Incorporation of low-oxidation graphene oxide into electrospun poly(ε-caprolactone) /gelatin scaffolds for human embryonic stem cell-derived retinal pigment epithelium cell transplantation [0.03%]
低氧化石墨烯纳米片增强的聚己内酯/明胶支架促进人胚胎干细胞源性视网膜色素上皮细胞移植
Wei Wu,Yujia Cao,Qiyou Li et al.
Wei Wu et al.
Scaffold-based retinal pigment epithelium (RPE) transplantation is a candidate approach to preserve or recover vision for macular degeneration. Electrospun poly(ε-caprolactone) (PCL)/Gelatin (Gel) scaffolds have demonstrated support for ce...
Biomimetic nanosystem rewires microRNA-mediated inflammatory circuits and disrupts ROS crosstalk for multifaceted rheumatoid arthritis therapy [0.03%]
仿生纳米系统重塑微小核糖核酸介导的炎症回路并打断活性氧交叉对话实现多面类风湿关节炎治疗
Youcong Gong,Zijia Zhou,Jinkun Huang et al.
Youcong Gong et al.
Rheumatoid arthritis (RA) persists due to the intractable pro-inflammatory M1 macrophage phenotype, sustained by dysregulated cytokine/reactive oxygen species (ROS) production, where conventional single-target therapies fail to achieve dura...
Dynamic stiffening to improve vasculogenesis of hiPSC-Derived endothelial progenitors [0.03%]
动态刚度促进hiPSC来源内皮前体细胞的血管生成能力
Brett Stern,Jiwan Han,Kathleen Halwachs et al.
Brett Stern et al.
Multiple groups have reported on the impact of hydrogel stiffness on vascular network formation in vitro, with overall findings indicating that hydrogels with lower stiffness better support vasculogenesis. However, most of this research uti...
Injectable hydrogel-mediated spermidine delivery triggers tumor pyroptosis via oxidative metabolism for enhanced cancer therapy [0.03%]
可通过氧化代谢触发肿瘤细胞焦亡的支链多胺精胺增强癌症治疗的可注射水凝胶递送系统
Zheng Deng,Xirui Wu,Tianhao Huang et al.
Zheng Deng et al.
Intracellular polyamine metabolic homeostasis is closely linked to therapeutic outcomes in cancer. However, their intrinsic antitumor mechanisms have not been fully clarified. Herein, we demonstrate that the catabolism of spermine (Spm) and...
A Mg-Al layered double hydroxide-based nanocomposite functionalized with PTHrP-2 and loaded with polyoxometalates for osteoarthritis therapy [0.03%]
一种用于治疗骨关节炎的基于Mg-Al层状双氢氧化物纳米复合材料并带有PTHrP-2和多金属氧酸盐功能化的材料
Luhao Li,Guang Shi,Chen Chai et al.
Luhao Li et al.
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by cartilage degeneration, inflammation, and oxidative stress. Existing monotherapies exhibit limited efficacy as they fail to comprehensively address the disease's c...
Oral renal-clearable gold supraclusters for near-infrared II urinary diagnosis of ulcerative colitis [0.03%]
口服肾清除型金超团簇用于溃疡性结肠炎近红外II尿检诊断
Bang Liu,Jinghang Li,Ming Li
Bang Liu
Fluorescence biosensing offers a promising transformative strategy for non-invasively diagnosing diseases, but its deployment for clinical urinalysis is largely hindered by the lack of fluorescent endogenous biomarkers, insufficient detecti...
In situ engineering of a self-healing drug-scaffold hydrogel to block platelet-driven postoperative metastasis [0.03%]
体内工程化制备自修复药物载体水凝胶阻止血小板介导的术后转移
MiriGuli Musa,Jianbin Shi,Yupeng Wang et al.
MiriGuli Musa et al.
Surgical resection inadvertently promotes metastasis via platelet activation and tumor cell-platelet aggregation. Conventional postoperative therapies fail to address this early pro-metastatic window and lack precise local modulation. Herei...
Zhongqing Sun,Jie Zhao,Jia Li et al.
Zhongqing Sun et al.
Ischemic stroke remains a leading cause of long-term disability worldwide, and existing therapies have a very limited capacity to repair lost neurons or restore brain function. This review examines how biomaterial-enhanced stem cell therapi...
Synergistic immunotherapy of NSCLC enabled by a biomimetic nanodelivery system for autophagy-mediated MDSC reprogramming and metabolic modulation [0.03%]
一种用于自噬介导的髓源性抑制细胞重编程和代谢调节的仿生纳米递送系统，可协同免疫治疗非小细胞肺癌
Ziqi Guo,Xianyan Liang,Haoran Ding et al.
Ziqi Guo et al.
The immunosuppressive tumor microenvironment (TME) in non-small cell lung cancer (NSCLC), particularly the dominance of myeloid-derived suppressor cells (MDSCs), remains a major barrier to effective immunotherapy. Here, we developed a bioen...
Ru/CoMn-LDH@CTP nanozymes with catalytic antioxidant activity alleviate myocardial glucolipotoxicity through inhibition of lipid peroxidation [0.03%]
具有抗氧化活性的Ru/CoMn-LDH@CTP纳米酶通过抑制脂质过氧化缓解心肌糖脂毒性
Susu Zhang,Wuming Hu,Tao Wang et al.
Susu Zhang et al.
Diabetic cardiomyopathy (DbCM), a severe complication of type 2 diabetes mellitus (T2DM), is driven by glucolipid metabolism dysregulation-induced oxidative stress and ferroptosis. Current clinical management, primarily relying on glucose-l...