Framework nucleic acid-based hydrogel for sequential immune regulation and endogenous TGF-β1 capture in wound healing [0.03%]
基于框架核酸的用于序贯免疫调节和内源TGF-β1捕获的水凝胶促进伤口愈合
Wumeng Yin,Yichen Yang,Ziqi Yue et al.
Wumeng Yin et al.
Wound healing is a highly coordinated process that requires timely resolution of inflammation in the early phase and localized activation of regenerative signals during tissue remodeling. Disruption of this sequential regulation often leads...
Biomaterial-based strategies for cell-free nucleic acids scavenging and macrophage modulation in oral diseases: Mechanisms and therapeutic potential [0.03%]
用于口腔疾病的细胞外核酸清除和巨噬细胞调控的生物材料策略：机制与治疗潜力
Jiali Chen,Xu Cheng,Shiming Zhang et al.
Jiali Chen et al.
Cell-free nucleic acids (cfNAs), including cfDNA and cfRNA, have emerged as potent drivers of inflammation and immune dysregulation in oral diseases by activating nucleic acid-sensing pathways and inducing macrophage polarization. These pro...
"Restauro" strategy: Siderophore-like antibiofilm coating combats prosthetic joint infection and preserves implants via bacterial ferroptosis-like death [0.03%]
“ рестауро” 策略：类似色氨酸的抗生物膜涂层通过细菌铁死亡-like 死亡来对抗关节假体感染并保留植入物
Wushi Cui,Jiaxuan Zou,Congsun Li et al.
Wushi Cui et al.
Prosthetic joint infection (PJI) treatment failure primarily stems from incomplete biofilm removal and antibiotic resistance. Addressing these challenges, antibiotic-independent antimicrobials become preferred weapons. Meanwhile, iron metab...
Nanomaterial-based strategies for anti-aging and regeneration in oral and maxillofacial tissues: Mechanisms and applications [0.03%]
纳米材料在口腔和颌面组织抗衰老及再生中的策略、机制及应用研究
Xin-Jia Cai,Ying-Ying Cui,Chuan-Yang Ding et al.
Xin-Jia Cai et al.
The escalating global aging population underscores the urgent need to elucidate senescence-mediated tissue degeneration and impaired repair mechanisms, particularly in oral and maxillofacial regions where compromised regenerative capacity s...
A bimetallic catalyst core-shell nanoplatform enabling all-stage management of infected diabetic wound healing [0.03%]
一种双金属催化剂核壳纳米平台可在糖尿病感染伤口愈合的全阶段进行管理
Huihui Xie,Lan Zhang,Tiexin Ding et al.
Huihui Xie et al.
The impaired healing of diabetic wounds is largely attributable to the pathological microenvironment, which promotes susceptibility to bacterial infection, hyperinflammation, vasculopathy, and neuropathy. To address these issues, a bimetall...
Lipid nanoparticles that co-deliver poly(I:C) and short peptide antigens elicit anti-tumor responses with vaccination [0.03%]
共递送聚(I:C)和短肽抗原的脂质纳米颗粒疫苗诱导抗肿瘤免疫响应
Yuan Luo,Qinzhe Li,Shiqi Zhou et al.
Yuan Luo et al.
Polyriboinosinic-polyribocytidylic acid (pIC) is a Toll-like receptor 3 (TLR3) agonist that has been used as a vaccine adjuvant. Here, we show that an integrated lipid nanoparticle (LNP) which co-delivers pIC together with short peptide imm...
Hydrogel-based piezoelectric materials and devices for implantable bioelectronics [0.03%]
用于植入式生物电子学的基于水凝胶的压电材料和设备
Saswat Choudhury,Zhong Lin Wang,Sang-Woo Kim
Saswat Choudhury
Next-generation biomedical devices increasingly require integrated energy harvesting and miniaturized electronic components to achieve self-sustaining operation without external power sources. However, most currently available systems remai...
An injectable ROS-responsive hydrogel comprising chondroitin sulfate@resveratrol liposome package for osteoarthritis alleviation [0.03%]
一种载有壳聚糖硫酸盐@白藜芦醇脂质体的ROS响应性可注射水凝胶用于治疗骨关节炎
Lamei Liu,Min Zhang,Yan Zhou et al.
Lamei Liu et al.
Osteoarthritis (OA) is a complex and multifactorial joint disorder. Currently, there are few therapies to slow the progression of OA. Combining symptomatic slow-acting drugs and reactive oxygen species (ROS) scavenging reagents in the infla...
Engineering biomimetic tissue barrier models on chips: From design and fabrication to applications in disease modeling and drug screening [0.03%]
芯片上工程仿生组织屏障模型：从设计和制造到疾病建模和药物筛选中的应用
Rohollah Nasiri,Masoud Madadelahi,Mohammad Reza Nikmaneshi et al.
Rohollah Nasiri et al.
Replicating the in vitro properties of tissue barriers-such as the blood-brain barrier, gut, skin, lung, kidney, retina, nasal epithelium, and placenta-is crucial for many applications, including drug screening, studying molecular transport...
Advanced biomaterials regulating mitochondria for treatment of peri-implantitis [0.03%]
用于治疗种植体周围炎的调控线粒体生物材料研究进展
Ning Gao,Bicong Gao,Junhong Lai et al.
Ning Gao et al.
Peri-implantitis is a pathogenic disease post-dental implantation, which is initiated by plaque accumulation and coupled with the dissemination of Ti or TiO2 particles. The inflammatory cascade in the proximity of the implant ultimately res...