Qiang Li,Yuan Meng
Qiang Li
Hearing deprivation induces structural and functional reorganization in the brain, which compromises an individual's language processing capacity. As a tonal language, Mandarin Chinese requires fine-grained auditory processing for lexical t...
Functional near-infrared spectroscopy (fNIRS) biomarkers of tinnitus severity within tinnitus subtypes [0.03%]
耳鸣亚型中功能近红外光谱(tINRS)生物标志物预测耳鸣严重程度的研究
Mehrnaz Shoushtarian,Jamal Esmaelpoor,Michelle M G Bravo et al.
Mehrnaz Shoushtarian et al.
Tinnitus, the perception of sounds not present externally, can significantly impair quality of life. Currently there are no clinically available objective measures to enable monitoring of tinnitus-related changes in brain activity. Our prev...
Beyond suppression: Self-generation enhances perceived loudness and cortical responses to faint sounds [0.03%]
超越抑制：自我生成增强对微弱声音的感知响度和皮层反应
Carla Salgado,Stefanie Sturm,Marc Via et al.
Carla Salgado et al.
Perceptual and neural attenuation for self-generated (SG) sounds at clearly audible intensities is well established, yet recent work suggests a reversal at near-threshold levels, with SG sounds perceived as louder. Here we tested whether th...
Mineralocorticoid and glucocorticoid receptors in the mammalian inner ear: a scoping review [0.03%]
哺乳动物内耳的矿皮质激素受体和糖皮质激素受体：系统综述
Ewa Domarecka,Evi De Backer,Elsa Edlund et al.
Ewa Domarecka et al.
Mineralocorticoid (MR) and glucocorticoid (GR) receptors regulate stress and inflammation pathways relevant to hearing and balance, as well as corticosteroid treatments. However, translation to clinical outcomes remains inconsistent, likely...
Morgan Thienpont,F Deloche,S Keshishzadeh et al.
Morgan Thienpont et al.
Animal experiments have provided many insights on auditory function, notably in cases of sensorineural hearing loss (SNHL). However, it is not always clear how these findings translate to the human auditory system, especially in clinically ...
Bioinformatics Re-analysis of murine transcriptomic datasets identifies SASP and MAPK/NF-κB signaling pathways in noise-accelerated cochlear aging [0.03%]
生物信息学再分析小鼠转录组数据集，确定噪声加速耳蜗衰老中的SASP和MAPK/NF-κB信号通路
Guoping Zhang,Dandan Ren,Suju Wang
Guoping Zhang
Noise exposure is an important contributor to age-related hearing loss (ARHL) or presbycusis; however, the underlying mechanism remains elusive. This study re-analyzed two Mus musculus cochlear transcriptomic datasets on acoustic trauma fro...
Speech-in-noise difficulties in aminoglycoside ototoxicity reflects combined afferent and efferent dysfunction [0.03%]
氨基糖苷类药物耳毒性的噪音环境下言语理解困难反映了传入和传出功能障碍的共同作用
Lina Motlagh-Zadeh,Diala Izhiman,Chelsea M Blankenship et al.
Lina Motlagh-Zadeh et al.
Objectives: Patients with Cystic fibrosis (CF) often receive aminoglycosides (AGs) to manage recurrent pulmonary infections, placing them at risk for ototoxicity. Chronic AG use can lead to complex cochlear damage affecti...
Temporal evolution of impedance after motorized versus manual cochlear implantation [0.03%]
电动力与手动式人工耳蜗植入术后的阻抗变化特点
Benjamin Bircher,Philipp Aebischer,Raphael Andonie et al.
Benjamin Bircher et al.
Background: Cochlear implant (CI) candidacy increasingly includes patients with residual hearing, making atraumatic electrode insertion essential. Motorized insertion tools (MITs) aim to standardize electrode insertion an...
Meng Deng,Zhengqing Hu
Meng Deng
Progranulin (encoded by Grn) is a multifunctional glycoprotein implicated in neuronal survival and synapse function, yet its role in central auditory circuit development remains unclear. In this study, we investigated the role of Grn in mou...
Effect of length variations in 3D-printed middle-ear prostheses on ossicular chain mobility [0.03%]
3D打印中耳假体长度变化对听小骨链活动度的影响
Jacek Sokołowski,Adam Orłowski,Kazimierz Niemczyk et al.
Jacek Sokołowski et al.
Background: Patient-specific 3D printing may improve ossiculoplasty, yet the mechanical tolerance to prosthesis length remains poorly quantified. We evaluated how systematic lengthening of a custom 3D-printed incus replac...