A pH-responsive hyaluronic acid hydrogel facilitates lesion-localized integrin α5β1 agonism to attenuate osteopontin signaling and fibrosis in intrauterine adhesions [0.03%]
一种pH响应性透明质酸水凝胶通过激活整合素α5β1来调节宫腔粘连微环境中的osteopontin信号通路及纤维化反应
Wanqing Ji,Jiaming Wen,Nian Tong et al.
Wanqing Ji et al.
Intrauterine adhesion (IUA) features persistent immune-stromal disequilibrium and excessive fibrosis driven by inflammatory macrophages, yet current interventions fail to resolve this dysregulation. We developed an in situ-administered pH-r...
Dual Crosslinked Thermosensitive Hydrogel Engineered with Multiple Dynamic Hydrogen Bonds for Enhanced Photodynamic Antibacterial Activity and Wound Healing [0.03%]
利用多重动态氢键工程化双交联热敏水凝胶增强光动力抗菌活性和伤口愈合性能
Peipei Xu,Jingnan Xiong,Baijie Cheng et al.
Peipei Xu et al.
To address the challenges posed by bacterial infection and the persistent oxidative microenvironment in diabetic wounds, a multifunctional intelligent hydrogel dressing (SPC) was developed, comprising sodium alginate (SA) , poly (N-isopropy...
Erratum to "Emerging Cell-Free DNA Scavenging Biomaterials for Inflammatory Diseases: From Mechanisms to Therapies" [Acta Biomaterialia 204 (2025) 1-29] [0.03%]
关于“用于炎症性疾病的新出现的细胞-freeDNA清除生物材料：从机制到治疗”一文的勘误[Acta Biomaterialia 204 (2025) 1-29]
Lijuan Xie,Chenxin Lu,Haitao Wu et al.
Lijuan Xie et al.
Published Erratum
Acta biomaterialia. 2026 Mar 1:S1742-7061(26)00130-3. DOI:10.1016/j.actbio.2026.02.046 2026
White Light-Triggered Cascade NO/ROS-Releasing Platform with Synergistic Antibacterial and Angiogenic Effects for Infected Wound Healing [0.03%]
具有协同抗菌和促血管生成作用的白光触发级联一氧化氮/活性氧释放平台促进感染伤口愈合
Shanmin Tao,Miao Yang,Shijie Fu et al.
Shanmin Tao et al.
Effective treatment of infected wounds requires concurrent control of microbes and restoration of vascular supply. Conventional therapies, including antibiotics and growth factors, suffer from limited efficacy and stability. Nitric oxide (N...
Cell-Targeted Nanocomplex Facilitates Direct Reprogramming of Astrocytes into Dopaminergic Neurons in Parkinson's Disease [0.03%]
细胞靶向纳米复合物可促进帕金森病 astrocyte 重新编程为多巴胺能神经元
Yerim Hwang,Neethu Ramakrishnan,Junyeop Kim et al.
Yerim Hwang et al.
Direct in vivo reprogramming of dopaminergic neurons represents a transformative approach for neuroregeneration, enabling the generation of new functional dopamine neurons in the brain and offering direct therapeutic potential for Parkinson...
Valve endothelial monolayer fissuring and interstitial matrix fracture triggers calcific lesion formation via GTPase signaling [0.03%]
阀内皮单层裂解和细胞外基质断裂通过GTP酶信号触发钙化病变形成
Katherine Driscoll,Santosh Balakrishnan,G Janani et al.
Katherine Driscoll et al.
Calcific aortic valve disease (CAVD) is a degenerative disease with wide prevalence in the aging population and a low survival rate after onset of symptoms, yet there are no effective pharmacological treatments. Many patients present to the...
Recapitulating Patient-to-Patient Colorectal Cancer Tumor Heterogeneity Using Patient-Derived Xenograft Cells in an Engineered Tissue Model [0.03%]
利用工程组织模型中的患者来源异种移植细胞重现患者间结直肠肿瘤的异质性
Iman Hassani,Benjamin Anbiah,Yuan Tian et al.
Iman Hassani et al.
Establishing in vitro cancer models that more closely recapitulate patient tumor microenvironmental heterogeneity, including variations in stromal cells and mechanical properties that influence colorectal cancer (CRC) progression, is crucia...
Peptide Concentration Gradients and Aligned Microfiber Topography Synergize to Speed and Direct Schwann Cell Migration [0.03%]
肽浓度梯度和排列整齐的微纤维拓扑结构协同作用加速并指引施万细胞迁移
Yin Mei Chan,Yang Hu,Nicola G Judge et al.
Yin Mei Chan et al.
Conjugating precise concentrations of bioactive peptides on aligned topographies holds a promising application in directionally guiding Schwann cell migration, a significant step in peripheral nerve regeneration. To harness this behavior, w...
Potential of Intranasal Delivery of Human Mesenchymal Stem Cells and Extracellular Vesicles for Stroke Therapy [0.03%]
人骨髓间充质干细胞和外泌体经鼻递送治疗卒中的潜能
Arshia Arbabian,Tristan Driscoll,Yan Li et al.
Arshia Arbabian et al.
Cerebral ischemic stroke, caused by interrupted cerebral blood flow, remains a leading cause of mortality and long-term disability worldwide. Current FDA-approved therapies-intravenous tissue-type plasminogen activator (tPA) and mechanical ...
Biomaterial-based strategies for neural modulation in innervated bone regeneration [0.03%]
基于生物材料的神经调节在神经支配性骨再生中的策略
Bin Wang,Zhuozhen Li,Hanyu Jiang et al.
Bin Wang et al.
The nervous system plays a pivotal role in regulating skeletal homeostasis and bone regeneration. However, neural modulation and innervation reconstruction during bone healing have long been underestimated in conventional bone repair strate...