Translational framework combining machine learning and in vivo screening for aminoglycoside ototoxicity prevention [0.03%]
结合机器学习和体内筛选的氨基糖苷耳毒性预防的转化框架
Eunjung Han,Yun Jae Choi,Hong Ki Kim et al.
Eunjung Han et al.
Aminoglycosides are potent antibiotics, but their clinical use is limited by ototoxicity. Traditional drug screening is labor-intensive and inefficient in identifying safer alternatives. To address this, we developed a rapid screening frame...
''Comparing the effectiveness of the combination of hyperbaric oxygen therapy and systemic glucocorticoids in the treatment of sensorineural hearing loss resulting from shooting noise versus blast injury'' [0.03%]
高压氧联合全身糖皮质激素治疗枪击噪声致耳聋与爆炸伤耳聋的疗效比较
Ivan Gur,Inbar Gur,Liel Mogilevski et al.
Ivan Gur et al.
Background: A paucity of evidence exists as to the comparison of neurotologic injuries caused by explosive blast compared to the much more common gunshot-noise induced acute acoustic trauma (AAT). We aimed to compare the ...
Integrative network toxicology and proteomics identifies key pathways in gentamicin-induced ototoxicity [0.03%]
整合网络毒理学和蛋白质组学鉴定出庆大霉素致耳毒性的关键通路
Runnan Han,Ning Yu,Lin Shi
Runnan Han
Gentamicin (GEN), a representative aminoglycoside antibiotic, plays an irreplaceable role in clinical anti-infective therapy. However, its ototoxicity is one of the major adverse effects that limit long-term or high-dose application. Ototox...
Decoding selective attention in cochlear implant users with ipsilateral residual hearing [0.03%]
单侧人工耳蜗植入伴残余听力患者的注意选择机制解析
Hanna Dolhopiatenko,Costanza Bruni,Waldo Nogueira
Hanna Dolhopiatenko
Background: Cochlear implant (CI) users with ipsilateral residual hearing receive electric and acoustic stimulation (EAS). The combination of both stimulation modalities results in significant benefits in terms of speech ...
Carlos Jurado,Markus Drexl
Carlos Jurado
Intense sound stimulation can transiently affect various read-outs of cochlear sensitivity after stimulus cessation, for which the term bounce-phenomenon (BP) has been coined. To better understand stimulus characteristics determining the na...
Katarina C Poole,Simon With,Vincent Martin et al.
Katarina C Poole et al.
Everyday listening relies on the auditory system's ability to automatically monitor background ("non-target") sounds that lie outside the focus of attention to detect new or changing sources. Although change detection is a fundamental aspec...
Multisession epidural direct current stimulation of the auditory cortex mitigates age-related transcriptomic dysregulation in Wistar rats [0.03%]
多阶段硬膜外直接电流刺激听觉皮层可减轻Wistar大鼠年龄相关的转录组失调现象
Inés S Fernández Del Campo,Alejandro Cebrián-León,Carlos Hernández-Del Caño et al.
Inés S Fernández Del Campo et al.
Age-related hearing loss (ARHL) disrupts ascending auditory inputs, impairing auditory signal transmission, triggering cortical hyperexcitability, and increasing the risk of age-related cognitive decline. In early aging, multisession epidur...
Recovery patterns and influencing factors of temporary threshold shifts in occupational noise-exposed workers [0.03%]
职业噪声暴露工人听力临时上升的恢复模式及影响因素分析
Jing Qian,Minghui Xiao,Jijun Guo et al.
Jing Qian et al.
Noise-induced hearing loss represents a significant global occupational health issue. Understanding the recovery patterns of temporary threshold shift (TTS) is crucial for early intervention. This longitudinal study enrolled 140 occupationa...
Cochlear neural degeneration is key to the variation in word scores among people with similar thresholds [0.03%]
cochlear神经退化是具有相似听阈的人在单词得分方面存在差异的关键因素
Charanjeet Kaur,Pei-Zhe Wu,Jennifer T O&#x;Malley et al.
Charanjeet Kaur et al.
Patients with Ménière's disease show lower word scores than those with other types of sensorineural hearing loss [Grant et al., 2022, Sci. Reports 12(1):8929]. We hypothesized that cochlear neural degeneration is a key driver of these dif...
Short-wave world revisited: Resonance in a two-dimensional cochlear model [0.03%]
短波世界回访：二维耳蜗模型中的共振现象
E De Boer
E De Boer
According to the type of wave motion occurring, the length of the cochlea can be divided into three parts: in the first part there is a travelling wave with location-dependent propagation velocity, in the second the motion is dominated by r...