Mechanics, Fracture, and Fragmentation of Thrombi: A Computational Study Review [0.03%]
血栓的力学、断裂和碎裂：一项计算研究综述
Beikang Gu,Kun Jiang,Taotao Wu et al.
Beikang Gu et al.
Thrombosis drives myocardial infarction, acute ischemic stroke and pulmonary embolism, yet more than half of patients undergoing mechanical thrombectomy fail to achieve functional independence, and residual thrombus is detected in up to 91%...
Inhalable Upper Critical Solution Temperature-type Polymer Nanoparticles with Gradient Spatial Protonation and Thermal Expansion Across Physiological Multibarriers [0.03%]
具有空间梯度质子化和生理多屏障温控膨胀效应的可吸入临界溶液温度型聚合物纳米颗粒
Jie Qiao,Jiaxin Zeng,Hongzhao Jiang et al.
Jie Qiao et al.
Inhalable nanodelivery faces a tricky and paradoxical interfacial challenge: penetrating mucus requires nanoparticles to be negatively charged or neutral to avoid electrostatic trapping, whereas targeting and disrupting bacterial biofilms s...
Engineering Spatially Organized Hair Peg-like Structures in Human Skin Constructs Using Keratinocyte-Dermal Papilla Fibroblast Spheroids and Micropatterned Dermal Scaffolds [0.03%]
利用角质形成细胞-毛乳头成纤维细胞球体和微图案真皮支架工程化人类皮肤结构中的空间有序毛囊状结构
Lindsey G Siegfried,Linli Zhou,Jie Wang et al.
Lindsey G Siegfried et al.
Tissue-engineered skin substitutes (TESS) represent a key therapeutic option for extensive cutaneous injuries when autologous grafting is limited; however, current constructs lack skin appendages, particularly hair follicles, resulting in i...
Zinc-enriched Pathological Biominerals in the Human Kidney Encode their Anatomical Microenvironments [0.03%]
人体肾脏病理生物矿中富含锌元素并记录其解剖微环境信息
Sudarshan Srirangapatanam,Benjamin Greenfield,Jorge Mena et al.
Sudarshan Srirangapatanam et al.
The fundamental mechanisms underlying kidney stone formation remain elusive despite extensive research, limiting prevention strategies and contributing to high recurrence rates. Traditionally understood to arise through systemic urine super...
Zwitterionic Tissue Expanders Reduce Infection and Fibrosis for Enhanced Biocompatibility [0.03%]
两性离子组织扩张器可减少感染和纤维化以增强生物相容性
Stephanie L Fung,Matthew R Aronson,William R Katowitz et al.
Stephanie L Fung et al.
Current osmotic tissue expanders suffer from protein adsorption, bacterial colonization, and excessive fibrotic encapsulation that compromise device performance. In this study, we synthesized zwitterionic hydrogels using methyl methacrylate...
3D printing in ophthalmology: From basic research to clinical transformation [0.03%]
眼科的三维打印技术：从基础研究到临床转化
Zhuotong Wu,Yong Ma,Liyin Wang et al.
Zhuotong Wu et al.
3D printing is reshaping ophthalmic biomaterials, tissue models, implants, biosensors, and drug-delivery systems, but its clinical value depends on matching each printing strategy to ocular-specific requirements rather than on printing capa...
Targeting the mechanics-glycolysis-histone lactylation axis to rescue bone regeneration under insufficient mechanical stimulation [0.03%]
靶向力学-糖酵解-组蛋白乳酸化轴以拯救机械刺激不足条件下的骨再生
Qiyuan Yang,Yandi Chen,Yumeng Wu et al.
Qiyuan Yang et al.
Mechanical signals are essential for bone homeostasis and regeneration. Reduced mechanical stimulation, such as that occurring during fractures, paralysis, or aging, leads to bone loss and impaired osseous repair. However, effective clinica...
Supramolecular Recognition-Based Hydrogels Incorporating Vascular Endothelial Growth Factor and Hesperadin for Infarcted Myocardial Repair and Angiogenesis [0.03%]
基于超分子识别的含血管内皮生长因子和hesperadin水凝胶的心肌修复及促血管新生作用
Kaiyi Zhu,Qian Yang,Xiang Guo et al.
Kaiyi Zhu et al.
Myocardial infarction (MI) induces pathological remodeling that drives heart failure. Dual-targeted approaches addressing myocardial repair and angiogenesis are crucial for improving post-infarct prognosis. Previous research has demonstrate...
Improved localization to sites of hemorrhage via peptide amphiphile nanofibers containing a factor VII-mimetic epitope [0.03%]
含 VII 因子模拟表位的肽两亲分子纳米纤维改善出血部位定位
Trevor P Stone Jr,Sophia L Maragos,James D Greenwood et al.
Trevor P Stone Jr et al.
Hemorrhage is a leading cause of potentially preventable deaths in pre-hospital settings. Hence, there is a great need to develop a therapeutic that can be administered in the field to slow or stop hemorrhage before definitive treatment can...
Identification of In Vivo Constitutive Parameters of Thoracic Aortic Aneurysms Based on the Unified-Fiber-Distribution Model [0.03%]
基于统一纤维分布模型的胸主动脉瘤在体固有参数识别研究
Xue Liang,Tianyu Wang,Wenbin Mao et al.
Xue Liang et al.
Accurate patient-specific aortic-wall constitutive parameters are essential for biomechanical risk assessment of thoracic aortic aneurysms (TAA), yet their non-invasive determination remains challenging. Here, we proposed an inverse finite ...