Drug repurposing opportunities across 92 CNS-related conditions using deep learning and whole-genome sequencing [0.03%]
基于深度学习和全基因组测序的92种神经系统相关疾病药物再利用机会
Yichuan Liu,Hui-Qi Qu,Frank D Mentch et al.
Yichuan Liu et al.
CNS-related conditions span tumors, vascular, neurodevelopmental, and psychiatric disorders, yet therapeutic development for CNS disorders continues to face persistent delays and high attrition due to blood-brain barrier constraints, biolog...
Discovery of a CI-994 derivative as a dual modulator of class I histone deacetylases and Wnt/β-catenin signaling for Alzheimer's disease therapy [0.03%]
发现CI-994衍生物作为组蛋白去乙酰酶和Wnt/β-catenin信号传导的双重调节剂用于阿尔茨海默氏病治疗的研究
Wenyan Lu,Thomas R Caulfield,Eunmi Lee et al.
Wenyan Lu et al.
Alzheimer's disease (AD) is a multifactorial disease with mixed pathologies. Consequentially, drugs targeting multiple pathological processes may offer synergistic benefits. While histone deacetylase (HDAC) inhibitors have demonstrated effi...
Huoling Shengji granule in amyotrophic lateral sclerosis: A multicenter, randomized, double-blind, riluzole-controlled trial [0.03%]
复方生津颗粒治疗肌萎缩侧索硬化症的多中心随机双盲对照研究
Xiaolu Liu,Wencheng Fu,Xuanye Cui et al.
Xiaolu Liu et al.
Currently, no curative therapies exist for Amyotrophic Lateral Sclerosis (ALS). This study aimed to evaluate the efficacy and safety of Huoling Shengji granules (HLSJ), a traditional Chinese medicine (TCM), compared to the standard treatmen...
Site-targeted proximal complement C3 inhibition, but not C5 blockade, attenuates neurodegeneration in a mouse model of amyotrophic lateral sclerosis: Implications for failed clinical trials [0.03%]
在阿尔茨海默病小鼠模型中，针对部位的邻近补体C3抑制而非C5阻断可减轻神经退行性病变：失败的临床试验的启示
Moumita Majumder,Davis M Borucki,Nityananda Chowdhury et al.
Moumita Majumder et al.
Complement activation contributes to amyotrophic lateral sclerosis (ALS) neuropathology, but whether motor neuron degeneration is driven by proximal or terminal activation products remains unresolved. Failed trials of C5 inhibition - ravuli...
Identifying treatment-responsive patient subgroups in a neutral clinical trial of Intensive blood pressure reduction in acute intracerebral hemorrhage: A post hoc explainable machine learning analysis [0.03%]
基于机器学习分析，识别出急性脑出血期强化降压治疗有效的患者亚组：事后分析
Anh T Tran,Adnan I Qureshi,Junhao Wen et al.
Anh T Tran et al.
The Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH-2) trial reported no overall benefit from intensive blood pressure (BP) reduction in intracerebral hemorrhage (ICH), potentially masking benefit in select patient subgroups....
Disease-modifying effects on chronic axon damage and white matter degeneration with 4-aminopyridine after acute traumatic brain injury [0.03%]
急性脑损伤后用4-氨基吡啶治疗慢性轴索损伤和白质退变的疾病修正作用
Kryslaine L Radomski,Xiaomei Zi,Genevieve M Sullivan et al.
Kryslaine L Radomski et al.
Axonal injury is a hallmark pathology of acute traumatic brain injury (TBI) that drives degeneration of white matter in chronic TBI and in neurodegenerative diseases. No available therapies effectively treat damaged axons. We focused on ear...
The real-world safety profile of amitriptyline: A comprehensive pharmacovigilance analysis based on the large-scale FDA adverse event reporting system database [0.03%]
基于大规模FDA不良事件报告系统数据库的阿米特利普托啉药物警戒分析及现实世界中的安全特征研究
Ying Yang,Yanhua Xie,Liangjuan Hou et al.
Ying Yang et al.
Despite its established efficacy, the long-term safety profile of amitriptyline among broad patient populations remains insufficiently characterized. We thoroughly characterized the real-world safety profile of amitriptyline through a syste...
Deep brain stimulation in pediatric drug-resistant epilepsy: Implications for the developing connectome [0.03%]
儿童难治性癫痫的深部脑刺激对发育连接组的影响
Karim Mithani,Thiemo F Dinger,Carolina Gorodetsky et al.
Karim Mithani et al.
Epilepsy is increasingly recognized as a disorder of brain networks, and intracranial neuromodulation has emerged as a therapeutic strategy for individuals with drug-resistant epilepsy (DRE). In pediatric populations, however, ongoing brain...
α6GABAA receptor-selective positive allosteric modulator as a novel therapy for fibromyalgia: A proof-of-concept study in mice modeling chronic widespread musculoskeletal pain [0.03%]
选择性α6GABAA受体阳性变构调节剂作为纤维肌痛的新疗法：慢性广泛性肌肉骨骼疼痛小鼠模型的概念验证研究
Myles Sant-Cassia,Cheng-Han Lee,V V N Phani Babu Tiruveedhula et al.
Myles Sant-Cassia et al.
Fibromyalgia, a chronic pain disorder mainly due to central sensitization, remains an unmet medical need, as available treatments provide limited efficacy and are frequently associated with dose-limiting adverse effects. We previously devel...
Personalizing neuromodulation for chronic pain: A connectivity-guided trial [0.03%]
基于连接性的慢性疼痛神经调控个性化治疗试验
Enrico De Martino,Margit Midtgaard Bach,Bruno Nascimento Couto et al.
Enrico De Martino et al.
In this randomized, double-blind, controlled trial, we evaluated 8 weeks of repetitive transcranial magnetic stimulation (rTMS) for chronic pain, comparing classic primary motor cortex (M1) stimulation with a novel target-selection strategy...