Persistent histone H3K27 acetylation contributes to excessive scar formation after spinal cord injury through the regulation of microglial cholesterol accumulation [0.03%]
脊髓损伤后组蛋白H3K27乙酰化持续存在通过调节小胶质细胞胆固醇积累促进过度疤痕形成
Qiujiang Qiao,Qing Gong,Ning Li et al.
Qiujiang Qiao et al.
Scar formation is a critical determinant of neurological recovery following spinal cord injury (SCI) because scars act as a physical support and barrier that influences axonal regeneration and remyelination. However, the regulatory mechanis...
Diabetes mellitus and efficacy of dual antiplatelet in acute ischemic stroke: A post hoc analysis of the ATAMIS trial [0.03%]
糖尿病对急性缺血性卒中双重抗血小板治疗疗效的影响——ATAMIS试验的事后分析
Xiao-Wen Hou,Yu Cui,Hong-Ting Yan et al.
Xiao-Wen Hou et al.
We conducted a post hoc analysis of the ATAMIS (Antiplatelet Therapy in Acute Mild to Moderate Ischemic Stroke) trial to evaluate whether diabetes mellitus (DM) status affects the efficacy of antiplatelet therapy in acute mild-to-moderate i...
Lafora disease gene therapy: EPM2A but not EPM2B overexpression results in Lafora body formation [0.03%]
EPM2A基因而非EPM2B过表达导致拉福尔体形成
Esther O Alao,Mehrnaz Sheibani,Jun Wu et al.
Esther O Alao et al.
Lafora disease (LD) is a fatal teenage-onset neurodegenerative epilepsy caused by loss-of-function mutations of the genes encoding the laforin phosphatase-malin E3 ubiquitin ligase complex. This complex regulates glycogen structural integri...
Test-retest reliability and symptom association of personalized depression TMS targets: A comparative study of refined seed-based (RSA) and hierarchical clustering (HCA) approaches [0.03%]
个性化抑郁症TMS靶点的测试重测信度及与症状关联：精简种子-Based（RSA）和分层聚类（HCA）方法的比较研究
Hui Zhou,Yanmeng Bao,Jiasheng Xu et al.
Hui Zhou et al.
Personalized transcranial magnetic stimulation (TMS) targeting holds promise for improving depression treatment, but its clinical translation is hindered by limited open-source implementation and systematic comparisons of target reproducibi...
Cholecalciferol (vitamin D3) is an agonist of the Alzheimer's disease-associated immune receptor TREM2 [0.03%]
胆钙化醇（维生素D3）是与阿尔茨海默病相关的免疫受体TREM2的激动剂
Hunter B Dean,Ryan A Tuckey,Rory A Greer et al.
Hunter B Dean et al.
Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is one of the strongest genetic risk factors for late-onset Alzheimer's disease (AD). Several TREM2 ligands are known, including charged lipids and AD-associated proteins like apolipo...
Altered Erythrocyte Function via TLR9-ox-mtDNA Binding Links Mitochondrial Oxidative Damage to Systemic Inflammation in Multiple Sclerosis [0.03%]
TLR9-氧化型线粒体DNA结合通过改变红细胞功能将多发性硬化中的线粒体氧化损伤与全身炎症联系起来
Lingfei Yang,Qianmeng Hao,Yufei Chen et al.
Lingfei Yang et al.
Multiple sclerosis (MS), an autoimmune disorder of the central nervous system(CNS), is charactered by neuroinflammation and neurodegeneration. Red blood cells (RBCs) are the most abundant cells in circulation, yet their immunological roles ...
Neuronal alkaline phosphatase promotes the spread of Tau-induced pathology, and its blockade prevents neurodegeneration and memory loss [0.03%]
神经碱性磷酸酶促进Tau诱导的病理扩散，其阻断可防止神经退行性和记忆丧失
Lucía Soria-Tobar,Daniel Ouro-Corredera,Laura Roman-Valero et al.
Lucía Soria-Tobar et al.
Tauopathies, such as Alzheimer's disease (AD), are neurodegenerative disorders marked by abnormal intraneuronal aggregates of phosphorylated Tau protein. Unfortunately, no effective treatment is currently available. Since extracellular Tau ...
The real-world effectiveness and safety of off-label rituximab in a large cohort of Middle Eastern multiple sclerosis patients [0.03%]
利妥昔单抗在中东地区一大型多发性硬化症患者队列中的真实世界有效性和安全性
Ghida Ismail,Maya Zeineddine,Raed Al-Roughani et al.
Ghida Ismail et al.
Rituximab (RTX) is increasingly used off-label for the treatment of multiple sclerosis (MS), yet real-world evidence from Middle Eastern populations remains limited. This multicenter, retrospective observational study evaluated the effectiv...
Functional network reorganization following VIM-MRgFUS for essential tremor [0.03%]
VIM-MRgFUS治疗原发性震颤的功能网络重塑研究
Jinlong Liu,Jonas Krauss,Veronika Purrer et al.
Jinlong Liu et al.
Magnetic resonance-guided focused ultrasound (MRgFUS) is a promising, noninvasive therapeutic approach for essential tremor (ET), yet the effects of the respective lesions on functional brain network organization remain poorly understood. H...
Lithium chloride suppresses ferroptosis of induced pluripotent stem cells with ApoE4/E4 from a sporadic Alzheimer's disease patient [0.03%]
来自散发性阿尔茨海默病患者的ApoE4/E4诱导多能干细胞的铁死亡被氯化锂抑制
Ying Wang,Samuel Anchipolovsky,Piplu Bhuiyan et al.
Ying Wang et al.
Alzheimer's disease (AD), particularly its sporadic form (SAD, 95 % AD patients), is strongly associated with the apolipoprotein E4 (ApoE4) genotype and characterized by oxidative stress, iron dysregulation, and increased susceptibility to ...