Tuning the Polyethylene Glycol-Lipid Anchor Length of Lipid Nanoparticles to Enhance Brain-Targeted siRNA Delivery [0.03%]
通过调整脂质纳米颗粒中的聚乙二醇-脂质锚链长度以增强siRNA向大脑的靶向递送
Haiyang Tong,Zesen Ma,Dongsheng Li et al.
Haiyang Tong et al.
The blood-brain barrier (BBB) remains a major challenge in the treatment of central nervous system (CNS) diseases. Lipid nanoparticles (LNPs) have emerged as promising carriers for small interfering RNA (siRNA) delivery to the brain. Howeve...
A multifunctional self-gelling hemostatic powder based on synergistic non-covalent interactions for rapid hemostasis and infected wound healing [0.03%]
一种基于非共价协同作用的多功能自凝止血粉用于快速止血和感染伤口愈合
Xiaohui Li,Minglun Cai,Jiawei Gao et al.
Xiaohui Li et al.
Rapidly controlling severe hemorrhage, especially from non-compressible wounds or under challenging physiological conditions, remains a critical clinical challenge often unmet by current hemostatic materials that are limited by insufficient...
Precision Therapeutics for Inflammatory Bowel Disease Using Engineered Probiotics:Strategies and Optimization [0.03%]
使用工程益生菌治疗炎症性肠病的精准药物学：策略与优化
Yutong Xue,Mingyang Hu,Sina Cha et al.
Yutong Xue et al.
The incidence of inflammatory bowel disease (IBD) has been increasing annually, evolving into a global health concern. Dysbiosis of the gut microbiota plays a crucial role in the pathogenesis of IBD. Probiotics, capable of modulating the gu...
Microfluidic Engineering of Microgels: Fabrication Methods, Structural Design, Assembly Strategies, and Biomedical Applications [0.03%]
微凝胶的微流体工程：制备方法、结构设计、组装策略及生物医学应用
Zhiyuan Sun,Jinsheng Zhou,Lianghe Sheng et al.
Zhiyuan Sun et al.
Microgels, valued for their superior hydrogel properties and large specific surface area, serve as microcarriers for drugs or cells in tissue engineering, demonstrating vast potential in biomedicine. Microfluidic technology currently enable...
Post-yield Behavior and Failure Mechanisms of Murine Cortical Bone at the Microscale across Different Ages Depend on Alterations in Mineralized Collagen Fibrils' Arrangement [0.03%]
小鼠皮质骨微尺度屈服后的失效机制受不同年龄段矿化胶原纤维排列变化的影响
Yiwei Hu,Fa Liu,Dongliang Lu et al.
Yiwei Hu et al.
Aging increases the incidence of clinical bone fractures. Mechanisms by which bones dissipate energy and prevent failure may change with age, potentially due to changes in physical and mechanical properties of components, as well as archite...
Sulfhydryl-modified nanocarriers enhance corneal retention and ocular anti-inflammatory efficacy in dry eye therapy [0.03%]
硫醇修饰的纳米载体可提高干眼病治疗中药物在角膜的滞留及抗炎效果
Tianzuo Wang,Huaidong Peng,Yunlong Gao et al.
Tianzuo Wang et al.
Despite great advances in nanomedicine for targeted drug delivery, the role of nanoparticle (NP) surface chemistry in optimizing ocular therapeutics remains underexplored. Here, we employ a library of DSPE-PEG polymeric nanocarriers functio...
Innovative Applications and Synergistic Strategies for Covalent Organic Frameworks in Multimodal Phototherapy [0.03%]
用于多模态光疗的共价有机框架的创新应用和协同策略
Huiming Chen,Jinpei Mei,Jie Chen et al.
Huiming Chen et al.
Over the past few decades, the field of phototherapy has undergone a significant transition. Covalent organic frameworks (COFs), with their structural design, biocompatibility, and photostability, have emerged as key materials in photothera...
Xianjin Zhang,Huafang Li
Xianjin Zhang
With the advancement of biomedical materials, biodegradable metals have demonstrated broad application prospects in fields such as orthopedic fixation and cardiovascular stents due to their appropriate mechanical properties, controllable de...
Advancing dermatology with skin equivalents and organoids in pathophysiology and drug testing [0.03%]
利用皮肤替代物和类器官在皮肤病生理学和药物检测中推进皮肤科研究
Bahar Lakeh,Abbas Shafiee
Bahar Lakeh
The progression of dermatologic models from simple two-dimensional cultures to advanced three-dimensional skin equivalents (SE) and skin organoids (SKO) has transformed skin research and therapy. This scoping review explores the evolution o...
Silk-based multilayer coatings for anticoagulation and durability improvement in ECMO hollow fiber membranes [0.03%]
基于蚕丝的多层涂层用于体外膜氧合中空纤维膜的抗凝和耐久性改进
Wenbo Zhang,Yilin Zhang,Chenlu Wang et al.
Wenbo Zhang et al.
In clinical extracorporeal membrane oxygenation (ECMO), prolonged blood residence time in oxygenators can lead to thrombus formation and complications. Heparin-based bioactive coatings are commonly used for anticoagulation, but prolonged sh...