Butyrate modifies epigenetic and immune pathways in peripheral mononuclear cells from children with neurodevelopmental disorders associated with chromatin dysregulation [0.03%]
丁酸盐可修饰与染色质调节相关的神经发育障碍儿童外周单核细胞中的表观遗传和免疫途径
Jessica P Hayes,Velda X Han,Brooke A Keating et al.
Jessica P Hayes et al.
Pathogenic DNA variants in chromatin-related genes constitute an important minority of neurodevelopmental disorders (NDDs). Epigenetic mechanisms, including chromatin regulation driven by genetic or environmental factors, are increasingly r...
Deep brain stimulation of the medial geniculate body for refractory tinnitus: A feasibility study [0.03%]
内侧膝状体难治性耳鸣的深部脑刺激治疗：一项可行性研究
Shabnam Babakry,Jana V P Devos,Catharine A Hellingman et al.
Shabnam Babakry et al.
Tinnitus disorder can have a significant negative impact on quality of life, especially when refractory to standard care. Deep brain stimulation (DBS) of the medial geniculate body (MGB) attenuates pathological neuronal activity in the cent...
Lifespan dynamics of STN-based functional connectivity and network properties: Implications for motor dysfunction and circuit-based neuromodulation [0.03%]
基于STN的功能连接和网络属性的生命周期动力学及其对运动功能障碍和环路调节的启示
Yu-Lin Li,Jia-Jia Wu,Xi Zhang et al.
Yu-Lin Li et al.
Functional connectivity (FC) is crucial for the execution of functional activities and the progression of diseases. From a functional perspective, changes in subthalamic nucleus (STN)-based FC and network properties across lifespan and thei...
Validation in Drosophila of the in silico predicted clomipramine as repurposable for SOD1-ALS [0.03%]
基于计算预测的氯米帕明在模式生物果蝇中验证对SOD1-ALS再利用价值的研究
Francesco Liguori,Susanna Amadio,Chiara Angioli et al.
Francesco Liguori et al.
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive motor neuron degeneration and muscle weakness, generally leading to death due to respiratory failure within 2-5 years of symptom ons...
Metabolomics of cerebrospinal fluid following traumatic brain injury: Exploration of biomarkers for secondary injuries and severity [0.03%]
创伤性脑损伤后的脑脊液代谢组学：探索二次损伤和严重程度的生物标志物
Shuai Zhang,Zhuohang Wang,Jiangxin Mao et al.
Shuai Zhang et al.
Traumatic brain injury (TBI) constitutes a major global public health concern associated with substantial mortality and long-term disability, while its diagnostic approaches and underlying pathophysiological mechanisms remain to be fully el...
Interactions between cannabis use and chronic pain on sleep architecture: Findings from in-home EEG recordings [0.03%]
慢性疼痛与大麻使用对睡眠结构交互影响的在家EEG图谱研究
Tracy W Brown,Francesca M Filbey
Tracy W Brown
Pain and sleep disturbances are primary reasons for medicinal cannabis use. Cannabis influences both pain and sleep through its modulation of the endocannabinoid system, which regulates pain and sleep signaling. Despite their interconnected...
Intranasal (R)-ketamine modulates depression symptom and neurotransmitters-associated human brain connectivity [0.03%]
鼻内给药(R)型氯胺酮调节与抑郁症相关的神经递质的人脑连接性
Zhenxiang Zang,An&#x;ning Li,Zhifang Zhang et al.
Zhenxiang Zang et al.
Racemic (R,S)-ketamine exerts rapid antidepressant effects, and growing evidence suggests its R-isomer may offer sustained efficacy with fewer side effects. However, the neurobiological mechanisms underlying (R)-ketamine's action in the hum...
Ascorbic acid enhances antidepressant-like efficacy of esketamine: Hippocampal TARP-γ8-containing AMPA receptors mediate synaptic modulation [0.03%]
抗坏血酸增强左酮色林的抗抑郁样功效：海马TARP-γ8含肾上腺髓质素受体介导突触调制
Zhaojuan Ke,Ying Zhang,Xin Jiang et al.
Zhaojuan Ke et al.
Ketamine exhibits superior efficacy compared to conventional antidepressants, yet its clinical application remains limited by dose-dependent side effects. Ascorbic acid (AA) augments ketamine's antidepressant-like effects, suggesting that A...
Neuropsychiatric symptoms in Alzheimer's disease: Bridging mechanisms, management, and emerging innovations [0.03%]
阿尔茨海默病的精神行为症状：连接机制、管理和新兴创新
Deborah K Rose,Constantine G Lyketsos,Paul B Rosenberg et al.
Deborah K Rose et al.
Neuropsychiatric symptoms (NPS) are among the most distressing and functionally disruptive features of Alzheimer's disease (AD), affecting the vast majority of individuals across the disease continuum. These symptoms, ranging from apathy an...
Piperine alleviates retinal ischemic injury by mediating the APE1 signaling [0.03%]
胡椒碱通过调节APE1信号通路缓解视网膜缺血损伤
Qianxiong He,Yannan Chen,Peiwen Chen et al.
Qianxiong He et al.
Ischemic retinal damage is the most common cause of severe vision impairment and blindness. Anti-vascular endothelial growth factor (anti-VEGF) agents have transformed the treatment of retinal ischemic disorders and have become the cornerst...