Nose-to-brain delivery of a SOD1-stabilizing small molecule ameliorates pathology in an ALS mouse model [0.03%]
一种稳定SOD1的小分子鼻脑递送改善ALS小鼠模型病理学症状
Ranjithkumar Dhandapani,Shamchal Bakavayev,Anna Armoza et al.
Ranjithkumar Dhandapani et al.
Exposure of a pathogenic β6/β7 loop neo-epitope has been proposed to contribute to the pathogenesis of misfolded Cu/Zn superoxide dismutase (SOD1) in amyotrophic lateral sclerosis (ALS) by mediating early events in its noxious structural ...
Restoring Theta-Gamma coupling in Alzheimer's disease: Toward network-based neuromodulation [0.03%]
阿尔茨海默病的 theta- gamma 同步性恢复：面向网络的神经调控疗法研究
Shixie Jiang
Shixie Jiang
Identification of vital sign trajectory phenotypes and treatment response heterogeneity in critically ill patients with ischemic stroke: A multicenter study with external validation [0.03%]
重症缺血性卒中患者生命体征轨迹表型及治疗反应异质性的识别：一项多中心研究及其外部验证
Lijuan Wang,Duozi Wang,Bo Tang et al.
Lijuan Wang et al.
Critically ill patients with ischemic stroke exhibit heterogeneous hemodynamic patterns, yet previous trajectory-based studies have focused on single vital sign parameters. We conducted a multicenter retrospective cohort study to identify v...
Nervonic acid supplementation mitigates disease severity biomarkers in adrenoleukodystrophy [0.03%]
神经醇酸补充可缓解肾上腺脑白质营养不良的病情严重生物标志物水平
Chenxu Li,Kai Braaten,Ann B Moser et al.
Chenxu Li et al.
X-linked adrenoleukodystrophy (ALD) is a severe neurometabolic disorder caused by mutations in the ABCD1 gene, leading to impaired peroxisomal β-oxidation of very long-chain fatty acids (VLCFAs). The accumulation of saturated VLCFAs, predo...
Chicoric acid enhanced brain cholesterol efflux and reduced Aβ pathology via LXR-ABCA1 signaling in Alzheimer's models [0.03%]
胆烃酸通过LXR-ABCA1信号通路增强阿尔茨海默病模型中胆固醇流出并降低Aβ病理水平
Daiyue Li,Yu Zhang,Ruonan Wang et al.
Daiyue Li et al.
Alzheimer's disease (AD) is one of the most pressing public health challenges in an aging world. However, effective therapeutic strategies are still lacking. Imbalance in lipid homeostasis is a key driver of AD. Given the established link b...
Arginine ameliorates motor and survival deficits in MFN2-Deficient Drosophila models [0.03%]
精氨减轻MFN2缺陷的果蝇模型中的运动和存活缺陷
Masahiro Ando,Yuji Okamoto,Yujiro Higuchi et al.
Masahiro Ando et al.
Charcot-Marie-Tooth disease type 2 A (CMT2A) is an inherited axonal neuropathy linked to mutations in MFN2, a key regulator of mitochondrial dynamics. Currently, no effective drug therapies exist. l-arginine has shown promise in treating mi...
Feasibility and safety of vertebrobasilar artery cooling infusion (VACI) following thrombectomy for acute posterior circulation ischemic stroke: A pilot randomized controlled trial [0.03%]
急性后循环缺血性卒中取栓术后血管内选择性亚低温治疗可行性及安全性：一项前瞻性随机对照试验
Zhe Cheng,Yuchuan Ding,Gary Rajah et al.
Zhe Cheng et al.
Not all patients with acute ischemic stroke (AIS) benefit from endovascular therapy (EVT), particularly in the posterior circulation. This pilot randomized controlled trial evaluated the safety, feasibility, and preliminary efficacy of vert...
Intermittent theta-burst stimulation to enhance physical therapy in Parkinson's disease: The STEP-PD randomized trial [0.03%]
间歇θ爆发刺激增强帕金森病物理治疗的疗效：STEP-PD随机试验
Hong-Yu Zhang,Ting-Ting Hou,Ke-Ke Chen et al.
Hong-Yu Zhang et al.
Physical therapy (PT) is commonly used to alleviate specific symptoms of Parkinson's disease (PD). Its efficacy may be enhanced by cortical priming, which aims to improve the brain's responsiveness to rehabilitation. This randomized, double...
Microglial lipid metabolism and epigenetic regulation: Emerging targets for spinal cord injury therapy [0.03%]
少突胶质细胞脂代谢及表观遗传调控：脊髓损伤治疗的新靶点
Nicolas Guérout
Nicolas Guérout