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Cholecalciferol (vitamin D3) is an agonist of the Alzheimer's disease-associated immune receptor TREM2

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Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is one of the strongest genetic risk factors for late-onset Alzheimer's disease (AD). Several TREM2 ligands are known, including charged lipids and AD-associated proteins like apolipoprotein E and amylo... ...