Black gas, bright future: H2S based therapeutics for neurodegenerative disorders [0.03%]
化弊为利：H2S 基药物治疗神经退行性疾病
Jordan L Morris,Jordan J Lee,Russell E Morris et al.
Jordan L Morris et al.
From shaping Earth's earliest anoxic seas to quietly orchestrating cellular life today, hydrogen sulfide (H2S) has journeyed from ancient toxin to modern therapeutic candidate. Once abundant in Earth's primordial environment, H2S has reemer...
Nanoparticle and epothilone D combinatorial intervention improves motor performance and regeneration in chronic cervical spinal cord injury [0.03%]
纳米颗粒和epothilone D联合干预可改善慢性颈椎脊髓损伤的运动功能及促进修复反应
Sarah E Hocevar,Brian C Ross,Samantha R Schwartz et al.
Sarah E Hocevar et al.
Spinal cord injury (SCI) causes the loss of motor function below the site of injury due to neuron loss and the severing of spinal tracts. The injury leads to the recruitment of circulating myeloid cells that create an inflammatory microenvi...
Pleiotropic regulatory mechanisms and targeted therapeutic prospects of Galectin-3 in aging-related diseases [0.03%]
糖连结素-3在衰老相关疾病中的多效性调控机制及靶向治疗前景
Jiayu Yuan,Xiaoyu Dong,Yan Gao et al.
Jiayu Yuan et al.
Aging is a major risk factor for numerous chronic diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), atherosclerosis (AS), type 2 diabetes mellitus (T2DM), osteoarthritis (OA) and age-related macular degeneration (AMD)....
Neuroprotective role of DNTαβ Cell transplantation on modulating immune microenvironment in spinal cord injured mice [0.03%]
DNTαβ细胞移植在脊髓损伤小鼠中调节免疫微环境的神经保护作用
Yingli Jing,Zihan Li,Fan Bai et al.
Yingli Jing et al.
Traumatic spinal cord injury (SCI) is a common disabling condition characterized by a disrupted immune microenvironment that significantly hinders neural regeneration. In recent years, CD3+CD4-CD8- double-negative T cells (DNT cells) have g...
Neurocognitive and neurobiological effects of low dose organophosphate exposure [0.03%]
低剂量有机磷暴露对神经认知和神经生物学的影响
Kelly M C Nguyen,Devyani Swami,Nandini Goyal et al.
Kelly M C Nguyen et al.
Organophosphates (OPs) have been used as nerve agents in the Persian Gulf Wars and terrorist attacks in Japan and the United Kingdom. While high doses of OPs may be lethal, lower dose OP exposures can lead to neurotoxic consequences for the...
TNFR2 signaling shapes the sex-specific remyelinating properties of microglia after experimental stroke [0.03%]
TNFR2信号通路塑造了实验性卒中后小胶质细胞的性别特异性重塑髓鞘的能力
Stefano Raffaele,Francesca Carolina Mannella,Estrid Thougaard et al.
Stefano Raffaele et al.
Microglial tumor necrosis factor receptor 2 (TNFR2) has emerged as a critical modulator of neuroinflammation and repair following ischemic stroke. Here, we investigated the sex-specific role of TNFR2 in regulating microglial responses durin...
Rescue of neurologic disease in mucopolysaccharidosis type II mice via AAV-mediated liver delivery of brain-penetrating iduronate-2-sulfatase [0.03%]
AAV介导的脑渗透型黏多糖硫酸酯(iduronate-2-sulfatase)肝脏递送治疗II型黏多糖贮积症小鼠神经系统病变研究
Xiu Jin,Qin Ye,Xiaoyi Wu et al.
Xiu Jin et al.
Mucopolysaccharidosis type II (MPS II) is a neurodegenerative lysosomal storage disorder (LSD) caused by inherited mutations in the iduronate-2-sulfatase (IDS) gene. Approximately two-thirds of patients exhibit severe central nervous system...
Neural bridging achieves transcutaneous regulation of vagus nerve function and treatment of depressive disorders [0.03%]
神经桥接实现迷走神经的透皮调节及抑郁症治疗
Fengchi Sun,Xiangmeng Su,Yiyuan Wang et al.
Fengchi Sun et al.
Vagus nerve stimulation (VNS) represents a neuromodulation technique that has shown potential in the treatment of various diseases. However, conventional VNS therapy is constrained by the requirement for implanted electrodes, primarily due ...
CRISPR-edited iPSCs reveal BSN gene mutations induce neuronal hyperexcitability via astrocyte lipid accumulation [0.03%]
crispr编辑的诱导多能干细胞揭示了BSN基因突变通过星形胶质细胞脂质积累诱发神经元过度兴奋
Haiying Chen,Shanshan Fan,Kanglian Chen et al.
Haiying Chen et al.
Mutations in the BSN gene, encoding the presynaptic protein Bassoon, are implicated in epilepsy, but their impact on astrocytes remains unclear. Using CRISPR/Cas9, we introduced patient-derived BSN mutations (p.M1903V and c.5672insCG) into ...
Real-world effectiveness and safety of ofatumumab in relapsing-remitting multiple sclerosis: Insights from naïve and switch patients [0.03%]
奥法木单抗在复发型多发性硬化症患者中的有效性和安全性：初治和转治患者的启示
Clara G Chisari,Salvatore Lo Fermo,Salvatore Iacono et al.
Clara G Chisari et al.
Ofatumumab (OFA), a fully human anti-CD20 monoclonal antibody, has shown promising efficacy in treating relapsing multiple sclerosis (RMS) by depleting B cells and reducing disease activity. This real-world, prospective, multicenter study e...