Magnetically controlled microgelbots with stem cells for the treatment of interstitial cystitis [0.03%]
用于治疗间质性膀胱炎的磁性可控干细胞微凝胶机器人
Hyunsik Choi,Bolam Kim,Yewon Seo et al.
Hyunsik Choi et al.
Stem cell therapy has been widely investigated for the treatment of chronic bladder diseases such as interstitial cystitis/bladder pain syndrome (IC/BPS). However, the delivery of stem cells into the bladder wall is limited due to the mucus...
Recent advances in exosome-based nanodelivery systems for Parkinson's disease [0.03%]
基于外泌体的纳米递送系统在帕金森病治疗中的最新进展
Yongqiang Zhu,Qi Xi,Yan Liu et al.
Yongqiang Zhu et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects dopaminergic neurons in the substantia nigra. Its multifactorial pathogenic mechanisms include oxidative stress, mitochondrial dysfunction, α-synuc...
A leucine derivate-adjuvanted LNP vaccine enhances antitumor immunity through mTOR activation and metabolic reprograming in dendritic cells [0.03%]
亮氨衍生物佐剂的LNP疫苗通过mTOR激活和树突状细胞中的代谢重编程增强抗肿瘤免疫反应
You Zhou,Yongyi Xie,Jialong Qi et al.
You Zhou et al.
Neoantigen-derived peptide vaccines have been emergingly employed to treat tumors, however, their inefficient delivery and antigenicity remain challenging. In this study, for the first time a leucine derivate LLOMe (L-leucyl-l-leucine methy...
Injectable natural Tremella-derived hydrogel for reversing ferroptosis-mediated osteoporotic microenvironment imbalance and promoting osteoregeneration [0.03%]
银耳多糖衍生的可注射天然生物材料水凝胶逆转铁死亡介导的骨微环境失衡促进骨再生修复
Cong Ye,Jiabao Xu,Lei Shi et al.
Cong Ye et al.
Osteoporotic bone defects constitute a global health predicament due to their restricted self-repairing capacity. Ferroptosis arising from iron overload represents a crucial pathological characteristic of osteoporosis, depleting osteoblasts...
Multifunctional monolithic gold nanowires for wireless smart wearable personalized healthcare device [0.03%]
多功能单晶金纳米线用于无线智能穿戴式个性化医疗设备
Sang Hoon Hong,Tae Yeon Kim,SangBaie Shin et al.
Sang Hoon Hong et al.
Despite extensive investigation on soft bioelectronic systems for smart healthcare, it remains a big technical challenge to achieve robust, wireless integration of multifunctional components via monolithic patterning. Here, we developed a w...
Disrupting tumor homeostasis with an autoamplificatory nanoinducer to augment pyroptosis for efficient immunotherapy [0.03%]
一种用于增强细胞焦亡实现高效免疫治疗的“自放大发炎症纳米诱导剂”扰乱肿瘤稳态的研究
Qiaoling Zhang,Ling Lin,Gui Chen et al.
Qiaoling Zhang et al.
Abnormal tumor homeostasis is crucial in maintaining tumor cell survival and growth. Thus, developing effective antitumor strategies that can simultaneously disrupt multiple intracellular homeostatic mechanisms may be more effective and les...
Generation of patient-derived sarcoma organoids for personalized drug screening and precision cancer immunotherapy [0.03%]
用于个性化药物筛选和精确癌症免疫治疗的患者衍生肉瘤器官样培养物的生成
Haixia Ma,Xiaoyang Li,Jinxi Li et al.
Haixia Ma et al.
Sarcomas are malignant tumors that display inter- and intra-tumoral heterogeneity. Patient-derived organoids enable the creation of systems that stably recapitulate many aspects of parental tumors in vitro. Thus, the idea of using patient-d...
"Sandwich" structured nanorods for timely antibiosis, immunoregulation and neuroangiogenesis to accelerate osteogenesis of Zn-based implants in diabetics [0.03%]
“夹心”结构纳米棒促进糖尿病骨缺损修复中锌植入物的及时抗菌、免疫调节和神经血管生成以加速成骨过程
Yang Xue,Lan Zhang,Mengting Mao et al.
Yang Xue et al.
Pathological microenvironment of diabetes predisposes to induce bacterial infection, sustained inflammatory response, and impaired neuroangiogenesis, impeding fracture repair. Zn-based implants have great potential to replace conventional T...
Biodegradable polymers with tertiary amines enhance mRNA delivery of lipid nanoparticles via improved endosomal escape [0.03%]
含三甲胺的可降解聚合物通过改善脂质纳米粒的溶酶体逃逸来增强其mRNA递送性能
Feng Zhao,Bruno Luppi,Po-Han Chao et al.
Feng Zhao et al.
Messenger RNA (mRNA)-based therapy has become a promising and scalable approach for treating various diseases, and lipid nanoparticles (LNPs) have recently gained prominence as a safe and effective delivery vehicle. LNPs not only protect mR...
Gold-embedded yolk-shell mesoporous organosilica nanocomposite for microwave-enhanced targeted chemotherapy and immune modulation in hepatocellular carcinoma [0.03%]
负载金壳核介孔有机硅纳米复合材料用于微波增强的肝癌靶向化疗和免疫调控
Wei Tian,Hanyao Sun,Ziqing Xu et al.
Wei Tian et al.
Microwave ablation (MWA), an innovative therapy for hepatocellular carcinoma (HCC), faces challenges of limited thermal effects and a tumor immunosuppressive microenvironment. Addressing these, we developed an advanced Au@PMO@DOX-Lac nanoco...