CSF1R and IL1R1 inhibitors synergistically attenuate the early pathogenesis of traumatic brain injury in mice [0.03%]
小鼠脑外伤早期病理改变的协同阻抑剂研究： CSF1R和IL1R1抑制剂的作用
Sudena Wang,Yong Wang,Jenny Strehle et al.
Sudena Wang et al.
There is an unmet need in the treatment of traumatic brain injury (TBI), a leading cause of death and disability. Colony stimulating factor 1 receptor (CSF1R) and interleukin 1 receptor type 1 (IL1R1) are critical regulators of TBI-associat...
Salidroside ameliorates experimental autoimmune neuritis by dually modulating neuroinflammation and immune homeostasis via PI3K/AKT signaling [0.03%]
红景天苷通过PI3K / AKT信号转导双重调节神经炎症和免疫稳态来改善实验性自身免疫性神经炎
Tao Gu,Li Wang,Xue Kang et al.
Tao Gu et al.
Guillain-Barré syndrome (GBS), an acute autoimmune peripheral neuritis, remains a clinical challenge due to limited therapeutic efficacy and heterogeneous patient responses. The present study investigated salidroside (SAL), a bioactive phe...
Delayed necrostatin-1s infusion attenuates cystic white matter injury in preterm fetal sheep [0.03%]
延迟注射Necrostatin-1s减轻早产胎儿绵羊的囊状白质损伤
Benjamin A Lear,Christopher A Lear,Simerdeep K Dhillon et al.
Benjamin A Lear et al.
Severe, cystic white matter injury (WMI) in preterm infants is associated with neurodevelopmental impairment. Strikingly, it often develops weeks after birth. In the present study we tested the hypothesis that necrotic programmed cell death...
Targeting NAAG metabolism restores cognition and synaptic integrity in EcoHIV-infected mice [0.03%]
靶向NAAG代谢可改善EcoHIV感染小鼠的认知和突触完整性
Yuxin Zheng,Meixiang Huang,R Michael Maragakis et al.
Yuxin Zheng et al.
Despite effective antiretroviral therapy, many people living with HIV (PLH) experience cognitive impairments, particularly in executive function and working memory. These deficits have been linked to dysregulation of brain circuits involvin...
Restoration neurite growth by removing the blockage of endosome trafficking in Alzheimer-like mice [0.03%]
通过去除类似阿尔茨海默病小鼠的内体转运阻滞来恢复神经突生长
Huimin Zhao,Fangjie Li,Sheng Xu et al.
Huimin Zhao et al.
Synaptic loss is strongly associated with cognitive decline in Alzheimer's disease (AD). Endosomal trafficking dysfunction, observed in AD brains, impairs neurite growth. Because endosomal trafficking is essential for synaptic development, ...
Exidavnemab binds to aggregated α-synuclein in human brains affected by α-synucleinopathies [0.03%]
Exidavnemab结合α突触核蛋白病患者人脑中的聚集α-突触核蛋白
Olof Zachrisson,Malin Johannesson,Linda Söderberg et al.
Olof Zachrisson et al.
Abnormal accumulation of α-synuclein in neuronal and/or glial cells occurs in a range of neurodegenerative conditions, including Parkinson's disease, Parkinson's disease dementia, dementia with Lewy bodies, and multiple system atrophy. Imm...
Transcranial near-infrared therapy restores synaptic resilience by reshaping signaling landscapes in sleep-deprived tauopathy [0.03%]
经颅近红外疗法通过重塑tau病睡眠剥夺中的信号通量恢复突触韧性
Yue Dong,Sheng Wang,Xiaoyun Liu et al.
Yue Dong et al.
Chronic sleep deprivation (SD) is a prevalent and modifiable risk factor that accelerates neurodegeneration and exacerbates cognitive decline in Alzheimer's disease (AD). Here, we demonstrate that 808 nm transcranial near-infrared (tNIR) ...
Novel neurotherapeutic targets for substance use disorders: Neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems [0.03%]
物质使用障碍的新型神经治疗靶点：神经可塑性、神经炎症、气体信号分子及非经典器官系统
Papori Sharma,M Farris Sawaya,Alexandru Mihai Dumitrescu et al.
Papori Sharma et al.
Substance use disorders (SUDs) are chronic disorders marked by intense and compulsive drug-seeking behavior, coupled with a high risk of relapse. Different theories have emerged over time regarding mechanisms that induce and exacerbate SUDs...
Paired associative stimulation improves outcomes when applied at the subacute stage after incomplete cervical spinal cord injury [0.03%]
脊髓损伤亚急性期进行配对联想刺激可改善预后
Anastasia Shulga,Anna Nätkynmäki,Anna-Lena Pelkonen et al.
Anastasia Shulga et al.
We conducted a randomized sham-controlled clinical trial from 2019 to 2024 to characterize the safety and efficacy of applying paired-associative stimulation (PAS), consisting of high-intensity transcranial magnetic stimulation and high-fre...
Sigma-1-targeting multimodal compound HBK-15 reverses memory deficits and restores hippocampal plasticity under NMDA hypofunction [0.03%]
sigma-1受体激动剂HBK-15改善NMDA功能低下的学习记忆缺损及海马可塑性异常
Kinga Sałaciak,Klaudia Lustyk,Angelika Jagielska et al.
Kinga Sałaciak et al.
Memory impairment is among the most disabling features of depression and schizophrenia, yet remains largely untreated by available pharmacotherapies. NMDA receptor hypofunction is strongly implicated in these deficits, while sigma-1 recepto...