Effects of fasudil on disease spreading in ALS - A MUNIX-based post-hoc analysis of the ROCK-ALS trial [0.03%]
Fasudil对ALS疾病进展的影响——ROCK-ALS试验的MUNIX事后分析
Andreas W Wolff,Andreas Leha,Jan C Koch et al.
Andreas W Wolff et al.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the spread of muscle weakness across body regions. ROCK-ALS was a multicenter, placebo-controlled phase 2 trial assessing the safety, tolerabili...
Electric muscle stimulation attenuates neuroinflammation and improves the outcome of acute ischemic stroke in mice [0.03%]
电肌肉刺激可减轻急性脑卒中小鼠的神经炎症并改善预后
Anna Törteli,Péter Kozák,Hiroyuki Uno et al.
Anna Törteli et al.
Acute ischemic stroke is a major cause of death and disability, yet many patients cannot engage in early rehabilitation due to severe motor deficits. Resulting immobility accelerates muscle atrophy and systemic inflammation, highlighting mu...
Clinical trials of surgical neuromodulation therapies for epilepsy: Past, present & future [0.03%]
癫痫的外科神经调控治疗临床试验：过去、现在与未来
Rory J Piper,Martin M Tisdall
Rory J Piper
Neuromodulation is expanding as an avenue of therapy for patients with either focal- or generalized-onset epilepsy. Current implantable surgical options include deep brain stimulation (DBS), responsive neurostimulation (RNS®; NeuroPace), v...
Safety profile and potential clinical risks of xanomeline and trospium chloride: A real-world pharmacovigilance study using FAERS [0.03%]
基于FAERS的XANOMELINE和TROSPİUM CHLORIDE安全性特征及潜在临床风险的药物流行病学研究
Zhuocheng Bao,Yakun Liu,Yuxiang Liu
Zhuocheng Bao
Xanomeline and trospium chloride, the first FDA-approved oral cholinergic therapy for adults with schizophrenia in decades, represents a mechanistic shift in antipsychotic treatment, yet its real-world safety profile remains incompletely de...
P R Holland,P J Goadsby
P R Holland
Rad23b exacerbates pathological aggregates through disrupting proteasome functions in Spinocerebellar ataxia type 3 [0.03%]
Rad23b通过破坏蛋白酶体功能加剧脊髓小脑共济失调3型病理聚集体形成
Yi-Ching Chen,Chih-Wei Tung,Siew Chin Chan et al.
Yi-Ching Chen et al.
Spinocerebellar ataxia type 3 (SCA3) is the most common autosomal dominant ataxia globally, caused by expanded CAG repeats in the ATXN3 gene and consequent pathogenic accumulation of mutant ATXN3 (mATXN3) aggregates. The formation of these ...
Impact of time from symptom onset to recanalization in acute anterior circulation large vessel occlusive stroke with same tissue window: A patient-level pooled analysis of the three randomized controlled trials [0.03%]
发病至再通时间对急性大血管闭塞且相同组织窗的前循环卒中患者的影响：一项随机对照研究的患者级汇总分析
Xiang Liu,Gaoming Li,Zhaokun Li et al.
Xiang Liu et al.
Although multimodal imaging extends the thrombectomy window to 24 h based on tissue viability, the prognostic value of shorter onset-to-recanalization times within this window is unclear. Using pooled trial data, we assessed this associatio...
Heterogeneous brain alterations in treatment-resistant depression converge on common control networks [0.03%]
治疗抵抗性抑郁症的异质性脑改变集中在共同的控制网络上
Yiding Han,Haohao Yan,Wenbin Guo et al.
Yiding Han et al.
Treatment-resistant depression (TRD) imposes a substantial clinical and societal burden. However, it remains unclear whether neuroimaging abnormalities associated with TRD converge onto specific large-scale brain networks. We systematically...
Regulation of microglial activation by progranulin through the NF-κB pathway in subarachnoid hemorrhage and its effect on white matter injury [0.03%]
通过NF-κB途径调节血浆素原在蛛网膜下腔出血后的小胶质细胞活化及其对白质损伤的影响
Ziliang Hu,Pan Lv,Wenting Lan et al.
Ziliang Hu et al.
Subarachnoid hemorrhage (SAH) is a severe cerebrovascular condition commonly associated with white matter injury and subsequent cognitive dysfunction. Emerging evidence suggests that progranulin (PGRN) is involved in neuroinflammation regul...