Letter from the Editor-in-Chief: Neurotherapeutics as a gold open access journal [0.03%]
主编来信：神经治疗学作为金色开放获取期刊
M Maral Mouradian
M Maral Mouradian
Engineered nanoplatforms for brain-targeted co-delivery of phytochemicals in Alzheimer's disease: Rational design, blood-brain barrier penetration, and multi-target therapeutic synergy [0.03%]
阿尔茨海默病脑靶向输送植物化学物的纳米平台：合理设计、血脑屏障渗透及多靶标协同治疗效应
Lianghong Chen,Yadi Guan,Shaojun Wang et al.
Lianghong Chen et al.
Alzheimer's disease (AD) presents significant therapeutic challenges due to its multifactorial pathology, the inefficacy of traditional single-target drugs, and the poor bioavailability and limited blood-brain barrier (BBB) penetration of p...
Procedure time and outcomes in acute ischemic stroke with anterior circulation large vessel occlusion in the early and late time windows: A stratified analysis by onset-to-puncture time [0.03%]
缺血性卒中前循环大血管闭塞早晚期急诊取栓的时间和疗效：按发病至穿刺时间分层分析
Kangjia Song,Shuang Qi,Chao Li et al.
Kangjia Song et al.
Previous studies have suggested that procedure time (PT) is associated with prognosis in patients undergoing endovascular treatment (EVT). However, its relationship with prognosis in different time windows remains unclear. This study aimed ...
Shared and unique therapeutic targets of KarXT and clozapine for schizophrenia treatment revealed by network pharmacology and molecular docking analyses: Implications for differential clinical responses [0.03%]
网络药理学和分子对接分析揭示KarXT和氯氮平治疗精神分裂症的共有和特异性靶点：对不同临床反应的意义
Chuanjun Zhuo,Chao Li,Hongjun Tian et al.
Chuanjun Zhuo et al.
Xanomeline plus trospium (KarXT) is a combination drug targeting muscarinic receptors with demonstrated efficacy against positive, negative, and cognitive symptoms of schizophrenia, although therapeutic effects on positive and negative symp...
Sertraline treatment prevents motor dysfunction in a Huntington's disease mouse model and functional decline in patients [0.03%]
盐酸舍曲林治疗亨廷顿舞蹈病小鼠模型的运动障碍并改善患者的临床功能减退症状
Marta Garcia-Forn,Carla Castany-Pladevall,Jordi Creus-Muncunill et al.
Marta Garcia-Forn et al.
Molecular alterations underlying Huntington's disease (HD) are not fully elucidated and no curative therapies are available. We have described that increased translation efficiency participates in the motor symptoms in the R6/1 HD mouse mod...
Hideo Kimura
Hideo Kimura
Hydrogen sulfide (H2S) and polysulfides including H2Sn (n = 2 or more) regulate neuronal activity, vascular tone, oxytosis/ferroptosis, oxygen sensing, cancer growth and senescence. Cystathionine β-synthase (CBS), cystathionine γ-lyase ...
Reticuline modulates astrocyte and microglial responses to enhance prognosis after traumatic brain injury [0.03%]
脑外伤后网iline通过调节星形胶质细胞和小胶质细胞反应以改善预后
Shuhui Xu,Jue Zhu,Jiajia Wen et al.
Shuhui Xu et al.
Traumatic brain injury (TBI) poses a serious threat to public health due to its high disability and mortality rates. Therefore, it is crucial to explore effective therapeutic strategies. Studies have shown that reticuline may exert a cardio...
Montelukast alleviates neuroinflammation and improves motor functions in the line 61 model of Parkinson's disease: An exploratory study [0.03%]
蒙特鲁卡斯特减轻线61型帕金森病模型的神经炎症并改善运动功能：一项探索性研究
Katharina Strempfl,Marco Zattoni,Heike Mrowetz et al.
Katharina Strempfl et al.
Parkinson's disease (PD) is a neurodegenerative movement disorder of high global burden. Uncertainties regarding its exact etiology have been hindering the development of curative therapies. As microglia, the brain's immune cells, are suspe...
From metabolism to mind: The expanding role of the GLP-1 receptor in neurotherapeutics [0.03%]
从代谢到精神：GLP-1受体在神经治疗中的作用日益扩大
Akash Roy,Valina L Dawson,Ted M Dawson
Akash Roy
GLP-1 receptor agonists (GLP-1RAs), initially approved for diabetes and obesity, are now under investigation for neuroprotective effects in a range of neurological disorders. These agents, whose receptors are widely expressed in brain regio...
Preoperative network activity predicts the response to subthalamic DBS for Parkinson's disease [0.03%]
术前网络活动可预测帕金森病丘脑底核DBS的治疗反应
Prashin Unadkat,An Vo,Yilong Ma et al.
Prashin Unadkat et al.
Quantitative imaging markers to aid in the selection of Parkinson's disease (PD) patients for surgical interventions such as subthalamic nucleus deep brain stimulation (STN-DBS) are currently lacking. Using metabolic PET and network analysi...