Corticothalamic loops and cellular networks: Implications for thalamic neuromodulation in epilepsy [0.03%]
皮质丘脑环路和细胞网络：癫痫丘脑神经调制的启示
Edward M Merricks,Hunki Kwon,Phoebe Wang et al.
Edward M Merricks et al.
Thalamic neuromodulation has emerged as a promising therapy to reduce seizures in patients with drug-resistant epilepsy who are not candidates for resective or ablative surgical treatments. This advance creates therapeutic opportunities for...
Honokiol attenuates neuroinflammation and enhances remyelination in mouse models of multiple sclerosis through PPARγ-mediated ERK/AKT signalling [0.03%]
淫羊藿素通过PPARγ介导的ERK/Akt信号途径缓解小鼠多发性硬化模型的神经炎症和促进脱髓鞘修复
Xueli Yu,Long Wei,Yanghao Zheng et al.
Xueli Yu et al.
Multiple sclerosis is characterized by inflammatory demyelination and insufficient myelin repair, which together drive progressive neurological impairment. While existing immunomodulatory treatments have demonstrated efficacy in reducing ac...
IL7R depletion mitigates neuroinflammation and ischemic stroke via AKT dephosphorylation dependent LCP1 suppression in mice [0.03%]
通过IL7R耗竭依赖的LCP1抑制在小鼠中缓解神经炎症和缺血性脑卒中的AKT去磷酸化作用
Qianqian Yin,Shaomeng Chen,Decao Yang et al.
Qianqian Yin et al.
Stroke remains a leading cause of death and long-term disability worldwide. After reperfusion following ischemic stroke, peripheral immune cells infiltrate the injured brain hemisphere and exacerbate secondary damage. Among these cells, mon...
Small proline-rich repeat protein 1A-mediated ephrin-A5 downregulation drives neuropathic pain via brain-derived neurotrophic factor/Tropomyosin receptor kinase B signaling [0.03%]
小脯氨酸丰富重复蛋白1A介导的Ephrin-A5下调通过脑源性神经营养因子/肌球蛋白受体激酶B信号驱动神经病理性疼痛
Meiling Deng,Ting Zhang,Jie Yang et al.
Meiling Deng et al.
Neuropathic pain is a common chronic pain condition that severely impacts patients' quality of life. While Small proline-rich protein 1A (SPRR1A) is a well-known marker for axonal regeneration, its specific role and the underlying molecular...
FRRS1L gene replacement ameliorates disease phenotypes in the mouse model of developmental and epileptic encephalopathy 37 [0.03%]
FRRS1L基因替代可改善发育性和癫痫性脑病37小鼠模型的表型
Mehrnaz Sheibani,Esther O Alao,Ummay Mariam et al.
Mehrnaz Sheibani et al.
Gene therapy offers unique therapeutic potential for treating rare genetic disorders such as DEE37, a severe Developmental and Epileptic Encephalopathy caused by biallelic loss-of-function mutations in the Ferric Chelate Reductase 1 Like (F...
Efficacy and safety of dual antiplatelet treatment up to 72 hours after mild ischemic stroke or transient ischemic attack in patients with established cardiovascular disease [0.03%]
对于已确诊心血管疾病的患者，在轻微缺血性卒中或短暂性脑缺血发作后最长72小时内双重抗血小板治疗的有效性和安全性研究
Zhang Xia,Ying Gao,Weiqi Chen et al.
Zhang Xia et al.
Patients with established cardiovascular disease (CVD) may have a higher risk of recurrent stroke and a higher prevalence of antiplatelet resistance than those without CVD. This study investigated the efficacy and safety of dual antiplatele...
Zinc as a phase-specific therapeutic target in hypoglycemia-induced brain injury [0.03%]
锌可作为低血糖性脑损伤的阶段特异性治疗靶点
Dong Gyun Ko,Hyun Wook Yang,Hyun Ho Jeong et al.
Dong Gyun Ko et al.
Hypoglycemia remains a major cause of neurological morbidity. However, effective targeted therapies for affected brain regions remain lacking. Although excitotoxicity and energy failure have long been implicated, emerging evidence has ident...
PrPC modulates BACE1-dependent amyloid pathology under chronic cerebral hypoperfusion: Implications for vascular cognitive impairment [0.03%]
慢性脑低灌注下PrPC调节BACE1依赖性的淀粉样病理改变及其在血管性认知障碍中的意义
Qingqing Sun,Xiang Yin,Yue Lang et al.
Qingqing Sun et al.
Vascular cognitive impairment (VCI) currently lacks effective pharmacological interventions, underscoring the need to identify novel therapeutic targets. Increasing evidence suggests that amyloid-β (Aβ) contributes to VCI pathogenesis by ...
Jan Kueckelhaus,Sebastian Jeising,Jacob S Young et al.
Jan Kueckelhaus et al.
Diffuse gliomas are the most common primary brain tumors in adults. Maximal safe resection represents the recommended initial management step for affected patients, and accumulating evidence emphasizes the favorable effects of more extensiv...