Rad23b exacerbates pathological aggregates through disrupting proteasome functions in Spinocerebellar ataxia type 3
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Spinocerebellar ataxia type 3 (SCA3) is the most common autosomal dominant ataxia globally, caused by expanded CAG repeats in the ATXN3 gene and consequent pathogenic accumulation of mutant ATXN3 (mATXN3) aggregates. The formation of these aggregates perturbs ... ...
