Bridging the gap: mechanisms and novel translational strategies to prevent cisplatin-induced ototoxicity [0.03%]
Jie Bai,Wenjia Wang,Zeming Fu et al.
Jie Bai et al.
Cisplatin is a widely used chemotherapeutic agent, but its clinical utility is limited by dose-dependent ototoxicity, causing irreversible sensorineural hearing loss and significantly impairing quality of life, especially in pediatric patie...
P Livens,S Van der Jeught,J J J Dirckx et al.
P Livens et al.
Optical coherence tomography (OCT) vibrometry is a promising tool for middle-ear mechanics, but single-frequency approaches limit efficiency and diagnostic power. We introduce multisine OCT vibrometry in a rabbit model to capture broadband,...
Age-related hearing loss involves mitochondrial DNA instability and copy number depletion in the cochlea: Insights from in vivo and in vitro models [0.03%]
Akil Turner,Bo Ding,Xiaoxia Zhu et al.
Akil Turner et al.
Age-related hearing loss (ARHL) is a highly prevalent sensory neurodegenerative disorder that involves various molecular mechanisms. The present study investigated if age-related oxidative stress (OS) induces alterations in mitochondrial DN...
William Keustermans,Peter Ter Heerdt,Joris Jj Dirckx et al.
William Keustermans et al.
We present an industrially manufacturable digital otoscope designed to measure the three-dimensional shape of the tympanic membrane while being compatible with standard examination procedures. The system employs optical profilometry and ove...
Jessica Ky-Lee Choong,Dongcheng Zhang,Amy Judith Hampson et al.
Jessica Ky-Lee Choong et al.
Introduction: The tissue response to cochlear implantation is thought to be involved in the loss of residual hearing, and its extent has been found to affect speech perception. This study investigated tissue response form...
Multi-feature machine learning classification of sonotubometry for eustachian tube dysfunction assessment [0.03%]
用于咽鼓管功能障碍评估的声导测试多特征机器学习分类
Linwei Zhang,Xikun Lu,Yangyang Zheng et al.
Linwei Zhang et al.
Eustachian tube dysfunction (ETD) is a critical factor for otitis media with effusion (OME) in children, yet there is currently no gold standard for its direct clinical measurement. Sonotubometry serves as a physiological diagnosis method f...
Towards precision medicine for otology and neurotology: Machine learning applications and challenges [0.03%]
耳科和神经耳科精确诊断的机器学习应用与挑战
Katherine Adcock,Elva Arulchelvan,Nathan Shields et al.
Katherine Adcock et al.
Advances in artificial intelligence, particularly machine learning and deep learning, in conjunction with the rise of personalised medicine, can facilitate tailored decision-making for diagnoses, prognoses, and treatment responses based on ...
Irina Wils,Tobias Mair,Ivo Dobrev et al.
Irina Wils et al.
Effective mechanical coupling between bone conduction implants and the skull is essential for optimal auditory stimulation. The Bonebridge™ (MED-EL, Innsbruck, Austria) uses cortical screws to secure the transducer to the mastoid bone. How...
Increased vulnerability to noise exposure of low spontaneous rate type 1C spiral ganglion neuron synapses with inner hair cells [0.03%]
低自发率I型螺旋神经元和内毛细胞突触对噪声暴露的敏感性增强
Daniel O J Reijntjes,Kali Burke,Srijita Paul et al.
Daniel O J Reijntjes et al.
The inner hair cells (IHCs) in the inner ear form synapses with auditory nerve fibers (ANFs) that send sound signals to the brain. ANFs have been grouped by their level of spontaneous firing rates (SRs) into high-, medium-, and low-SR ANFs....
Conceptualizing the substrates and sequelae of decreased sound tolerance as a developmental cascade: A pilot study [0.03%]
耳声耐受降低的后遗效应及发病机制的发育级联假说：一项概念性研究
Ava Schwartz,Grace Pulliam,Jacob I Feldman et al.
Ava Schwartz et al.
A growing body of research has shown that decreased sound tolerance (DST) is highly prevalent and impacts the mental health of affected individuals. Recent work has shown this is especially true for autistic individuals. The extant literatu...