strength and stiffness over time. Previous ex vivo experiments found molecular-leve...
Poly(itaconic acid) nanoparticles alleviate inflammation and multiorgan injury in sepsis by promoting nuclear factor erythroid 2-related factor 2 nuclear translocation and macrophage reprogramming [0.03%]
聚衣康酸纳米颗粒通过促进核因子E2相关因子2核转位和巨噬细胞重编程来缓解脓毒症的炎症及多器官损伤
Hao Zhang,Yining Wang,Tian Deng et al.
Hao Zhang et al.
Sepsis is a serious syndrome characterized by acute dysfunction of multiple organs, and there is a notable lack of effective preventive strategies and interventions. As a natural anti-inflammatory and antioxidant feedback regulator in the b...
Zinc-based nanoplatforms for cancer immunotherapy achieved through the cyclic GMP-AMP synthase-stimulator of interferon genes pathway: Bridging tumor metabolism and immune activation [0.03%]
基于锌的纳米平台通过cGAS-STING途径实现癌症免疫治疗：连接肿瘤代谢和免疫激活
Yizi Wang,Yutao Wang,Cheng Zhang et al.
Yizi Wang et al.
Cancer immunotherapy has substantially advanced cancer treatment; however, durable responses remain uncommon in tumors with low immunogenicity and strongly suppressive tumor microenvironments (TME). Among innate immune pathways, cyclic GMP-...
Revisiting the tension-free paradigm: Axially prestretched elastomeric nanofibrillar grafts restore artery-like axial biomechanics in a preclinical model [0.03%]
重新审视无张力理念：轴向预拉伸的弹性纳米纤维移植物在临床前模型中恢复动脉样轴向生物力学
Elizabeth Zermeno,Amanda Reke,Apurbo Kumar Paul et al.
Elizabeth Zermeno et al.
Healthy arteries function under substantial axial prestretch (AP), the ratio of in vivo to unloaded ex vivo length. Loss of AP promotes tortuosity and disturbed hemodynamics associated with vascular pathology, yet artery-like AP has not bee...
Multiscale analysis reveals distinct temporal trajectories of morphological reconstruction and mechanical maturation during mouse digit tip regeneration [0.03%]
多尺度分析揭示了小鼠数字尖端再生过程中形态重建和机械成熟的distinct temporal trajectories不同时间轨迹
Hanwen Fan,Preston Nguyen,Zerrin Uzum et al.
Hanwen Fan et al.
Mouse digit tip regeneration offers a model for mammalian epimorphic regeneration, yet the spatiotemporal evolution between emerging tissue architecture and its mechanical environments remain poorly understood. In this study, we employed a ...
Efferocytosis inhibition enhances the anticancer immune response of hybrid cell membrane-coated nanoparticles [0.03%]
抑制吞噬作用可增强杂化细胞膜包被纳米颗粒的抗癌免疫反应
Tao Huang,Zhibin Qiu,Xuewei Yang et al.
Tao Huang et al.
The immunogenic cell death (ICD) of tumor cells generates abundant damage-associated molecular patterns (DAMPs) to induce efficient anti-tumor immune responses. However, dysregulated efferocytosis causes rapid clearance of DAMPs, thereby im...