Tumor microenvironment-modulated nanoparticles with cascade energy transfer as internal light sources for photodynamic therapy of deep-seated tumors [0.03%]
用于深部肿瘤光动力治疗的级联能量转移型肿瘤微环境响应式纳米内源光源疗法
Wenbin Dai,Xianchi Zhou,Jinchao Zhao et al.
Wenbin Dai et al.
Photodynamic therapy (PDT) is an appealing modality for cancer treatments. However, the limited tissue penetration depth of external-excitation light makes PDT impossible in treating deep-seated tumors. Meanwhile, tumor hypoxia and intracel...
Single-dose of integrated bilayer microneedles for enhanced hypertrophic scar therapy with rapid anti-inflammatory and sustained inhibition of myofibroblasts [0.03%]
一种单剂量的双层微针贴片治疗增生性疤痕的快速抗炎和持续抑制肌成纤维细胞作用方案
Yihua Xu,Qiong Bian,Yunting Zhang et al.
Yihua Xu et al.
Hypertrophic scar (HS) tends to raised above skin level with high inflammatory microenvironment and excessive proliferation of myofibroblasts. The HS therapy remains challenging due to dense scar tissue which makes it hard to penetrate, and...
Red light-induced localized release of carbon monoxide for alleviating postoperative cognitive dysfunction [0.03%]
红光诱导的局部一氧化碳释放用于缓解术后认知功能障碍
Mingde Li,Jian Cheng,Ruilin He et al.
Mingde Li et al.
Inflammation within the central nervous system (CNS), which may be triggered by surgical trauma, has been implicated as a significant factor contributing to postoperative cognitive dysfunction (POCD). The relationship between mitigating inf...
Enhanced anticancer efficacy of TRAIL-conjugated and odanacatib-loaded PLGA nanoparticles in TRAIL resistant cancer [0.03%]
TRAIL抗性的癌症中TRAIL偶联和Odanacatib负载的PLGA纳米粒子的增强抗癌功效
Thoa Thi Kim Nguyen,Seon Min Woo,Seung Un Seo et al.
Thoa Thi Kim Nguyen et al.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) demonstrates unique characteristics in anticancer therapies as it selectively induces apoptosis in cancer cells. However, most cancer cells are TRAIL-resistant. Odanacatib (ODN...
Photothermal switch by gallic acid-calcium grafts synthesized by coordination chemistry for sequential treatment of bone tumor and regeneration [0.03%]
棓酸钙配位合成型光热开关材料用于骨肿瘤序贯治疗与再生修复
Xiaodong Hou,Lei Zhang,Yixing Chen et al.
Xiaodong Hou et al.
The residual bone tumor and defects which is caused by surgical therapy of bone tumor is a major and important problem in clinicals. And the sequential treatment for irradiating residual tumor and repairing bone defects has wildly prospects...
Pulmonary delivery of silver nanoparticles prevents influenza infection by recruiting and activating lymphoid cells [0.03%]
银纳米颗粒的肺递送通过募集和激活淋巴细胞来预防流感感染
Lydie Martín-Faivre,Lisa Prince,Clémentine Cornu et al.
Lydie Martín-Faivre et al.
Silver nanoparticles (AgNPs) are a potential antiviral agent due to their ability to disrupt the viral particle or alter the virus metabolism inside the host cell. In vitro, AgNPs exhibit antiviral activity against the most common human res...
Local delivery of carboplatin-loaded hydrogel and calcium carbonate enables two-stage drug release for limited-dose radiation to eliminate mouse malignant glioma [0.03%]
载卡铂水凝胶和碳酸钙的局部给药能使小鼠恶性胶质瘤在有限剂量放疗下实现分阶段药物释放得以消除
Cheng-Yi Hsu,Jason Lin,Ming-Feng Wei et al.
Cheng-Yi Hsu et al.
Postoperative radiotherapy remains the gold standard for malignant glioma treatment. Clinical limitations, including tumor growth between surgery and radiotherapy and the emergence of radioresistance, reduce treatment effectiveness and resu...
Manganese-coordinated nanoparticle with high drug-loading capacity and synergistic photo-/immuno-therapy for cancer treatments [0.03%]
一种用于癌症治疗的高载药能力及光免疫协同治疗效应的锰配位纳米粒子
Han Chen,Haijing Qu,Yuqing Pan et al.
Han Chen et al.
Stimulator of interferon genes (STING) agonists have shown promise in cancer treatment by stimulating the innate immune response, yet their clinical potential has been limited by inefficient cytosolic entry and unsatisfactory pharmacologica...
Photoswitchable dynamics and RNAi synergist with tailored interface and controlled release reprogramming tumor immunosuppressive niche [0.03%]
可光切换的RNAi协同剂及其动力学再编程肿瘤免疫抑制微环境研究
Hongjie Xiong,Zhongquan Song,Tingya Wang et al.
Hongjie Xiong et al.
Immunosuppressive tumor microenvironment (ITM) severely limited the efficacy of immunotherapy against triple-negative breast cancer (TNBC). Herein, Apt-LPR, a light-activatable photodynamic therapy (PDT)/RNAi immune synergy-enhancer was con...
Semiconducting polymer nanoprodrugs enable tumor-specific therapy via sono-activatable ferroptosis [0.03%]
声激活铁死亡引发的聚合物纳米前药实现肿瘤特异性治疗
Fengshuo Wang,Zhiting Wu,Yijing Zhang et al.
Fengshuo Wang et al.
Ferroptosis, a recently identified form of cell death, holds promise for cancer therapy, but concerns persist regarding its uncontrolled actions and potential side effects. Here, we present a semiconducting polymer nanoprodrug (SPNpro) feat...